OPRL1 and CERS6

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (affinity chromatography technology, two hybrid, affinity chromatography technology)

		OPRL1	CERS6
Description		opioid related nociceptin receptor 1	ceramide synthase 6
Image
GO Annotations	Cellular Component	Plasma Membrane Membrane Cytoplasmic Vesicle Neuron Projection Synaptic Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Nociceptin Receptor Activity G Protein-coupled Receptor Activity G Protein-coupled Opioid Receptor Activity Protein Binding G Protein-coupled Peptide Receptor Activity Neuropeptide Binding	DNA Binding Protein Binding Transferase Activity Sphingosine N-acyltransferase Activity
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Neuron-neuron Synaptic Transmission Sensory Perception Sensory Perception Of Pain Calcium-mediated Signaling G Protein-coupled Opioid Receptor Signaling Pathway	Lipid Metabolic Process Sphingolipid Metabolic Process Inflammatory Response Oligodendrocyte Development Sphingolipid Biosynthetic Process Ceramide Biosynthetic Process Positive Regulation Of Oligodendrocyte Apoptotic Process
Pathways		Peptide ligand-binding receptors G alpha (i) signalling events	Sphingolipid de novo biosynthesis
Drugs		Buprenorphine Etorphine Epicept NP-1
Diseases
GWAS		A body shape index ( 34021172) Cerebrospinal AB1-42 levels in normal cognition ( 29274321) HDL cholesterol levels ( 32203549) LDL peak particle diameter (total fat intake interaction) ( 26112879) Lymphocyte count ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (HMG CoA reductase inhibitors) ( 31015401) Metabolic syndrome ( 31589552) Triglyceride levels ( 32203549 32154731) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Bipolar disorder ( 31043756 34002096) Parkinson's disease ( 27182965) Recurrent major depressive disorder ( 34099189) Recurrent major depressive disorder x sex interaction ( 34099189) Red cell distribution width ( 27863252 28957414 32888494) Skin aging (microtopography measurement) ( 28502801) Thyroid stimulating hormone levels ( 32769997) Triglyceride levels ( 32203549)
Interacting Genes		10 interacting genes: CERS6 DNAJC30 GNA14 GPRASP1 HLA-C OPRM1 PLLP PNOC RGS19 SLC31A2	5 interacting genes: AGTR1 BCL2L13 CERS2 OPRL1 SEC22B
Entrez ID		4987	253782
HPRD ID		03971	17258
Ensembl ID		ENSG00000125510	ENSG00000172292
Uniprot IDs		A0A5F9ZI64 P41146 Q8IXB0	Q6ZMG9
PDB IDs		4EA3 5DHG 5DHH 8F7X	8QZ6 8QZ7 9EOT
Enriched GO Terms of Interacting Partners?		Regulation Of Copper Ion Transmembrane Transport TAP Binding Neuropeptide Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Regulation Of NMDA Receptor Activity Cellular Response To Morphine Morphine Receptor Activity Sensory Perception Of Pain Negative Regulation Of Wnt Protein Secretion Beta-endorphin Receptor Activity Opioid Receptor Binding Opioid Peptide Activity G Protein-coupled Receptor Catabolic Process Regulation Of Transcytosis Compact Myelin Regulation Of Mitochondrial ATP Synthesis Coupled Proton Transport Positive Regulation Of Oligodendrocyte Apoptotic Process Receptor Ligand Activity	Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Calcium-mediated Signaling Angiotensin Type I Receptor Activity Phospholipase C-activating Angiotensin-activated Signaling Pathway Bradykinin Receptor Binding Renin-angiotensin Regulation Of Aldosterone Production Nociceptin Receptor Activity Negative Regulation Of Schwann Cell Proliferation Involved In Axon Regeneration Negative Regulation Of Schwann Cell Migration Angiotensin Type II Receptor Activity Maintenance Of Blood Vessel Diameter Homeostasis By Renin-angiotensin G Protein-coupled Opioid Receptor Activity Negative Regulation Of Glial Cell Migration Sphingosine N-acyltransferase Activity Regulation Of Lipid Metabolic Process Positive Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Regulation Of Renal Sodium Excretion Neuron-neuron Synaptic Transmission G Protein-coupled Opioid Receptor Signaling Pathway Negative Regulation Of Autophagosome Assembly Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Negative Regulation Of Axon Regeneration Negative Regulation Of Schwann Cell Proliferation N-acyltransferase Activity Negative Regulation Of Neuron Projection Regeneration G Protein-coupled Receptor Activity Low-density Lipoprotein Particle Remodeling Positive Regulation Of Macrophage Derived Foam Cell Differentiation Angiotensin-activated Signaling Pathway Renal System Process Involved In Regulation Of Systemic Arterial Blood Pressure Glycolytic Process Through Glucose-6-phosphate Oxidative Phosphorylation Glycolytic Process Through Fructose-6-phosphate Canonical Glycolysis Negative Regulation Of Glial Cell Proliferation Regulation Of Glial Cell Migration
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