OPRL1 and GNA14

Number of citations of the paper that reports this interaction (PMID 9862775)
4

Data Source:
HPRD (in vivo, in vitro)

		OPRL1	GNA14
Gene Name		opiate receptor-like 1	guanine nucleotide binding protein (G protein), alpha 14
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Cytoplasmic Membrane-bounded Vesicle Neuron Projection	Heterotrimeric G-protein Complex Plasma Membrane Extracellular Vesicular Exosome
	Molecular Function	Nociceptin Receptor Activity G-protein Coupled Receptor Activity Protein Binding Neuropeptide Binding	G-protein Coupled Receptor Binding GTPase Activity Signal Transducer Activity GTP Binding G-protein Beta/gamma-subunit Complex Binding Metal Ion Binding
	Biological Process	Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Neuropeptide Signaling Pathway Synaptic Transmission Sensory Perception Behavior Sensory Perception Of Pain Opioid Receptor Signaling Pathway	Signal Transduction Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Blood Coagulation Platelet Activation Phospholipase C-activating Dopamine Receptor Signaling Pathway
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding	G alpha (q) signalling events Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Signaling by GPCR ADP signalling through P2Y purinoceptor 1 Integration of energy metabolism Regulation of insulin secretion Signal amplification Thrombin signalling through proteinase activated receptors (PARs) G alpha (q) signalling events GPCR downstream signaling Acetylcholine regulates insulin secretion Gastrin-CREB signalling pathway via PKC and MAPK Thromboxane signalling through TP receptor Platelet activation, signaling and aggregation Free fatty acids regulate insulin secretion
Drugs
Diseases
GWAS
Protein-Protein Interactions		4 interactors: GNA14 GPRASP1 PNOC RGS19	9 interactors: ADRB2 CCR1 CHRM2 CXCR1 CXCR2 DNAL4 JMJD6 OPRL1 SSTR2
Entrez ID		4987	9630
HPRD ID		03971	05095
Ensembl ID		ENSG00000125510	ENSG00000156049
Uniprot IDs		P41146	B1ALW3 O95837
PDB IDs		4EA3
Enriched GO Terms of Interacting Partners?		Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway G-protein Coupled Receptor Catabolic Process Regulation Of G-protein Coupled Receptor Protein Signaling Pathway G-protein Coupled Receptor Signaling Pathway Phospholipase C-activating Dopamine Receptor Signaling Pathway Receptor Catabolic Process	G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Cell Surface Receptor Signaling Pathway Dendritic Cell Chemotaxis G-protein Coupled Receptor Signaling Pathway Dendritic Cell Migration Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Interleukin-8-mediated Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Cytosolic Calcium Ion Homeostasis Chemokine-mediated Signaling Pathway Signal Transduction Signaling Homeostatic Process Cellular Calcium Ion Homeostasis Cell Communication Calcium Ion Homeostasis Leukocyte Chemotaxis Cellular Metal Ion Homeostasis Cellular Response To Stimulus Cellular Cation Homeostasis Response To External Stimulus Cellular Ion Homeostasis Metal Ion Homeostasis Cell Chemotaxis Cellular Chemical Homeostasis Ion Homeostasis Endocytosis Leukocyte Migration Response To Stimulus Cellular Homeostasis Vesicle-mediated Transport Receptor Internalization Chemical Homeostasis Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Cell-cell Signaling Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Receptor-mediated Endocytosis Positive Regulation Of Leukocyte Chemotaxis Cellular Response To Organic Substance Regulation Of Bone Mineralization Negative Regulation Of Neutrophil Apoptotic Process Histone H3-R2 Demethylation Histone H4-R3 Demethylation Peptidyl-lysine Hydroxylation To 5-hydroxy-L-lysine Receptor Metabolic Process Inflammatory Response Positive Regulation Of Leukocyte Migration Cytokine-mediated Signaling Pathway Neuropeptide Signaling Pathway Positive Regulation Of Chemotaxis
Tagcloud ?			adam19 adamts16 adamts9 aggf1 altitude altitudes ccbe1 creld1 dahe dhp dwells f2rl1 fgf10 fgf5 foxm gdap1 involvements jmjd1c nrbf2 parp8 pla2g4a rhog rtel1 sweeps vegfc vps13a wuzhishan wzsp zfpm2
Tagcloud (Difference) ?			adam19 adamts16 adamts9 aggf1 altitude altitudes ccbe1 creld1 dahe dhp dwells f2rl1 fgf10 fgf5 foxm gdap1 involvements jmjd1c nrbf2 parp8 pla2g4a rhog rtel1 sweeps vegfc vps13a wuzhishan wzsp zfpm2
Tagcloud (Intersection) ?