OPRL1

Name	opioid related nociceptin receptor 1
Structure
Interactors	10 interactors: CERS6 DNAJC30 GNA14 GPRASP1 HLA-C OPRM1 PLLP PNOC RGS19 SLC31A2
GO Annotations	Cellular Component	Plasma Membrane Membrane Cytoplasmic Vesicle Neuron Projection Synaptic Membrane
	Molecular Function	Nociceptin Receptor Activity G Protein-coupled Receptor Activity G Protein-coupled Opioid Receptor Activity Protein Binding G Protein-coupled Peptide Receptor Activity Neuropeptide Binding
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Neuron-neuron Synaptic Transmission Sensory Perception Sensory Perception Of Pain Calcium-mediated Signaling G Protein-coupled Opioid Receptor Signaling Pathway
Pathways	Peptide ligand-binding receptors G alpha (i) signalling events
Drugs	Buprenorphine Etorphine Epicept NP-1
GWAS	A body shape index ( 34021172 ) Cerebrospinal AB1-42 levels in normal cognition ( 29274321 ) HDL cholesterol levels ( 32203549 ) LDL peak particle diameter (total fat intake interaction) ( 26112879 ) Lymphocyte count ( 32888494 ) Mean corpuscular hemoglobin ( 32888494 ) Mean corpuscular volume ( 27863252 32888494 ) Mean reticulocyte volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Medication use (HMG CoA reductase inhibitors) ( 31015401 ) Metabolic syndrome ( 31589552 ) Triglyceride levels ( 32203549 32154731 ) Waist circumference adjusted for body mass index ( 34021172 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 )
Entrez ID	4987
HPRD ID	03971
Ensembl ID	ENSG00000125510
Uniprot IDs	A0A5F9ZI64 P41146 Q8IXB0
PDB IDs	4EA3 5DHG 5DHH 8F7X
GO Terms Enriched among Interactors ?	Regulation Of Copper Ion Transmembrane Transport TAP Binding Neuropeptide Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Regulation Of NMDA Receptor Activity Cellular Response To Morphine Morphine Receptor Activity Sensory Perception Of Pain Negative Regulation Of Wnt Protein Secretion Beta-endorphin Receptor Activity Opioid Receptor Binding Opioid Peptide Activity G Protein-coupled Receptor Catabolic Process Regulation Of Transcytosis Compact Myelin Regulation Of Mitochondrial ATP Synthesis Coupled Proton Transport Positive Regulation Of Oligodendrocyte Apoptotic Process Receptor Ligand Activity