OPRL1 and PNOC

Number of citations of the paper that reports this interaction (PMID 11097863)
8

Data Source:
BioGRID (pull down, pull down)
HPRD (in vivo, in vitro)

		OPRL1	PNOC
Gene Name		opiate receptor-like 1	prepronociceptin
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Cytoplasmic Membrane-bounded Vesicle Neuron Projection	Extracellular Region
	Molecular Function	Nociceptin Receptor Activity G-protein Coupled Receptor Activity Protein Binding Neuropeptide Binding	Opioid Peptide Activity Neuropeptide Hormone Activity Protein Binding
	Biological Process	Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Neuropeptide Signaling Pathway Synaptic Transmission Sensory Perception Behavior Sensory Perception Of Pain Opioid Receptor Signaling Pathway	Signal Transduction Neuropeptide Signaling Pathway Synaptic Transmission Sensory Perception
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs
Diseases
GWAS
Protein-Protein Interactions		4 interactors: GNA14 GPRASP1 PNOC RGS19	1 interactors: OPRL1
Entrez ID		4987	5368
HPRD ID		03971	03268
Ensembl ID		ENSG00000125510	ENSG00000168081
Uniprot IDs		P41146	Q13519
PDB IDs		4EA3
Enriched GO Terms of Interacting Partners?		Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway G-protein Coupled Receptor Catabolic Process Regulation Of G-protein Coupled Receptor Protein Signaling Pathway G-protein Coupled Receptor Signaling Pathway Phospholipase C-activating Dopamine Receptor Signaling Pathway Receptor Catabolic Process	Opioid Receptor Signaling Pathway Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Sensory Perception Of Pain Neuropeptide Signaling Pathway Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Positive Regulation Of Cytosolic Calcium Ion Concentration Cytosolic Calcium Ion Homeostasis Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Cellular Metal Ion Homeostasis Cellular Cation Homeostasis Cellular Ion Homeostasis Metal Ion Homeostasis Cellular Chemical Homeostasis Ion Homeostasis Synaptic Transmission Behavior
Tagcloud ?			1beta antagonized cultures curve cytokine cytokines extents feedback fq incubation inf lipopolysaccharide lps mediators modulation nociceptin nop normalized orphanin prepro quartile rd respective st supernatants suppress varying volunteers whole
Tagcloud (Difference) ?			1beta antagonized cultures curve cytokine cytokines extents feedback fq incubation inf lipopolysaccharide lps mediators modulation nociceptin nop normalized orphanin prepro quartile rd respective st supernatants suppress varying volunteers whole
Tagcloud (Intersection) ?