RARG and IL24

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		RARG	IL24
Gene Name		retinoic acid receptor, gamma	interleukin 24
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Transcription Factor Complex Integral Component Of Membrane	Extracellular Space Endoplasmic Reticulum
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Steroid Hormone Receptor Activity Retinoic Acid Receptor Activity Protein Binding Zinc Ion Binding Retinoid X Receptor Binding	Cytokine Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Neural Tube Closure Glandular Epithelial Cell Development Retinal Pigment Epithelium Development Growth Plate Cartilage Chondrocyte Growth Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Regulation Of Cell Size Anterior/posterior Pattern Specification Gene Expression Embryonic Camera-type Eye Development Regulation Of Myelination Negative Regulation Of Chondrocyte Differentiation Response To Retinoic Acid Embryonic Hindlimb Morphogenesis Multicellular Organism Growth Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Steroid Hormone Mediated Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter Embryonic Eye Morphogenesis Retinoic Acid Receptor Signaling Pathway Transmembrane Transport Canonical Wnt Signaling Pathway Face Development Trachea Cartilage Development Prostate Gland Epithelium Morphogenesis Harderian Gland Development Cellular Response To Retinoic Acid	Apoptotic Process Inflammatory Response Immune Response Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Negative Regulation Of Cell Migration Serine Phosphorylation Of STAT3 Protein Wound Healing Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of JAK-STAT Cascade Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-4
Pathways		Generic Transcription Pathway Signaling by Retinoic Acid Nuclear Receptor transcription pathway Orphan transporters
Drugs		Adapalene Acitretin Alitretinoin Tretinoin Tazarotene Etretinate SR11254 4-[3-Oxo-3-(5,5,8,8-Tetramethyl-5,6,7,8-Tetrahydro-Naphthalen-2-Yl)-Propenyl]-Benzoic Acid CD564 Dodecyl-Alpha-D-Maltoside BMS184394 R-3-FLUORO-4-[2-HYDROXY-2-(5,5,8,8-TETRAMETHYL-5,6,7,8,-TETRAHYDRO-NAPHTALEN-2-YL)-ACETYLAMINO]-BENZOIC ACID 3-FLUORO-4-[2-HYDROXY-2-(5,5,8,8-TETRAMETHYL-5,6,7,8,-TETRAHYDRO-NAPHTALEN-2-YL)-ACETYLAMINO]-BENZOIC ACID
Diseases
GWAS			Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		29 interactors: ACY3 EIF3I HMGA1 IL24 ITGB1BP2 LSR MAP6 MRPL12 MTMR6 NCOA1 NCOA3 NCOR1 NCOR2 NKX3-1 NR0B2 NR2F6 OIP5 PNRC1 PNRC2 RHPN2 RXRA RXRB RXRG SMAD3 SPHK1 SRC SRF TNIP1 ZNF576	5 interactors: CCR5 CLU DCD IL20RA RARG
Entrez ID		5916	11009
HPRD ID		01573	04995
Ensembl ID		ENSG00000172819	ENSG00000162892
Uniprot IDs		A8K3H3 B7Z4B4 F1D8P1 P13631	Q13007
PDB IDs		1EXA 1EXX 1FCX 1FCY 1FCZ 1FD0 2LBD 3LBD 4LBD
Enriched GO Terms of Interacting Partners?		Transcription Initiation From RNA Polymerase II Promoter Intracellular Receptor Signaling Pathway Transcription, DNA-templated Response To Steroid Hormone Transcription From RNA Polymerase II Promoter RNA Biosynthetic Process DNA-templated Transcription, Initiation Response To Hormone Gene Expression Cellular Response To Organic Substance Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Cellular Response To Steroid Hormone Stimulus Response To Lipid Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Gene Expression Regulation Of Nucleic Acid-templated Transcription Steroid Hormone Mediated Signaling Pathway Regulation Of RNA Biosynthetic Process Response To Organic Cyclic Compound Regulation Of Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Hormone-mediated Signaling Pathway RNA Metabolic Process Positive Regulation Of Transcription, DNA-templated Cellular Response To Organic Cyclic Compound Cellular Response To Hormone Stimulus Cellular Response To Lipid Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Gland Development Positive Regulation Of Cellular Biosynthetic Process Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Organ Development System Development Intracellular Steroid Hormone Receptor Signaling Pathway In Utero Embryonic Development Heart Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Chordate Embryonic Development Nucleobase-containing Compound Metabolic Process Embryo Development Ending In Birth Or Egg Hatching Negative Regulation Of Transcription, DNA-templated Cellular Response To Stimulus Negative Regulation Of Nucleic Acid-templated Transcription	Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Positive Regulation Of Tau-protein Kinase Activity Microglial Cell Proliferation Regulation Of Neuronal Signal Transduction Response To Other Organism Response To Biotic Stimulus Growth Plate Cartilage Chondrocyte Growth Positive Regulation Of Neurofibrillary Tangle Assembly Regulation Of Intrinsic Apoptotic Signaling Pathway Growth Plate Cartilage Chondrocyte Development Harderian Gland Development Response To Organic Substance Positive Regulation Of Apoptotic Signaling Pathway Central Nervous System Myelin Maintenance Chondrocyte Hypertrophy Growth Plate Cartilage Chondrocyte Differentiation Regulation Of Tau-protein Kinase Activity Negative Regulation Of Protein Homooligomerization Positive Regulation Of Inclusion Body Assembly Regulation Of Beta-amyloid Clearance Retinal Pigment Epithelium Development Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Defense Response Lacrimal Gland Development Positive Regulation Of Beta-amyloid Formation Negative Regulation Of Protein Oligomerization Negative Regulation Of Beta-amyloid Formation Regulation Of Apoptotic Process Sarcoplasmic Reticulum Calcium Ion Transport Chondrocyte Development Involved In Endochondral Bone Morphogenesis Regulation Of Cell Death Trachea Cartilage Development Chaperone-mediated Protein Complex Assembly Microglial Cell Activation Dendritic Cell Chemotaxis Negative Regulation Of Amyloid Precursor Protein Catabolic Process Cellular Response To Lipid Glial Cell Proliferation Response To Misfolded Protein Cytokine-mediated Signaling Pathway Chondrocyte Differentiation Involved In Endochondral Bone Morphogenesis Regulation Of Beta-amyloid Formation Growth Plate Cartilage Development Regulation Of Inclusion Body Assembly Reverse Cholesterol Transport Regulation Of Amyloid Precursor Protein Catabolic Process Response To Bacterium
Tagcloud ?		activating backcross chromosomes contain cosegregated enhancers fragment homology interspecific loci mapped mchr mediate none rara rarb reports responsive restriction retinoic retinoid rflvs rxr subclass syntenic terms trans variants	10b 10c 10d 11b 19l colonystimulating cxcl13 cxcl14 cxcl2 ifnalpha14 ifnalpha5 ifnalpha6 ifnalpha8 ifnepsilon1 ifnkappa ifnomega1 il13 il17beta il19 il1alpha il22 il23alpha il25 il28a il3 il31 il9 imbalanced pe
Tagcloud (Difference) ?		activating backcross chromosomes contain cosegregated enhancers fragment homology interspecific loci mapped mchr mediate none rara rarb reports responsive restriction retinoic retinoid rflvs rxr subclass syntenic terms trans variants	10b 10c 10d 11b 19l colonystimulating cxcl13 cxcl14 cxcl2 ifnalpha14 ifnalpha5 ifnalpha6 ifnalpha8 ifnepsilon1 ifnkappa ifnomega1 il13 il17beta il19 il1alpha il22 il23alpha il25 il28a il3 il31 il9 imbalanced pe
Tagcloud (Intersection) ?