RARG and PNRC2

Number of citations of the paper that reports this interaction (PubMedID 15604093)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		RARG	PNRC2
Description		retinoic acid receptor gamma	proline rich nuclear receptor coactivator 2
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Membrane RNA Polymerase II Transcription Regulator Complex	P-body Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Nuclear Receptor Activity Protein Binding Zinc Ion Binding Sequence-specific DNA Binding Metal Ion Binding Nuclear Retinoid X Receptor Binding Sequence-specific Double-stranded DNA Binding	Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Neural Tube Closure Chondrocyte Development Glandular Epithelial Cell Development Growth Plate Cartilage Development Growth Plate Cartilage Chondrocyte Growth Regulation Of DNA-templated Transcription Apoptotic Process Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Regulation Of Cell Size Anterior/posterior Pattern Specification Regulation Of Gene Expression Positive Regulation Of Gene Expression Programmed Cell Death Cell Differentiation Embryonic Camera-type Eye Development Regulation Of Myelination Negative Regulation Of Chondrocyte Differentiation Response To Retinoic Acid Embryonic Hindlimb Morphogenesis Multicellular Organism Growth Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Negative Regulation Of Cell Differentiation Regulation Of Myeloid Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Embryonic Eye Morphogenesis Retinoic Acid Receptor Signaling Pathway Reproductive Structure Development Gland Development Canonical Wnt Signaling Pathway Limb Development Face Development Bone Development Bone Morphogenesis Epithelium Development Trachea Cartilage Development Prostate Gland Epithelium Morphogenesis Negative Regulation Of Cartilage Development Harderian Gland Development Cellular Response To Retinoic Acid Stem Cell Proliferation Cellular Response To Leukemia Inhibitory Factor Negative Regulation Of Stem Cell Proliferation	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay MRNA Metabolic Process Deadenylation-independent Decapping Of Nuclear-transcribed MRNA
Pathways		Nuclear Receptor transcription pathway Signaling by Retinoic Acid Activation of anterior HOX genes in hindbrain development during early embryogenesis	Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs		Adapalene Acitretin Alitretinoin Tretinoin Tazarotene Etretinate Isotretinoin SR11254 BMS-181156 CD564 Dodecyl-Alpha-D-Maltoside BMS184394 Palovarotene LGD-1550 3-Fluoro-4-{[(2R)-2-hydroxy-2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-2-naphthalenyl)acetyl]amino}benzoic acid 3-fluoro-4-[2-hydroxy-2-(5,5,8,8-tetramethyl-5,6,7,8,-tetrahydro-naphtalen-2-yl)-acetylamino]-benzoic acid Trifarotene
Diseases
GWAS		Anthracycline-induced cardiotoxicity in childhood cancer ( 26237429) Cardiorespiratory fitness (800m run time) ( 32572135) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203)	Obesity-related traits ( 23251661)
Interacting Genes		33 interacting genes: ACY3 ARID1A BBS4 HMGA1 IL24 ITGB1BP2 LSR MAP6 MRPL12 MTMR6 MYF5 NCOA1 NCOA3 NCOR1 NCOR2 NKX3-1 NR0B2 NR2F6 OIP5 PNRC1 PNRC2 PRKAR1B PSMC5 RHPN2 RXRA RXRB RXRG S100A3 SMAD3 SMARCD3 SPHK1 TNIP1 ZNF576	23 interacting genes: APP AR BANP DCP1A ESR1 ESR2 ESRRA ESRRG FBXO7 GALK1 GLOD4 HNF4A HNF4G NR5A1 NR5A2 RARA RARG RORA RORB SPAG9 XRCC6 ZBTB16 ZBTB48
Entrez ID		5916	55629
HPRD ID		01573	17871
Ensembl ID		ENSG00000172819	ENSG00000189266
Uniprot IDs		A8K3H3 B7Z4B4 F1D8P1 P13631	Q9NPJ4
PDB IDs		1EXA 1EXX 1FCX 1FCY 1FCZ 1FD0 2LBD 3LBD 4LBD 5M24 6FX0	4B6H 5KQ1 5KQ4
Enriched GO Terms of Interacting Partners?		Nuclear Receptor Binding Chromatin Nuclear Retinoid X Receptor Binding Nuclear Retinoic Acid Receptor Binding Nuclear Receptor Activity Nuclear Receptor-mediated Signaling Pathway Retinoic Acid Receptor Signaling Pathway Intracellular Receptor Signaling Pathway Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription RNA Polymerase II Transcription Regulator Complex Retinoic Acid-responsive Element Binding Regulation Of Gene Expression Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Hormone-mediated Signaling Pathway Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Nucleoplasm Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Nucleosome Disassembly Protein-DNA Complex Disassembly Nuclear Steroid Receptor Activity Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of MiRNA Transcription Positive Regulation Of Biosynthetic Process Nuclear Thyroid Hormone Receptor Binding DNA Binding Sequence-specific DNA Binding Positive Regulation Of Developmental Process Regulation Of Response To Nutrient Levels Regulation Of Metabolic Process Regulation Of Thyroid Hormone Receptor Signaling Pathway Positive Regulation Of Vitamin D Receptor Signaling Pathway Negative Regulation Of Biosynthetic Process Transcription Coregulator Binding Positive Regulation Of Bone Mineralization Nuclear Protein Quality Control By The Ubiquitin-proteasome System Regulation Of Primary Metabolic Process Positive Regulation Of Myoblast Differentiation Somitogenesis MRNA Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II	Nuclear Receptor Activity Intracellular Receptor Signaling Pathway Sequence-specific DNA Binding DNA-binding Transcription Factor Activity Positive Regulation Of Transcription By RNA Polymerase II Hormone-mediated Signaling Pathway Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription DNA Binding Positive Regulation Of RNA Metabolic Process Estrogen Response Element Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nuclear Receptor-mediated Signaling Pathway Nuclear Steroid Receptor Activity Chromatin DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Transcription By RNA Polymerase II Steroid Binding Positive Regulation Of Macromolecule Biosynthetic Process Intracellular Signal Transduction Positive Regulation Of Biosynthetic Process Zinc Ion Binding Sequence-specific Double-stranded DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Chromatin Binding Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Transcription Coregulator Binding Regulation Of Developmental Process Regulation Of Gene Expression Negative Regulation Of RNA Metabolic Process Transcription Coactivator Binding Metal Ion Binding Regulation Of Macromolecule Biosynthetic Process Rhythmic Process Transcription Cis-regulatory Region Binding Nucleus Negative Regulation Of Nucleobase-containing Compound Metabolic Process Cellular Response To Estrogen Stimulus Regulation Of Cell Differentiation Cellular Response To Lipid
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