CD40LG and CD40

Number of citations of the paper that reports this interaction (PMID 10647992)
228

Data Source:
HPRD (in vitro, in vivo)

		CD40LG	CD40
Gene Name		CD40 ligand	CD40 molecule, TNF receptor superfamily member 5
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane	Extracellular Space Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface CD40 Receptor Complex Intracellular Membrane-bounded Organelle Extracellular Vesicular Exosome
	Molecular Function	Cytokine Activity Tumor Necrosis Factor Receptor Binding CD40 Receptor Binding	Antigen Binding Signal Transducer Activity Receptor Activity Protein Binding Enzyme Binding Ubiquitin Protein Ligase Binding
	Biological Process	Inflammatory Response Leukocyte Cell-cell Adhesion Platelet Activation B Cell Differentiation Positive Regulation Of Interleukin-12 Production B Cell Proliferation Negative Regulation Of Apoptotic Process Isotype Switching Immunoglobulin Secretion Regulation Of Immune Response Regulation Of Immunoglobulin Secretion Positive Regulation Of Endothelial Cell Apoptotic Process	Positive Regulation Of Protein Phosphorylation Immune Response-regulating Cell Surface Receptor Signaling Pathway Protein Complex Assembly Cellular Calcium Ion Homeostasis Inflammatory Response Platelet Activation Positive Regulation Of B Cell Proliferation Positive Regulation Of Interleukin-12 Production Positive Regulation Of Rac GTPase Activity B Cell Proliferation Positive Regulation Of Tyrosine Phosphorylation Of Stat1 Protein Positive Regulation Of Cdc42 GTPase Activity Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of MAP Kinase Activity Protein Kinase B Signaling Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Isotype Switching To IgG Isotypes Regulation Of Immune Response Regulation Of Immunoglobulin Secretion Positive Regulation Of NF-kappaB Transcription Factor Activity Defense Response To Virus Cellular Response To Lipopolysaccharide Cellular Response To Mechanical Stimulus Positive Regulation Of Protein Kinase C Signaling Positive Regulation Of Endothelial Cell Apoptotic Process
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Adaptive Immune System
Drugs
Diseases
GWAS			Inflammatory bowel disease ( 23128233) Kawasaki disease ( 22446961 22446962) Multiple sclerosis ( 22190364 19525955 21833088) Rheumatoid arthritis ( 18794853 20453842)
Protein-Protein Interactions		6 interactors: CD40 CD5L IGHG1 IGKC RNF128 TP53	26 interactors: BIRC2 BIRC3 CAV1 CBL CD40LG FAF1 HSPA4 HSPA8 IL4R JAK3 MAP3K8 MS4A1 NCOA6 NSMAF PIK3R1 RIPK2 SUMO1 TDP2 TRAF1 TRAF2 TRAF3 TRAF3IP2 TRAF5 TRAF6 XRCC5 XRCC6
Entrez ID		959	958
HPRD ID		02311	00178
Ensembl ID		ENSG00000102245	ENSG00000101017
Uniprot IDs		P29965 Q3L8U2	P25942
PDB IDs		1ALY 1I9R 3LKJ 3QD6	1CDF 1CZZ 1D00 1FLL 1LB6 3QD6
Enriched GO Terms of Interacting Partners?		Immune Response-regulating Cell Surface Receptor Signaling Pathway Defense Response Immune Response-regulating Signaling Pathway Lymphocyte Proliferation Mononuclear Cell Proliferation Response To Stress Positive Regulation Of Immune Response Leukocyte Proliferation Endocytosis Complement Activation, Classical Pathway Humoral Immune Response Mediated By Circulating Immunoglobulin Negative Regulation Of Macromitophagy Oligodendrocyte Apoptotic Process Complement Activation Positive Regulation Of Peptidyl-tyrosine Phosphorylation B Cell Activation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Negative Regulation Of Helicase Activity Protein Activation Cascade Immunoglobulin Mediated Immune Response B Cell Mediated Immunity Immune System Process Regulation Of Immune Response Positive Regulation Of Immune System Process Regulation Of Peptidyl-tyrosine Phosphorylation Humoral Immune Response Positive Regulation Of Cell Aging Positive Regulation Of Thymocyte Apoptotic Process Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Positive Regulation Of Isotype Switching To IgG Isotypes Mitochondrial DNA Repair Phagocytosis Leukocyte Mediated Immunity Regulation Of Mitochondrion Degradation T Cell Proliferation Involved In Immune Response B Cell Lineage Commitment Glial Cell Apoptotic Process Fc Receptor Signaling Pathway Adaptive Immune Response Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Tyrosine Phosphorylation Of Stat1 Protein Oxidative Stress-induced Premature Senescence Regulation Of Isotype Switching To IgG Isotypes Positive Regulation Of Protein Kinase C Signaling ER Overload Response Negative Regulation Of Macroautophagy Positive Regulation Of Endothelial Cell Apoptotic Process Stress-induced Premature Senescence	Immune System Process Immune Response Regulation Of Apoptotic Process Apoptotic Process Regulation Of Cell Death Programmed Cell Death Cell Death Death Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Response To Stimulus TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Regulation Of Cytokine Production Positive Regulation Of Signal Transduction Positive Regulation Of Cell-cell Adhesion Regulation Of Immune System Process Defense Response Toll-like Receptor 4 Signaling Pathway Innate Immune Response Response To Stress Regulation Of T Cell Activation Regulation Of Immune Response Positive Regulation Of Cell Activation Positive Regulation Of Immune System Process Toll-like Receptor Signaling Pathway Cellular Response To Stimulus Positive Regulation Of Cytokine Production Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Organic Substance Pattern Recognition Receptor Signaling Pathway Regulation Of Lymphocyte Activation Positive Regulation Of Intracellular Signal Transduction Innate Immune Response-activating Signal Transduction Regulation Of Innate Immune Response Activation Of Innate Immune Response Regulation Of Cell Adhesion Signaling Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Regulation Of Signal Transduction Cell Communication Regulation Of Cell Activation Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Cell Death Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Signal Transduction
Tagcloud ?		admixed ancestry aspirin cigarette comparisons contributing contributor hispanic lifestyle mediators menopausal na nhw padj partp regular rs4149578 rs5030728 rs7696175 steroidal tlr tlr1 tlr3 tlr4 tnfrsf1a tnfsf1a toll tra2 traf2	adhesion affinity bind cd40ct cytoplasmic dispensable dominantly extensive icam ikappabalpha implicated incapable intercellular jak3 kappab mediators molecule much mutants necrosis residues strongly tail traf traf2 traf3 traf5 traf6 transduction
Tagcloud (Difference) ?		admixed ancestry aspirin cigarette comparisons contributing contributor hispanic lifestyle menopausal na nhw padj partp regular rs4149578 rs5030728 rs7696175 steroidal tlr tlr1 tlr3 tlr4 tnfrsf1a tnfsf1a toll tra2	adhesion affinity bind cd40ct cytoplasmic dispensable dominantly extensive icam ikappabalpha implicated incapable intercellular jak3 kappab molecule much mutants necrosis residues strongly tail traf traf3 traf5 traf6 transduction
Tagcloud (Intersection) ?		mediators traf2