CD40LG and RNF128

Number of citations of the paper that reports this interaction (PMID 18641297)
15

Data Source:
HPRD (in vivo)

		CD40LG	RNF128
Gene Name		CD40 ligand	ring finger protein 128, E3 ubiquitin protein ligase
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane	Late Endosome Endoplasmic Reticulum Golgi Apparatus Cytoskeleton Integral Component Of Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Cytokine Activity Tumor Necrosis Factor Receptor Binding CD40 Receptor Binding	Ubiquitin-protein Transferase Activity Zinc Ion Binding Ligase Activity
	Biological Process	Inflammatory Response Leukocyte Cell-cell Adhesion Platelet Activation B Cell Differentiation Positive Regulation Of Interleukin-12 Production B Cell Proliferation Negative Regulation Of Apoptotic Process Isotype Switching Immunoglobulin Secretion Regulation Of Immune Response Regulation Of Immunoglobulin Secretion Positive Regulation Of Endothelial Cell Apoptotic Process	Protein Ubiquitination Negative Regulation Of Cytokine Biosynthetic Process
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		6 interactors: CD40 CD5L IGHG1 IGKC RNF128 TP53	13 interactors: APPBP2 CD151 CD40LG CD81 CEP76 OTUB1 TP53 UBE2D1 UBE2E1 UBE2H UBE2I UBE2N UBE2T
Entrez ID		959	79589
HPRD ID		02311	02340
Ensembl ID		ENSG00000102245	ENSG00000133135
Uniprot IDs		P29965 Q3L8U2	Q8TEB7
PDB IDs		1ALY 1I9R 3LKJ 3QD6	3ICU
Enriched GO Terms of Interacting Partners?		Immune Response-regulating Cell Surface Receptor Signaling Pathway Defense Response Immune Response-regulating Signaling Pathway Lymphocyte Proliferation Mononuclear Cell Proliferation Response To Stress Positive Regulation Of Immune Response Leukocyte Proliferation Endocytosis Complement Activation, Classical Pathway Humoral Immune Response Mediated By Circulating Immunoglobulin Negative Regulation Of Macromitophagy Oligodendrocyte Apoptotic Process Complement Activation Positive Regulation Of Peptidyl-tyrosine Phosphorylation B Cell Activation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Negative Regulation Of Helicase Activity Protein Activation Cascade Immunoglobulin Mediated Immune Response B Cell Mediated Immunity Immune System Process Regulation Of Immune Response Positive Regulation Of Immune System Process Regulation Of Peptidyl-tyrosine Phosphorylation Humoral Immune Response Positive Regulation Of Cell Aging Positive Regulation Of Thymocyte Apoptotic Process Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Positive Regulation Of Isotype Switching To IgG Isotypes Mitochondrial DNA Repair Phagocytosis Leukocyte Mediated Immunity Regulation Of Mitochondrion Degradation T Cell Proliferation Involved In Immune Response B Cell Lineage Commitment Glial Cell Apoptotic Process Fc Receptor Signaling Pathway Adaptive Immune Response Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Tyrosine Phosphorylation Of Stat1 Protein Oxidative Stress-induced Premature Senescence Regulation Of Isotype Switching To IgG Isotypes Positive Regulation Of Protein Kinase C Signaling ER Overload Response Negative Regulation Of Macroautophagy Positive Regulation Of Endothelial Cell Apoptotic Process Stress-induced Premature Senescence	Protein K48-linked Ubiquitination Protein Polyubiquitination Regulation Of Chromosome Organization Protein Ubiquitination Protein Modification By Small Protein Conjugation Regulation Of Histone Ubiquitination Regulation Of Protein Ubiquitination Regulation Of Organelle Organization Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Transferase Activity Cellular Protein Catabolic Process Positive Regulation Of Ligase Activity Protein Catabolic Process Regulation Of Ubiquitin-protein Transferase Activity Negative Regulation Of Chromosome Organization Mitotic Cell Cycle Process Negative Regulation Of Protein Ubiquitination Lymphocyte Proliferation Mononuclear Cell Proliferation Mitotic Cell Cycle Leukocyte Proliferation Regulation Of Histone Modification Positive Regulation Of Protein Ubiquitination Cellular Macromolecule Catabolic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Protein K11-linked Ubiquitination Positive Regulation Of Protein Modification Process Proteolysis Mitotic Cell Cycle Checkpoint Regulation Of Cell Cycle Process Cell Cycle Process Protein K63-linked Ubiquitination Mitotic Spindle Assembly Checkpoint DNA Metabolic Process Histone Ubiquitination Spindle Assembly Checkpoint Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Mitotic Cell Cycle Mitotic Spindle Checkpoint DNA Repair Regulation Of Cell Cycle Phase Transition Cell Cycle Checkpoint Protein Monoubiquitination Negative Regulation Of Chromosome Segregation Regulation Of Cellular Component Organization Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Tagcloud ?		admixed ancestry aspirin cigarette comparisons contributing contributor hispanic lifestyle mediators menopausal na nhw padj partp regular rs4149578 rs5030728 rs7696175 steroidal tlr tlr1 tlr3 tlr4 tnfrsf1a tnfsf1a toll tra2 traf2
Tagcloud (Difference) ?		admixed ancestry aspirin cigarette comparisons contributing contributor hispanic lifestyle mediators menopausal na nhw padj partp regular rs4149578 rs5030728 rs7696175 steroidal tlr tlr1 tlr3 tlr4 tnfrsf1a tnfsf1a toll tra2 traf2
Tagcloud (Intersection) ?