CD40LG and PHB1

Number of citations of the paper that reports this interaction (PubMedID 8070406)
79

Data Source:
BioGRID (pull down)

		CD40LG	PHB1
Description		CD40 ligand	prohibitin 1
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Golgi Apparatus Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane	Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Inner Membrane Early Endosome Plasma Membrane Cell Surface Membrane Mitochondrial Prohibitin Complex Extracellular Exosome
	Molecular Function	Signaling Receptor Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding CD40 Receptor Binding Integrin Binding Protein Binding Protein Serine/threonine Kinase Activator Activity	Complement Component C3a Binding Complement Component C3b Binding Transcription Corepressor Activity Protein Binding Enzyme Binding Proteinase Activated Receptor Binding Histone Deacetylase Binding Protein Heterodimerization Activity
	Biological Process	Regulation Of Immunoglobulin Production Regulation Of Immune System Process Inflammatory Response Immune Response Cell Communication Leukocyte Cell-cell Adhesion Cell Surface Receptor Signaling Pathway Integrin-mediated Signaling Pathway Regulation Of Gene Expression CD40 Signaling Pathway Signaling Platelet Activation B Cell Differentiation T Cell Costimulation Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-4 Production B Cell Proliferation Positive Regulation Of T Cell Proliferation Negative Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Isotype Switching Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Extrinsic Apoptotic Signaling Pathway	Negative Regulation Of Transcription By RNA Polymerase II Osteoblast Differentiation Positive Regulation Of Immunoglobulin Production Regulation Of DNA-templated Transcription Mitochondrion Organization Signal Transduction Negative Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Negative Regulation Of Transcription By Competitive Promoter Binding Negative Regulation Of Cell Growth Positive Regulation Of Interleukin-17 Production RIG-I Signaling Pathway Epigenetic Regulation Of Gene Expression B Cell Activation Negative Regulation Of Protein Catabolic Process Regulation Of Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Host-mediated Perturbation Of Viral RNA Genome Replication Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Complement Activation Symbiont Entry Into Host Cell Positive Regulation Of Smooth Muscle Cell Proliferation Protein Stabilization Progesterone Receptor Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Androgen Receptor Signaling Pathway Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Interleukin-6 DNA Biosynthetic Process T-helper 17 Type Immune Response Antiviral Innate Immune Response Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Negative Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell TNFR2 non-canonical NF-kB pathway TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	RAF activation Signaling by moderate kinase activity BRAF mutants Paradoxical activation of RAF signaling by kinase inactive BRAF Processing of SMDT1 Signaling downstream of RAS mutants
Drugs		Ruplizumab	Rocaglamide Didesmethylrocaglamide
Diseases		Combined immunodeficiencies (CIDs), including the following nine diseases: X-linked hyper IgM syndrome; CD40 deficiency hyper IgM syndrome; Purine nucleoside phosphorylase (PNP) deficiency; Omenn syndrome; MHC deficiency (HLA-class I); MHC deficiency (HLA-class II); Zap-70 deficiency; p56 Lck deficiency; CD8 deficiency
GWAS		CD40 ligand levels ( 25147954) Lymphocyte count ( 32888494) Pediatric autoimmune diseases ( 26301688) Plateletcrit ( 32888494)
Interacting Genes		7 interacting genes: CD40 CD5L IGHG1 IGKC PHB1 RNF128 TP53	27 interacting genes: ANXA2 BCAS3 CASC3 CCL5 CD40LG COX6C E2F1 ESR1 HDAC1 LONRF3 MAP1LC3A MAP3K10 MCM2 NCOR1 PTEN RAF1 RB1 RBL1 RBL2 SEC22A SIN3A SMARCA2 SMARCA4 ST14 SUMO4 TP53 XPO1
Entrez ID		959	5245
HPRD ID		02311	01454
Ensembl ID		ENSG00000102245	ENSG00000167085
Uniprot IDs		P29965	A8K401 P35232 Q53FV0
PDB IDs		1ALY 1I9R 3LKJ 3QD6 6BRB 6W9G 7SGM	8RRH
Enriched GO Terms of Interacting Partners?		Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Antigen Binding B Cell Mediated Immunity Adaptive Immune Response IgG Immunoglobulin Complex Regulation Of Immune Response Immune System Process Blood Microparticle Immune Response-regulating Signaling Pathway Immune Effector Process Lymphocyte Mediated Immunity Leukocyte Mediated Immunity Immunoglobulin Complex Regulation Of Complement Activation Positive Regulation Of Immune Response Immunoglobulin Mediated Immune Response Regulation Of Immune System Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Humoral Immune Response B Cell Receptor Signaling Pathway Positive Regulation Of Immunoglobulin Production Immune Response-activating Signaling Pathway Positive Regulation Of Complement-dependent Cytotoxicity Enzyme Binding Positive Regulation Of Immune System Process Positive Regulation Of Neuron Apoptotic Process Regulation Of Protein Stability Complement Component C3a Binding Negative Regulation Of Helicase Activity Negative Regulation Of G1 To G0 Transition Regulation Of Immunoglobulin Production Activation Of Immune Response Lymphocyte Activation Defense Response Inflammatory Response Positive Regulation Of Programmed Cell Death Immune Response Leukocyte Activation Lymphocyte Proliferation Positive Regulation Of Apoptotic Process Positive Regulation Of Interleukin-4-mediated Signaling Pathway Positive Regulation Of Protein Kinase C Signaling Mononuclear Cell Proliferation Response To Cobalamin Complement-dependent Cytotoxicity Fc-gamma Receptor I Complex Binding Mitochondrial Prohibitin Complex Histone Deacetylase Binding Proteinase Activated Receptor Binding Oligodendrocyte Apoptotic Process	Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Transcription Regulator Complex Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Lipid Kinase Activity Regulation Of Cell Cycle Phase Transition Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Chromatin Organization Chromatin Regulation Of Primary Metabolic Process Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Negative Regulation Of RNA Metabolic Process Negative Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Metabolic Process Regulation Of Cell Cycle Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Enzyme Binding Regulation Of Gene Expression Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of Macromolecule Metabolic Process Transcription Corepressor Activity Positive Regulation Of Stem Cell Population Maintenance Negative Regulation Of Cell Cycle Phase Transition Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Metabolic Process Negative Regulation Of Androgen Receptor Signaling Pathway Regulation Of Phosphorus Metabolic Process Heterochromatin Formation Rhythmic Process Transcription Repressor Complex Regulation Of Cell Cycle Negative Regulation Of Cell Cycle Process Epigenetic Regulation Of Gene Expression Circadian Behavior Promoter-specific Chromatin Binding Regulation Of Stem Cell Population Maintenance Negative Regulation Of Gene Expression Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of MiRNA Transcription
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