CD40LG and CD5L

Number of citations of the paper that reports this interaction (PubMedID 11981870)
0

Data Source:
HPRD (in vivo)

		CD40LG	CD5L
Description		CD40 ligand	CD5 molecule like
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Golgi Apparatus Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane	Extracellular Region Extracellular Space Cytoplasm Plasma Membrane Cell Surface Membrane Blood Microparticle
	Molecular Function	Signaling Receptor Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding CD40 Receptor Binding Integrin Binding Protein Binding Protein Serine/threonine Kinase Activator Activity
	Biological Process	Regulation Of Immunoglobulin Production Regulation Of Immune System Process Inflammatory Response Immune Response Cell Communication Leukocyte Cell-cell Adhesion Cell Surface Receptor Signaling Pathway Integrin-mediated Signaling Pathway Regulation Of Gene Expression CD40 Signaling Pathway Signaling Platelet Activation B Cell Differentiation T Cell Costimulation Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-4 Production B Cell Proliferation Positive Regulation Of T Cell Proliferation Negative Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Isotype Switching Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Extrinsic Apoptotic Signaling Pathway	Immune System Process Apoptotic Process Inflammatory Response Cellular Defense Response Regulation Of Complement Activation Positive Regulation Of Complement-dependent Cytotoxicity
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell TNFR2 non-canonical NF-kB pathway TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
Drugs		Ruplizumab
Diseases		Combined immunodeficiencies (CIDs), including the following nine diseases: X-linked hyper IgM syndrome; CD40 deficiency hyper IgM syndrome; Purine nucleoside phosphorylase (PNP) deficiency; Omenn syndrome; MHC deficiency (HLA-class I); MHC deficiency (HLA-class II); Zap-70 deficiency; p56 Lck deficiency; CD8 deficiency
GWAS		CD40 ligand levels ( 25147954) Lymphocyte count ( 32888494) Pediatric autoimmune diseases ( 26301688) Plateletcrit ( 32888494)
Interacting Genes		7 interacting genes: CD40 CD5L IGHG1 IGKC PHB1 RNF128 TP53	1 interacting genes: CD40LG
Entrez ID		959	922
HPRD ID		02311	03997
Ensembl ID		ENSG00000102245	ENSG00000073754
Uniprot IDs		P29965	O43866
PDB IDs		1ALY 1I9R 3LKJ 3QD6 6BRB 6W9G 7SGM	8R83 8R84 8WYR 8WYS
Enriched GO Terms of Interacting Partners?		Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Antigen Binding B Cell Mediated Immunity Adaptive Immune Response IgG Immunoglobulin Complex Regulation Of Immune Response Immune System Process Blood Microparticle Immune Response-regulating Signaling Pathway Immune Effector Process Lymphocyte Mediated Immunity Leukocyte Mediated Immunity Immunoglobulin Complex Regulation Of Complement Activation Positive Regulation Of Immune Response Immunoglobulin Mediated Immune Response Regulation Of Immune System Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Humoral Immune Response B Cell Receptor Signaling Pathway Positive Regulation Of Immunoglobulin Production Immune Response-activating Signaling Pathway Positive Regulation Of Complement-dependent Cytotoxicity Enzyme Binding Positive Regulation Of Immune System Process Positive Regulation Of Neuron Apoptotic Process Regulation Of Protein Stability Complement Component C3a Binding Negative Regulation Of Helicase Activity Negative Regulation Of G1 To G0 Transition Regulation Of Immunoglobulin Production Activation Of Immune Response Lymphocyte Activation Defense Response Inflammatory Response Positive Regulation Of Programmed Cell Death Immune Response Leukocyte Activation Lymphocyte Proliferation Positive Regulation Of Apoptotic Process Positive Regulation Of Interleukin-4-mediated Signaling Pathway Positive Regulation Of Protein Kinase C Signaling Mononuclear Cell Proliferation Response To Cobalamin Complement-dependent Cytotoxicity Fc-gamma Receptor I Complex Binding Mitochondrial Prohibitin Complex Histone Deacetylase Binding Proteinase Activated Receptor Binding Oligodendrocyte Apoptotic Process	CD40 Receptor Binding Somatic Recombination Of Immunoglobulin Gene Segments Isotype Switching Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-4 Production Somatic Cell DNA Recombination T Cell Costimulation CD40 Signaling Pathway Regulation Of Interleukin-4 Production Positive Regulation Of Interleukin-12 Production Somatic Diversification Of Immunoglobulins Involved In Immune Response Tumor Necrosis Factor Receptor Binding Somatic Diversification Of Immunoglobulins Somatic Recombination Of Immunoglobulin Genes Involved In Immune Response Positive Regulation Of Endothelial Cell Apoptotic Process B Cell Proliferation Regulation Of Endothelial Cell Apoptotic Process B Cell Activation Involved In Immune Response Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Interleukin-10 Production Platelet Activation Regulation Of Interleukin-12 Production Leukocyte Cell-cell Adhesion Protein Serine/threonine Kinase Activator Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Immunoglobulin Production Integrin-mediated Signaling Pathway B Cell Differentiation Lymphocyte Proliferation Positive Regulation Of T Cell Proliferation Mononuclear Cell Proliferation Positive Regulation Of DNA-binding Transcription Factor Activity Lymphocyte Activation Involved In Immune Response Positive Regulation Of Apoptotic Signaling Pathway Leukocyte Activation Involved In Immune Response Positive Regulation Of Lymphocyte Proliferation Leukocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Integrin Binding Cell Activation Involved In Immune Response Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Leukocyte Proliferation Regulation Of DNA-binding Transcription Factor Activity Regulation Of T Cell Proliferation B Cell Activation Regulation Of Production Of Molecular Mediator Of Immune Response Cytokine Activity Positive Regulation Of Canonical NF-kappaB Signal Transduction Lymphocyte Differentiation DNA Recombination
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