CD40LG and IGHG1

Number of citations of the paper that reports this interaction (PubMedID 11525169)
0

Data Source:
HPRD (in vitro)

		CD40LG	IGHG1
Description		CD40 ligand	immunoglobulin heavy constant gamma 1 (G1m marker)
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Golgi Apparatus Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane	Extracellular Region Extracellular Space Plasma Membrane Membrane Immunoglobulin Complex Immunoglobulin Complex, Circulating Extracellular Exosome IgG Immunoglobulin Complex Blood Microparticle
	Molecular Function	Signaling Receptor Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding CD40 Receptor Binding Integrin Binding Protein Binding Protein Serine/threonine Kinase Activator Activity	Antigen Binding Protein Binding Immunoglobulin Receptor Binding Fc-gamma Receptor I Complex Binding
	Biological Process	Regulation Of Immunoglobulin Production Regulation Of Immune System Process Inflammatory Response Immune Response Cell Communication Leukocyte Cell-cell Adhesion Cell Surface Receptor Signaling Pathway Integrin-mediated Signaling Pathway Regulation Of Gene Expression CD40 Signaling Pathway Signaling Platelet Activation B Cell Differentiation T Cell Costimulation Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-4 Production B Cell Proliferation Positive Regulation Of T Cell Proliferation Negative Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Isotype Switching Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Extrinsic Apoptotic Signaling Pathway	Antibody-dependent Cellular Cytotoxicity Adaptive Immune Response Immune System Process Complement Activation, Classical Pathway Antibacterial Humoral Response B Cell Receptor Signaling Pathway Complement-dependent Cytotoxicity
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell TNFR2 non-canonical NF-kB pathway TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
Drugs		Ruplizumab
Diseases		Combined immunodeficiencies (CIDs), including the following nine diseases: X-linked hyper IgM syndrome; CD40 deficiency hyper IgM syndrome; Purine nucleoside phosphorylase (PNP) deficiency; Omenn syndrome; MHC deficiency (HLA-class I); MHC deficiency (HLA-class II); Zap-70 deficiency; p56 Lck deficiency; CD8 deficiency
GWAS		CD40 ligand levels ( 25147954) Lymphocyte count ( 32888494) Pediatric autoimmune diseases ( 26301688) Plateletcrit ( 32888494)	Composite immunoglobulin trait (IgG/IgM) ( 28628107) IgG levels ( 23225573)
Interacting Genes		7 interacting genes: CD40 CD5L IGHG1 IGKC PHB1 RNF128 TP53	9 interacting genes: CD40LG CRYAA FCGR3A FCGR3B IGKC SWAP70 TRIM21 UCHL5 USP7
Entrez ID		959	3500
HPRD ID		02311	11755
Ensembl ID		ENSG00000102245	ENSG00000211896
Uniprot IDs		P29965
PDB IDs		1ALY 1I9R 3LKJ 3QD6 6BRB 6W9G 7SGM
Enriched GO Terms of Interacting Partners?		Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Antigen Binding B Cell Mediated Immunity Adaptive Immune Response IgG Immunoglobulin Complex Regulation Of Immune Response Immune System Process Blood Microparticle Immune Response-regulating Signaling Pathway Immune Effector Process Lymphocyte Mediated Immunity Leukocyte Mediated Immunity Immunoglobulin Complex Regulation Of Complement Activation Positive Regulation Of Immune Response Immunoglobulin Mediated Immune Response Regulation Of Immune System Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Humoral Immune Response B Cell Receptor Signaling Pathway Positive Regulation Of Immunoglobulin Production Immune Response-activating Signaling Pathway Positive Regulation Of Complement-dependent Cytotoxicity Enzyme Binding Positive Regulation Of Immune System Process Positive Regulation Of Neuron Apoptotic Process Regulation Of Protein Stability Complement Component C3a Binding Negative Regulation Of Helicase Activity Negative Regulation Of G1 To G0 Transition Regulation Of Immunoglobulin Production Activation Of Immune Response Lymphocyte Activation Defense Response Inflammatory Response Positive Regulation Of Programmed Cell Death Immune Response Leukocyte Activation Lymphocyte Proliferation Positive Regulation Of Apoptotic Process Positive Regulation Of Interleukin-4-mediated Signaling Pathway Positive Regulation Of Protein Kinase C Signaling Mononuclear Cell Proliferation Response To Cobalamin Complement-dependent Cytotoxicity Fc-gamma Receptor I Complex Binding Mitochondrial Prohibitin Complex Histone Deacetylase Binding Proteinase Activated Receptor Binding Oligodendrocyte Apoptotic Process	Immune Effector Process Immunoglobulin Mediated Immune Response B Cell Mediated Immunity IgG Receptor Activity Antibody-dependent Cellular Cytotoxicity Hypersensitivity IgG Binding Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Acute Inflammatory Response To Antigenic Stimulus Lymphocyte Mediated Immunity Regulation Of Immune System Process Leukocyte Mediated Immunity Isotype Switching Somatic Recombination Of Immunoglobulin Genes Involved In Immune Response Regulation Of DNA-binding Transcription Factor Activity Somatic Diversification Of Immunoglobulins Involved In Immune Response Inflammatory Response Immune System Process Somatic Recombination Of Immunoglobulin Gene Segments Fc-gamma Receptor Signaling Pathway Inflammatory Response To Antigenic Stimulus Immune Response Response To Stress DNA Recombination Somatic Diversification Of Immunoglobulins Somatic Cell DNA Recombination Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process DNA Metabolic Process Fc Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Adaptive Immune Response Acute Inflammatory Response Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process B Cell Activation Involved In Immune Response External Side Of Plasma Membrane Leukocyte Mediated Cytotoxicity Regulation Of Protein Stability Negative Regulation Of Proteolysis Involved In Protein Catabolic Process CD40 Receptor Binding Regulation Of Immune Response Immune Response-regulating Signaling Pathway Low-affinity IgG Receptor Activity Immune Receptor Activity Cysteine-type Deubiquitinase Activity Negative Regulation Of Cell-cell Adhesion Mediated By Integrin Autophagosome Assembly Protein Deubiquitination Positive Regulation Of Immune System Process Autophagosome Organization
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