MPDU1 and LSM1

Number of citations of the paper that reports this interaction (PubMedID 15231747)
47

Data Source:
BioGRID (two hybrid)

		MPDU1	LSM1
Description		mannose-P-dolichol utilization defect 1	LSM1 homolog, mRNA degradation associated
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane Membrane	P-body Nucleus Cytoplasm Cytosol Lsm1-7-Pat1 Complex Ribonucleoprotein Complex
	Molecular Function	Protein Binding	RNA Binding MRNA Binding Protein Binding
	Biological Process	Protein Folding Dolichol-linked Oligosaccharide Biosynthetic Process Oligosaccharide Biosynthetic Process	Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA RNA Splicing, Via Transesterification Reactions Nuclear-transcribed MRNA Catabolic Process MRNA Processing RNA Splicing Stem Cell Population Maintenance Neuron Differentiation Negative Regulation Of Neuron Differentiation Histone MRNA Catabolic Process
Pathways		Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein Defective MPDU1 causes CDG-1f	mRNA decay by 5' to 3' exoribonuclease mRNA decay by 5' to 3' exoribonuclease
Drugs
Diseases		Congenital disorders of glycosylation (CDG) type I
GWAS		Brain morphology (MOSTest) ( 32665545) Hemoglobin levels ( 32327693) IgA nephropathy ( 22197929) Refractive error ( 32231278)	Autism spectrum disorder or schizophrenia ( 28540026) Schizophrenia ( 22037555 28991256 29483656)
Interacting Genes		3 interacting genes: LSM1 MANBAL SHBG	32 interacting genes: AGR2 AGR3 BEX5 CLIC1 DAPL1 EXOSC6 EXOSC8 GLUD1 GRHPR GSTA4 HSP90AA1 LSM2 LSM3 LSM5 LSM6 LSM7 MCCD1 MPDU1 N4BP1 NARS1 NDUFAF3 PSMB5 PSMB8 PTPRC RRP1B SMN1 TCL1B TFCP2 TMEM214 UPF2 UXT VPS11
Entrez ID		9526	27257
HPRD ID		04951	06281
Ensembl ID		ENSG00000129255	ENSG00000175324
Uniprot IDs		A0A0S2Z4W8 B4DLH7 J3QW43 O75352	A0A0S2Z590 O15116
PDB IDs
Enriched GO Terms of Interacting Partners?		Androgen Binding Lsm1-7-Pat1 Complex Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA RNA Decapping MRNA Methylguanosine-cap Decapping Histone MRNA Catabolic Process Histone MRNA Metabolic Process Steroid Binding	Lsm2-8 Complex U6 SnRNP Lsm1-7-Pat1 Complex MRNA Catabolic Process MRNA Metabolic Process U4/U6 X U5 Tri-snRNP Complex U2-type Precatalytic Spliceosome RNA Catabolic Process RNA Splicing, Via Transesterification Reactions Nucleobase-containing Compound Catabolic Process RNA Splicing RNA Metabolic Process RNA Binding MRNA Processing Macromolecule Catabolic Process Spliceosomal Complex RNA Processing Negative Regulation Of Gene Expression MRNA Splicing, Via Spliceosome Nuclear-transcribed MRNA Catabolic Process Nucleic Acid Metabolic Process U4 SnRNA 3'-end Processing Threonine-type Endopeptidase Activity Dystroglycan Binding Nucleolar Exosome (RNase Complex) Catabolic Process Proteasome Core Complex, Beta-subunit Complex Nuclear MRNA Surveillance U6 SnRNA Binding Cytoplasmic Exosome (RNase Complex) RNA Exonuclease Activity RRNA Catabolic Process Nuclear Exosome (RNase Complex) Exosome (RNase Complex) Macromolecule Metabolic Process Precatalytic Spliceosome Catalytic Step 2 Spliceosome Proteasome Core Complex Nucleobase-containing Compound Metabolic Process RRNA Processing Ribonucleoprotein Complex SnRNA 3'-end Processing P-body RRNA Metabolic Process Positive Regulation Of Isotype Switching CTP Binding DATP Binding Protein Folding Chaperone Complex Plasma Membrane Raft Distribution Hydroxypyruvate Reductase [NAD(P)H] Activity
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?