L3MBTL1 and SETD7

Number of citations of the paper that reports this interaction (PubMedID 18408754)
52

Data Source:
BioGRID (pull down)

		L3MBTL1	SETD7
Description		L3MBTL histone methyl-lysine binding protein 1	SET domain containing 7, histone lysine methyltransferase
Image
GO Annotations	Cellular Component	Chromatin Condensed Chromosome Nucleus Nucleoplasm Nucleolus Chromatin Lock Complex	Nucleus Nucleoplasm Chromosome Nucleolus
	Molecular Function	Chromatin Binding Protein Binding Zinc Ion Binding Nucleosome Binding SAM Domain Binding Histone Binding Identical Protein Binding Metal Ion Binding Histone H4K20me2 Reader Activity Histone H1 Reader Activity	P53 Binding Chromatin Binding Protein Binding Methyltransferase Activity Protein-lysine N-methyltransferase Activity Transferase Activity Histone Methyltransferase Activity Histone H3 Methyltransferase Activity Histone H3K4 Monomethyltransferase Activity
	Biological Process	Chromatin Organization Regulation Of DNA-templated Transcription Regulation Of Mitotic Nuclear Division Hemopoiesis Heterochromatin Formation Regulation Of Megakaryocyte Differentiation Negative Regulation Of DNA-templated Transcription Regulation Of Cell Cycle Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Constitutive Heterochromatin Formation	Regulation Of DNA Repair Chromatin Organization Chromatin Remodeling Regulation Of DNA-templated Transcription DNA Damage Response Peptidyl-lysine Monomethylation Peptidyl-lysine Dimethylation Methylation Response To Ethanol Positive Regulation Of DNA-templated Transcription Heterochromatin Organization Response To Alcohol
Pathways		Regulation of TP53 Activity through Methylation	PKMTs methylate histone lysines
Drugs		2-(N-morpholino)ethanesulfonic acid	S-adenosyl-L-homocysteine
Diseases
GWAS		Antibody level in response to infection ( 25758998) Daytime sleep phenotypes ( 27126917)	Diastolic blood pressure in combination therapy (beta blocker and thiazide diuretic) ( 29097388) Ferritin levels ( 33491795) Lean body mass ( 28552196) Salty taste perception in obesity with metabolic syndrome ( 31005965) Serum lycopene concentrations ( 26861389)
Interacting Genes		8 interacting genes: CBX3 ETV6 ETV7 FXR2 H1-5 H4C16 RB1 SETD7	32 interacting genes: A1BG ATG16L1 DNMT1 E2F1 ESR1 H3-3A H3-4 H3C1 H3C14 H4C1 HCFC1 KLF4 L3MBTL1 MDM2 NR2F2 OGT OTUB1 PPP1R12A PRKAR1A RELA RIOK1 SERTAD1 SIRT1 SMAD7 SOX2 STAT3 STEAP3 TAF10 TAF7 TP53 TRIM21 UBC
Entrez ID		26013	80854
HPRD ID		16387	16226
Ensembl ID		ENSG00000185513	ENSG00000145391
Uniprot IDs		A0A0A0MRR4 A0A3B3ISS0 A0A3F2YNZ1 B0QYN5 Q9Y468	B5MCZ8 D6RJA0 Q8WTS6
PDB IDs		1OYX 1OZ2 1OZ3 2PQW 2RHI 2RHU 2RHX 2RHY 2RHZ 2RI2 2RI3 2RI5 2RJC 2RJD 2RJE 2RJF 3OQ5 3P8H 3UWN 6BYB	1H3I 1MT6 1MUF 1N6A 1N6C 1O9S 1XQH 2F69 3CBM 3CBO 3CBP 3M53 3M54 3M55 3M56 3M57 3M58 3M59 3M5A 3OS5 3VUZ 3VV0 4E47 4J7F 4J7I 4J83 4J8O 4JDS 4JLG 5AYF 5EG2 5YLT
Enriched GO Terms of Interacting Partners?		Chromatin Lock Complex Chromatin Remodeling Chromatin Organization Chromatin Negative Regulation Of DNA-templated Transcription Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of RNA Metabolic Process Heterochromatin Protein Localization To Chromosome, Centromeric Region Negative Regulation Of RNA Metabolic Process Euchromatin Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Thermosensory Behavior Negative Regulation Of Macromolecule Metabolic Process Chromosome Organization RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Structural Constituent Of Chromatin Negative Regulation Of Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Vitellogenesis Regulation Of RNA Biosynthetic Process Nucleosome Nucleosome Assembly Nucleosome Organization Protein Localization To Chromosome Sister Chromatid Biorientation Maintenance Of Mitotic Sister Chromatid Cohesion Regulation Of Lipid Kinase Activity Positive Regulation Of Collagen Fibril Organization Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Senescence-associated Heterochromatin Focus DNA Binding Nucleus Heterochromatin Formation Regulation Of Gene Expression Glial Cell Apoptotic Process Rb-E2F Complex Peptidyl-lysine Dimethylation Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Negative Regulation Of Myofibroblast Differentiation Negative Regulation Of Hepatocyte Apoptotic Process Regulation Of Centromere Complex Assembly Potassium:chloride Symporter Activity Enucleate Erythrocyte Differentiation Negative Regulation Of Gene Expression, Epigenetic	Chromatin Organization Nucleoplasm Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Protein-containing Complex Negative Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Regulator Complex Regulation Of RNA Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Biosynthetic Process Chromatin Remodeling Protein-DNA Complex Assembly Negative Regulation Of Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Regulation Of Gene Expression Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Gene Expression DNA-templated Transcription Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Developmental Process Positive Regulation Of Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Promoter-specific Chromatin Binding Positive Regulation Of Biosynthetic Process Regulation Of MiRNA Transcription Chromatin DNA Binding Regulation Of Cell Differentiation Nucleobase-containing Compound Biosynthetic Process Regulation Of Developmental Process Transcription Cis-regulatory Region Binding Structural Constituent Of Chromatin Chromatin DNA Binding Regulation Of MiRNA Metabolic Process Negative Regulation Of Signal Transduction
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