ADAMTS4 and BCAN

Number of citations of the paper that reports this interaction (PubMedID 10986281)
0

Data Source:
HPRD (in vitro)

		ADAMTS4	BCAN
Description		ADAM metallopeptidase with thrombospondin type 1 motif 4	brevican
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nuclear Speck Extracellular Matrix	Extracellular Region Extracellular Space Golgi Lumen Membrane Extracellular Matrix Lysosomal Lumen Synapse Perineuronal Net Side Of Membrane Glutamatergic Synapse
	Molecular Function	Protease Binding Metalloendopeptidase Activity Protein Binding Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity Metal Ion Binding	Protein Binding Hyaluronic Acid Binding Carbohydrate Binding
	Biological Process	Skeletal System Development Proteolysis Extracellular Matrix Disassembly Proteoglycan Catabolic Process Extracellular Matrix Organization Defense Response To Bacterium	Skeletal System Development Cell Adhesion Central Nervous System Development Hippocampus Development Synapse Maturation
Pathways		Degradation of the extracellular matrix Degradation of the extracellular matrix Defective B3GALTL causes PpS O-glycosylation of TSR domain-containing proteins	Degradation of the extracellular matrix Glycosaminoglycan-protein linkage region biosynthesis CS-GAG biosynthesis DS-GAG biosynthesis CS/DS degradation ECM proteoglycans Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Defective CHST14 causes EDS, musculocontractural type Defective CHSY1 causes TPBS Defective B3GALT6 causes EDSP2 and SEMDJL1
Drugs
Diseases
GWAS		Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Asthma ( 27182965 31361310 31619474) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Family history of Alzheimer's disease ( 30617256) HDL cholesterol levels ( 32203549) Monocyte percentage of white cells ( 27863252 32888494)	Blood protein levels ( 30072576)
Interacting Genes		11 interacting genes: ACAN BCAN FN1 FURIN HP MT2A SERPINA1 SERPINA3 SRPX2 YTHDC1 ZBTB16	10 interacting genes: ADAMTS4 FBLN2 MMP1 MMP10 MMP13 MMP2 MMP3 MMP7 MMP8 TNR
Entrez ID		9507	63827
HPRD ID		04853	02644
Ensembl ID		ENSG00000158859	ENSG00000132692
Uniprot IDs		O75173	Q96GW7
PDB IDs		2RJP 3B2Z 4WK7 4WKE 4WKI
Enriched GO Terms of Interacting Partners?		Acute-phase Response Acute Inflammatory Response Extracellular Matrix Extracellular Space Extracellular Region Platelet Alpha Granule Lumen Perineuronal Net Serine-type Endopeptidase Inhibitor Activity Negative Regulation Of Transforming Growth Factor Beta Production Golgi Lumen Protease Binding Extracellular Matrix Structural Constituent Blood Microparticle Hyaluronic Acid Binding Central Nervous System Development Skeletal System Development Inflammatory Response Zymogen Activation Negative Regulation Of Nerve Growth Factor Production Dibasic Protein Processing Zymogen Inhibition Hepatocyte Growth Factor Binding Protein Maturation Negative Regulation Of Hydrogen Peroxide Catabolic Process Golgi Apparatus Subcompartment Regulation Of Nerve Growth Factor Production Negative Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Nerve Growth Factor Production Negative Regulation Of Neurotrophin Production Type 2 Angiotensin Receptor Binding Primary Follicle Stage Lysosomal Lumen Cell Adhesion Negative Regulation Of Monocyte Activation Positive Regulation Of Substrate-dependent Cell Migration, Cell Attachment To Substrate Negative Regulation Of Receptor Catabolic Process Male Germ-line Stem Cell Asymmetric Division Mammalian Oogenesis Stage Peptidase Inhibitor Activity Calcium-independent Cell-matrix Adhesion Cellular Response To Erythropoietin Viral Translation Viral Life Cycle Germ-line Stem Cell Division Positive Regulation Of NK T Cell Differentiation MRNA Alternative Polyadenylation System Development Hemoglobin Binding Response To Erythropoietin Cytokine Precursor Processing	Extracellular Matrix Disassembly Collagen Catabolic Process Metalloendopeptidase Activity Extracellular Matrix Extracellular Structure Organization Extracellular Matrix Organization Metallopeptidase Activity Collagen Metabolic Process Endopeptidase Activity Serine-type Endopeptidase Activity Peptidase Activity Extracellular Region Cellular Response To UV-A Proteolysis Response To UV-A Extracellular Space Hydrolase Activity Catabolic Process Zinc Ion Binding Response To Amyloid-beta Cellular Response To UV Protein Metabolic Process Cellular Response To Light Stimulus Response To UV Cellular Response To Radiation Metal Ion Binding Endodermal Cell Differentiation Regulation Of Neuroinflammatory Response Antibacterial Peptide Secretion Response To Light Stimulus Cellular Response To Amino Acid Stimulus Macromolecule Metabolic Process Negative Regulation Of Axon Extension Involved In Regeneration Response To Radiation Regulation Of Cell Migration Cellular Response To Reactive Oxygen Species Antibacterial Peptide Biosynthetic Process Axon Extension Involved In Regeneration Regulation Of Cell Motility Response To Amino Acid Cellular Response To Lipid Regulation Of Locomotion Positive Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Tenascin Complex Neuroblast Migration Ossification Intramembranous Ossification Blood Vessel Maturation Peripheral Nervous System Axon Regeneration Response To Reactive Oxygen Species
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