ADAMTS4 and HP

Number of citations of the paper that reports this interaction (PMID 16099106)
5

Data Source:
HPRD (two hybrid)

		ADAMTS4	HP
Gene Name		ADAM metallopeptidase with thrombospondin type 1 motif, 4	haptoglobin
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Proteinaceous Extracellular Matrix Extracellular Space Extracellular Matrix	Extracellular Region Extracellular Space Haptoglobin-hemoglobin Complex Extracellular Vesicular Exosome Endocytic Vesicle Lumen Blood Microparticle
	Molecular Function	Protease Binding Metalloendopeptidase Activity Protein Binding Peptidase Activity Metallopeptidase Activity Zinc Ion Binding	Catalytic Activity Protein Binding Antioxidant Activity Hemoglobin Binding
	Biological Process	Skeletal System Development Proteolysis Extracellular Matrix Disassembly Extracellular Matrix Organization Defense Response To Bacterium	Immune System Process Receptor-mediated Endocytosis Defense Response Acute-phase Response Metabolic Process Positive Regulation Of Cell Death Response To Hydrogen Peroxide Defense Response To Bacterium Negative Regulation Of Oxidoreductase Activity Negative Regulation Of Hydrogen Peroxide Catabolic Process
Pathways		Post-translational protein modification O-glycosylation of TSR domain-containing proteins Degradation of the extracellular matrix O-linked glycosylation	Scavenging of heme from plasma
Drugs
Diseases
GWAS			Cholesterol, total ( 20686565) Haptoglobin levels ( 22403646) LDL cholesterol ( 20686565) Metabolite levels ( 22916037)
Protein-Protein Interactions		11 interactors: ACAN BCAN FN1 FURIN HP MT2A SERPINA1 SERPINA3 SRPX2 YTHDC1 ZBTB16	20 interactors: ADAMTS4 ATP7B C1RL CD163 CD22 GADD45G GRB2 HBB ITGAM ITGB2 LAMC3 MVP RBBP6 RPL11 SMAD3 TBL1X TGM2 TP63 VKORC1 WASL
Entrez ID		9507	3240
HPRD ID		04853	00772
Ensembl ID			ENSG00000257017
Uniprot IDs		O75173	P00738 Q6PEJ8
PDB IDs		2RJP 3B2Z
Enriched GO Terms of Interacting Partners?		Acute-phase Response Acute Inflammatory Response Extracellular Matrix Disassembly Extracellular Matrix Organization Extracellular Structure Organization Regulation Of Peptidase Activity Inflammatory Response Pathogenesis Regulation Of Proteolysis Defense Response Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Proteoglycan Biosynthetic Process Glycosaminoglycan Catabolic Process Negative Regulation Of Catalytic Activity Negative Regulation Of Proteolysis Platelet Degranulation Negative Regulation Of Hydrogen Peroxide Catabolic Process Negative Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Response To Methanol Negative Regulation Of Protein Processing Regulation Of Endopeptidase Activity Negative Regulation Of Hydrolase Activity Regulation Of Protein Processing Nerve Growth Factor Production Response To Triglyceride Glycosaminoglycan Biosynthetic Process Proteoglycan Metabolic Process Response To Inorganic Substance Negative Regulation Of Transforming Growth Factor Beta1 Production Negative Regulation Of Receptor Catabolic Process Secretion By Cell Cell Adhesion Negative Regulation Of Cellular Metabolic Process Response To Chromate Cellular Response To Erythropoietin Nerve Growth Factor Processing Calcium-independent Cell-matrix Adhesion Negative Regulation Of Hydrogen Peroxide Metabolic Process Skeletal System Development Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Cellular Response To Interleukin-3 Positive Regulation Of NK T Cell Differentiation Negative Regulation Of Transforming Growth Factor Beta Production Negative Regulation Of Serine-type Endopeptidase Activity Male Germ-line Stem Cell Asymmetric Division Secretion Regulation Of Catalytic Activity Glycosaminoglycan Metabolic Process Negative Regulation Of Serine-type Peptidase Activity	Regulation Of Body Fluid Levels Response To Stress Wound Healing Multicellular Organismal Development Response To Wounding Blood Coagulation Hemostasis Response To Stimulus Tissue Development Leukocyte Migration Involved In Inflammatory Response Positive Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Immune Response Defense Response Developmental Process Positive Regulation Of Cell Death Anatomical Structure Development Homotypic Cell-cell Adhesion Protein Complex Assembly Positive Regulation Of Immune Response System Development Endocytosis Cellular Extravasation Activated T Cell Proliferation Cell Activation Extracellular Matrix Organization Extracellular Structure Organization Regulation Of Reactive Oxygen Species Metabolic Process Cell Adhesion Organ Development Protein Oligomerization Innate Immune Response Positive Regulation Of Nitric Oxide Biosynthetic Process Cell Surface Receptor Signaling Pathway Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Immune Response Regulation Of Immune System Process Immune Response-regulating Signaling Pathway Positive Regulation Of Cytoskeleton Organization Gland Development Neutrophil Chemotaxis Positive Regulation Of Immune System Process Morphogenesis Of An Epithelium Neutrophil Migration Leukocyte Migration Single Organismal Cell-cell Adhesion Positive Regulation Of Transforming Growth Factor Beta3 Production Epidermal Cell Division Ectoderm And Mesoderm Interaction Granulocyte Chemotaxis Regulation Of Nitric Oxide Biosynthetic Process
Tagcloud ?		affymetrix continues crabp2 depleted differentiating directs driving exons intergenic introns luciferase master mineralization networks occupancy osteoblast osteoblastogenesis osteoblasts osteogenesis partitioned peaks performing regions remodelers runx2 termination throughput tnfrsf19 turnover	antibody cd19 cd3 cd4 cd8 controversial dialysis dr hemodialysis hla hs humoral iii miv multivalent parameters percentages phenomenon restore session strikingly subgroups supplementation supplemented uremia vaccinated vaccination zn znso4
Tagcloud (Difference) ?		affymetrix continues crabp2 depleted differentiating directs driving exons intergenic introns luciferase master mineralization networks occupancy osteoblast osteoblastogenesis osteoblasts osteogenesis partitioned peaks performing regions remodelers runx2 termination throughput tnfrsf19 turnover	antibody cd19 cd3 cd4 cd8 controversial dialysis dr hemodialysis hla hs humoral iii miv multivalent parameters percentages phenomenon restore session strikingly subgroups supplementation supplemented uremia vaccinated vaccination zn znso4
Tagcloud (Intersection) ?