BCAN

Description		brevican
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Golgi Lumen Membrane Extracellular Matrix Lysosomal Lumen Synapse Perineuronal Net Side Of Membrane Glutamatergic Synapse
	Molecular Function	Protein Binding Hyaluronic Acid Binding Carbohydrate Binding
	Biological Process	Skeletal System Development Cell Adhesion Central Nervous System Development Hippocampus Development Synapse Maturation
Pathways		Degradation of the extracellular matrix Glycosaminoglycan-protein linkage region biosynthesis CS-GAG biosynthesis DS-GAG biosynthesis CS/DS degradation ECM proteoglycans Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Defective CHST14 causes EDS, musculocontractural type Defective CHSY1 causes TPBS Defective B3GALT6 causes EDSP2 and SEMDJL1
Drugs
Diseases
GWAS		Blood protein levels ( 30072576)
Interacting Genes		10 interacting genes: ADAMTS4 FBLN2 MMP1 MMP10 MMP13 MMP2 MMP3 MMP7 MMP8 TNR
Entrez ID		63827
HPRD ID		02644
Ensembl ID		ENSG00000132692
Uniprot IDs		Q96GW7
PDB IDs
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Disassembly Collagen Catabolic Process Metalloendopeptidase Activity Extracellular Matrix Extracellular Structure Organization Extracellular Matrix Organization Metallopeptidase Activity Collagen Metabolic Process Endopeptidase Activity Serine-type Endopeptidase Activity Peptidase Activity Extracellular Region Cellular Response To UV-A Proteolysis Response To UV-A Extracellular Space Hydrolase Activity Catabolic Process Zinc Ion Binding Response To Amyloid-beta Cellular Response To UV Protein Metabolic Process Cellular Response To Light Stimulus Response To UV Cellular Response To Radiation Metal Ion Binding Endodermal Cell Differentiation Regulation Of Neuroinflammatory Response Antibacterial Peptide Secretion Response To Light Stimulus Cellular Response To Amino Acid Stimulus Macromolecule Metabolic Process Negative Regulation Of Axon Extension Involved In Regeneration Response To Radiation Regulation Of Cell Migration Cellular Response To Reactive Oxygen Species Antibacterial Peptide Biosynthetic Process Axon Extension Involved In Regeneration Regulation Of Cell Motility Response To Amino Acid Cellular Response To Lipid Regulation Of Locomotion Positive Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Tenascin Complex Neuroblast Migration Ossification Intramembranous Ossification Blood Vessel Maturation Peripheral Nervous System Axon Regeneration Response To Reactive Oxygen Species
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