BCAN and MMP1

Number of citations of the paper that reports this interaction (PMID 10986281)
28

Data Source:
HPRD (in vitro)

		BCAN	MMP1
Gene Name		brevican	matrix metallopeptidase 1 (interstitial collagenase)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Proteinaceous Extracellular Matrix Golgi Lumen Anchored Component Of Membrane Lysosomal Lumen	Extracellular Region Proteinaceous Extracellular Matrix
	Molecular Function	Extracellular Matrix Structural Constituent Hyaluronic Acid Binding Carbohydrate Binding	Endopeptidase Activity Metalloendopeptidase Activity Calcium Ion Binding Zinc Ion Binding
	Biological Process	Skeletal System Development Carbohydrate Metabolic Process Cell Adhesion Central Nervous System Development Pathogenesis Hippocampus Development Extracellular Matrix Disassembly Extracellular Matrix Organization Glycosaminoglycan Metabolic Process Chondroitin Sulfate Metabolic Process Chondroitin Sulfate Biosynthetic Process Chondroitin Sulfate Catabolic Process Dermatan Sulfate Biosynthetic Process Small Molecule Metabolic Process	Proteolysis Blood Coagulation Viral Process Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process Positive Regulation Of Protein Oligomerization Cellular Protein Metabolic Process Leukocyte Migration
Pathways		MPS IIIB - Sanfilippo syndrome B Diseases of glycosylation Heparan sulfate/heparin (HS-GAG) metabolism Defective B4GALT7 causes EDS, progeroid type MPS I - Hurler syndrome MPS IX - Natowicz syndrome Chondroitin sulfate/dermatan sulfate metabolism CS/DS degradation Defective SLC26A2 causes chondrodysplasias Glycosaminoglycan metabolism Degradation of the extracellular matrix Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective CHST14 causes EDS, musculocontractural type Defective PAPSS2 causes SEMD-PA MPS IIIA - Sanfilippo syndrome A Myoclonic epilepsy of Lafora ECM proteoglycans Defective CHST6 causes MCDC1 Glycogen storage diseases MPS IIID - Sanfilippo syndrome D A tetrasaccharide linker sequence is required for GAG synthesis Chondroitin sulfate biosynthesis MPS IIIC - Sanfilippo syndrome C Diseases associated with glycosaminoglycan metabolism Mucopolysaccharidoses Defective EXT2 causes exostoses 2 MPS II - Hunter syndrome Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Defective EXT1 causes exostoses 1, TRPS2 and CHDS MPS IV - Morquio syndrome A Dermatan sulfate biosynthesis MPS IV - Morquio syndrome B Defective CHSY1 causes TPBS MPS VII - Sly syndrome Metabolism of carbohydrates MPS VI - Maroteaux-Lamy syndrome	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Collagen degradation Activation of Matrix Metalloproteinases Degradation of the extracellular matrix Basigin interactions Cell surface interactions at the vascular wall
Drugs			Marimastat N-HYDROXY-2(R)-[[(4-METHOXYPHENYL)SULFONYL](3-PICOLYL)AMINO]-3-METHYLBUTANAMIDE HYDROCHLORIDE N-[3-(N\'-HYDROXYCARBOXAMIDO)-2-(2-METHYLPROPYL)-PROPANOYL]-O-TYROSINE-N-METHYLAMIDE METHYLAMINO-PHENYLALANYL-LEUCYL-HYDROXAMIC ACID [[1-[N-HYDROXY-ACETAMIDYL]-3-METHYL-BUTYL]-CARBONYL-LEUCINYL]-ALANINE ETHYL ESTER N-HYDROXY-2-[4-(4-PHENOXY-BENZENESULFONYL)-TETRAHYDRO-PYRAN-4-YL]-ACETAMIDE
Diseases
GWAS
Protein-Protein Interactions		10 interactors: ADAMTS4 FBLN2 MMP1 MMP10 MMP13 MMP2 MMP3 MMP7 MMP8 TNR	17 interactors: ACAN BCAN BSG CCL13 CCL2 CCL7 CD44 CMA1 COL2A1 IGFBP3 ITGA2 MMP7 SERPINA3 SOX8 TFPI TIMP1 TNFSF11
Entrez ID		63827	4312
HPRD ID		02644	00384
Ensembl ID		ENSG00000132692	ENSG00000196611
Uniprot IDs		Q96GW7	B4DN15 P03956 Q53G95
PDB IDs			1AYK 1CGE 1CGF 1CGL 1HFC 1SU3 2AYK 2CLT 2J0T 2TCL 3AYK 3SHI 4AUO 4AYK 966C
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Organization Extracellular Structure Organization Extracellular Matrix Disassembly Collagen Catabolic Process Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Proteolysis Catabolic Process Positive Regulation Of Protein Oligomerization Regulation Of Protein Oligomerization Endodermal Cell Differentiation Endoderm Formation Protein Metabolic Process Cellular Response To Amino Acid Stimulus Antibacterial Peptide Secretion Antibacterial Peptide Biosynthetic Process Negative Regulation Of Axon Extension Involved In Regeneration Endoderm Development Response To Amino Acid Formation Of Primary Germ Layer Skeletal System Development Negative Regulation Of Hydrogen Peroxide Metabolic Process Positive Regulation Of Protein Complex Assembly Cellular Response To Acid Chemical Gastrulation Defense Response To Bacterium Positive Regulation Of Transmission Of Nerve Impulse Negative Regulation Of Axon Regeneration Positive Regulation Of Oxidative Stress-induced Cell Death Intramembranous Ossification Regulation Of Hydrogen Peroxide Metabolic Process Bone Trabecula Formation Response To External Stimulus Regulation Of Transmission Of Nerve Impulse Locomotory Exploration Behavior Blood Vessel Maturation Skeletal System Morphogenesis Cellular Response To Nitric Oxide Ossification Neuron Cell-cell Adhesion Response To Nitric Oxide Positive Regulation Of Cellular Component Biogenesis Bone Trabecula Morphogenesis Regulation Of Axon Regeneration Regulation Of Protein Complex Assembly Growth Plate Cartilage Development Response To Stress Positive Regulation Of Synaptic Transmission, Glutamatergic Cellular Response To Reactive Nitrogen Species	Extracellular Matrix Disassembly Extracellular Matrix Organization Extracellular Structure Organization Leukocyte Migration Cell Migration Locomotion Cell Motility Monocyte Chemotaxis Organ Morphogenesis Movement Of Cell Or Subcellular Component Leukocyte Chemotaxis Chemotaxis Response To Stress Cell Chemotaxis Regulation Of Protein Metabolic Process Response To Wounding Organ Development Glycosaminoglycan Catabolic Process Blood Coagulation Inflammatory Response Hemostasis Granulocyte Chemotaxis Eosinophil Chemotaxis Response To Organic Substance Eosinophil Migration Connective Tissue Development Homeostatic Process Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Endopeptidase Activity Positive Regulation Of Leukocyte Migration Negative Regulation Of Peptidase Activity Regulation Of Body Fluid Levels Developmental Process Ossification Regulation Of Cell Migration Wound Healing Proteoglycan Metabolic Process Calcium Ion Homeostasis Regulation Of Cell Motility Positive Regulation Of Chemotaxis Response To Stimulus Regulation Of Leukocyte Migration Regulation Of Locomotion Negative Regulation Of Proteolysis Regulation Of Cellular Component Movement Positive Regulation Of Behavior Regulation Of Catalytic Activity Tissue Development Negative Regulation Of Protein Processing Anatomical Structure Morphogenesis
Tagcloud ?		abundant astrocytes basic cg clustering differentiated diverse embryos enriched fbln2 forebrain foundation functionally glial itih3 mesenchymal ncam1 nervous networks neural nsc nscs ontology regulators rich tnr transcriptomes vcan wnt	artp calculating chief convergence dusp2 hrgg il2ra il6 il8ra il8rb infgr1 irf2 map3k10 merits nfkb1a nos2a partp pik3ca polygenic pttrnd raf1 rectal runx3 sepx1 smad3 soc strongest truncation tyk2
Tagcloud (Difference) ?		abundant astrocytes basic cg clustering differentiated diverse embryos enriched fbln2 forebrain foundation functionally glial itih3 mesenchymal ncam1 nervous networks neural nsc nscs ontology regulators rich tnr transcriptomes vcan wnt	artp calculating chief convergence dusp2 hrgg il2ra il6 il8ra il8rb infgr1 irf2 map3k10 merits nfkb1a nos2a partp pik3ca polygenic pttrnd raf1 rectal runx3 sepx1 smad3 soc strongest truncation tyk2
Tagcloud (Intersection) ?