ADAMTS4 and MT2A

Number of citations: 0 (PubMedID 16099106)
Data Source: HPRD (two hybrid)

		ADAMTS4	MT2A
Name		ADAM metallopeptidase with thrombospondin type 1 motif 4	metallothionein 2A
Structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nuclear Speck Extracellular Matrix	Nucleus Cytoplasm Cytosol
	Molecular Function	Protease Binding Metalloendopeptidase Activity Protein Binding Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity Metal Ion Binding	Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Skeletal System Development Proteolysis Extracellular Matrix Disassembly Proteoglycan Catabolic Process Extracellular Matrix Organization Defense Response To Bacterium	Intracellular Copper Ion Homeostasis Intracellular Zinc Ion Homeostasis Detoxification Of Copper Ion Cellular Response To Interleukin-3 Cellular Response To Erythropoietin Negative Regulation Of Growth Cellular Response To Cadmium Ion Cellular Response To Copper Ion Cellular Response To Zinc Ion
Pathways		Degradation of the extracellular matrix Degradation of the extracellular matrix Defective B3GALTL causes PpS O-glycosylation of TSR domain-containing proteins	Metallothioneins bind metals Metallothioneins bind metals Interferon gamma signaling
Drugs		None	Zinc Silver Zinc acetate Zinc chloride Zinc sulfate, unspecified form
GWAS		Alzheimer's disease or family history of Alzheimer's disease ( 30617256 ) Asthma ( 27182965 31361310 31619474 ) Eosinophil count ( 32888494 ) Eosinophil percentage of white cells ( 32888494 ) Family history of Alzheimer's disease ( 30617256 ) HDL cholesterol levels ( 32203549 ) Monocyte percentage of white cells ( 27863252 32888494 )	No GWAS studies recorded
Interacting Genes		11 interacting genes: ACAN BCAN FN1 FURIN HP MT2A SERPINA1 SERPINA3 SRPX2 YTHDC1 ZBTB16	21 interacting genes: ADAMTS4 ARF6 ASS1 BARD1 DHODH ECT2 EOLA1 HMGB1 JMJD1C LAMTOR5 MCPH1 PAXIP1 PPDPF PRKD1 RCHY1 RIN3 SHBG SPINK7 TNS2 USP25 USP40
Entrez ID		9507	4502
HPRD ID		04853	08863
Ensembl ID		ENSG00000158859	ENSG00000125148
Uniprot IDs		O75173	P02795
PDB IDs		2RJP 3B2Z 4WK7 4WKE 4WKI	1MHU 2MHU
GO Terms Enriched among Interactors		Acute-phase Response Acute Inflammatory Response Extracellular Matrix Extracellular Space Extracellular Region Platelet Alpha Granule Lumen Perineuronal Net Serine-type Endopeptidase Inhibitor Activity Negative Regulation Of Transforming Growth Factor Beta Production Golgi Lumen Protease Binding Extracellular Matrix Structural Constituent Blood Microparticle Hyaluronic Acid Binding Central Nervous System Development Skeletal System Development Inflammatory Response Zymogen Activation Negative Regulation Of Nerve Growth Factor Production Dibasic Protein Processing Zymogen Inhibition Hepatocyte Growth Factor Binding Protein Maturation Negative Regulation Of Hydrogen Peroxide Catabolic Process Golgi Apparatus Subcompartment Regulation Of Nerve Growth Factor Production Negative Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Nerve Growth Factor Production Negative Regulation Of Neurotrophin Production Type 2 Angiotensin Receptor Binding Primary Follicle Stage Lysosomal Lumen Cell Adhesion Negative Regulation Of Monocyte Activation Positive Regulation Of Substrate-dependent Cell Migration, Cell Attachment To Substrate Negative Regulation Of Receptor Catabolic Process Male Germ-line Stem Cell Asymmetric Division Mammalian Oogenesis Stage Peptidase Inhibitor Activity Calcium-independent Cell-matrix Adhesion Cellular Response To Erythropoietin Viral Translation Viral Life Cycle Germ-line Stem Cell Division Positive Regulation Of NK T Cell Differentiation MRNA Alternative Polyadenylation System Development Hemoglobin Binding Response To Erythropoietin Cytokine Precursor Processing	Negative Regulation Of Endocytosis Positive Regulation Of Mitotic Cytokinetic Process Positive Regulation Of Mitotic Cytokinesis Regulation Of Mitotic Cytokinesis Negative Regulation Of Transport Regulation Of Cellular Component Size Positive Regulation Of Protein Localization To Nucleus Liver Development Regulation Of Establishment Of Protein Localization Regulation Of Cellular Localization Cellular Response To Stress Regulation Of Nucleocytoplasmic Transport Regulation Of Protein Localization Erythrocyte Apoptotic Process Positive Regulation Of Establishment Of Protein Localization Regulation Of Endocytosis Negative Regulation Of Receptor-mediated Endocytosis Argininosuccinate Synthase Activity Argininosuccinate Metabolic Process Regulation Of Intracellular Protein Transport Regulation Of Protein Export From Nucleus Response To Ionizing Radiation Negative Regulation Of MRNA 3'-end Processing Dihydroorotate Dehydrogenase Activity Dihydroorotate Dehydrogenase (quinone) Activity Regulation Of Cytokinesis, Actomyosin Contractile Ring Assembly Positive Regulation Of Protein Import Into Nucleus Regulation Of Protein Localization To Nucleus Calcium-dependent Protein Kinase Regulator Activity Regulation Of Restriction Endodeoxyribonuclease Activity Positive Regulation Of Myeloid Progenitor Cell Differentiation Regulation Of Skeletal Muscle Contraction By Modulation Of Calcium Ion Sensitivity Of Myofibril Negative Regulation Of Mast Cell Chemotaxis