BCAN and MMP7

Number of citations of the paper that reports this interaction (PubMedID 10986281)
0

Data Source:
BioGRID (enzymatic study)
HPRD (in vitro)

		BCAN	MMP7
Description		brevican	matrix metallopeptidase 7
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Golgi Lumen Membrane Extracellular Matrix Lysosomal Lumen Synapse Perineuronal Net Side Of Membrane Glutamatergic Synapse	Extracellular Region Extracellular Space Extracellular Matrix Extracellular Exosome
	Molecular Function	Protein Binding Hyaluronic Acid Binding Carbohydrate Binding	Endopeptidase Activity Metalloendopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity Metal Ion Binding
	Biological Process	Skeletal System Development Cell Adhesion Central Nervous System Development Hippocampus Development Synapse Maturation	Antibacterial Peptide Secretion Antibacterial Peptide Biosynthetic Process Proteolysis Membrane Protein Ectodomain Proteolysis Response To Xenobiotic Stimulus Extracellular Matrix Disassembly Extracellular Matrix Organization Positive Regulation Of Cell Migration Collagen Catabolic Process Membrane Protein Intracellular Domain Proteolysis Regulation Of Cell Population Proliferation Defense Response To Bacterium Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium
Pathways		Degradation of the extracellular matrix Glycosaminoglycan-protein linkage region biosynthesis CS-GAG biosynthesis DS-GAG biosynthesis CS/DS degradation ECM proteoglycans Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Defective CHST14 causes EDS, musculocontractural type Defective CHSY1 causes TPBS Defective B3GALT6 causes EDSP2 and SEMDJL1	Collagen degradation Degradation of the extracellular matrix Degradation of the extracellular matrix Activation of Matrix Metalloproteinases Assembly of collagen fibrils and other multimeric structures Extra-nuclear estrogen signaling
Drugs			Marimastat (1R)-N,6-DIHYDROXY-7-METHOXY-2-[(4-METHOXYPHENYL)SULFONYL]-1,2,3,4-TETRAHYDROISOQUINOLINE-1-CARBOXAMIDE N4-HYDROXY-2-ISOBUTYL-N1-(9-OXO-1,8-DIAZA-TRICYCLO[10.6.1.013,18]NONADECA-12(19),13,15,17-TETRAEN-10-YL)-SUCCINAMIDE 5-METHYL-3-(9-OXO-1,8-DIAZA-TRICYCLO[10.6.1.013,18]NONADECA-12(19),13,15,17-TETRAEN-10-YLCARBAMOYL)-HEXANOIC ACID
Diseases
GWAS		Blood protein levels ( 30072576)	Blood protein levels ( 30072576) Night sleep phenotypes ( 27126917) Prostate cancer ( 23535732) Prostate-specific antigen levels ( 28139693)
Interacting Genes		10 interacting genes: ADAMTS4 FBLN2 MMP1 MMP10 MMP13 MMP2 MMP3 MMP7 MMP8 TNR	16 interacting genes: BCAN CD151 CD44 DCN FASLG HAPLN1 HBEGF MBP MMP1 MMP9 NGF PLG SERPINA1 SPP1 TFPI TNFSF11
Entrez ID		63827	4316
HPRD ID		02644	01525
Ensembl ID		ENSG00000132692	ENSG00000137673
Uniprot IDs		Q96GW7	P09237
PDB IDs			1MMP 1MMQ 1MMR 2DDY 2MZE 2MZH 2MZI 2Y6C 2Y6D 5UE2 5UE5 7WXX 8JUD 8JUF 8JUG 8K4Z
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Disassembly Collagen Catabolic Process Metalloendopeptidase Activity Extracellular Matrix Extracellular Structure Organization Extracellular Matrix Organization Metallopeptidase Activity Collagen Metabolic Process Endopeptidase Activity Serine-type Endopeptidase Activity Peptidase Activity Extracellular Region Cellular Response To UV-A Proteolysis Response To UV-A Extracellular Space Hydrolase Activity Catabolic Process Zinc Ion Binding Response To Amyloid-beta Cellular Response To UV Protein Metabolic Process Cellular Response To Light Stimulus Response To UV Cellular Response To Radiation Metal Ion Binding Endodermal Cell Differentiation Regulation Of Neuroinflammatory Response Antibacterial Peptide Secretion Response To Light Stimulus Cellular Response To Amino Acid Stimulus Macromolecule Metabolic Process Negative Regulation Of Axon Extension Involved In Regeneration Response To Radiation Regulation Of Cell Migration Cellular Response To Reactive Oxygen Species Antibacterial Peptide Biosynthetic Process Axon Extension Involved In Regeneration Regulation Of Cell Motility Response To Amino Acid Cellular Response To Lipid Regulation Of Locomotion Positive Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Tenascin Complex Neuroblast Migration Ossification Intramembranous Ossification Blood Vessel Maturation Peripheral Nervous System Axon Regeneration Response To Reactive Oxygen Species	Extracellular Region Extracellular Space Extracellular Matrix Cell Surface Hyaluronic Acid Binding Wound Healing, Spreading Of Cells Extracellular Matrix Disassembly Regulation Of Response To Wounding Cellular Response To UV-A Perineuronal Net Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Multicellular Organismal Process Positive Regulation Of Lipid Transport Extracellular Matrix Structural Constituent Conferring Compression Resistance Positive Regulation Of Keratinocyte Migration Response To UV-A Positive Regulation Of Bone Resorption Lysosomal Lumen Positive Regulation Of Cell Communication Positive Regulation Of Signaling Endopeptidase Activity Regulation Of Cellular Component Organization Cell Migration Golgi Lumen Transmembrane Receptor Protein Tyrosine Kinase Activator Activity Coagulation Blood Coagulation Protease Binding Peptidase Inhibitor Activity Hemostasis Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Collateral Sprouting System Development Developmental Process Cell Motility Regulation Of Lipid Transport Regulation Of Wound Healing Positive Regulation Of Signal Transduction Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Cellular Component Organization Positive Regulation Of Intracellular Signal Transduction Tumor Necrosis Factor Receptor Binding Central Nervous System Development Extracellular Matrix Binding Serine-type Endopeptidase Activity Regulation Of Apoptotic Signaling Pathway Signaling Receptor Binding Positive Regulation Of ERBB Signaling Pathway Regulation Of Bone Resorption Collagen Catabolic Process
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