ADAMTS4 and SRPX2

Number of citations of the paper that reports this interaction (PMID 18718938)
10

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		ADAMTS4	SRPX2
Gene Name		ADAM metallopeptidase with thrombospondin type 1 motif, 4	sushi-repeat containing protein, X-linked 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Proteinaceous Extracellular Matrix Extracellular Space Extracellular Matrix	Extracellular Space Cytoplasm Cell Surface Cell Junction Excitatory Synapse Synaptic Membrane
	Molecular Function	Protease Binding Metalloendopeptidase Activity Protein Binding Peptidase Activity Metallopeptidase Activity Zinc Ion Binding	Receptor Binding Protein Binding Hepatocyte Growth Factor Binding Identical Protein Binding
	Biological Process	Skeletal System Development Proteolysis Extracellular Matrix Disassembly Extracellular Matrix Organization Defense Response To Bacterium	Angiogenesis Single Organismal Cell-cell Adhesion Regulation Of Phosphorylation Cell Motility Positive Regulation Of Synapse Assembly Vocalization Behavior Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis
Pathways		Post-translational protein modification O-glycosylation of TSR domain-containing proteins Degradation of the extracellular matrix O-linked glycosylation
Drugs
Diseases
GWAS
Protein-Protein Interactions		11 interactors: ACAN BCAN FN1 FURIN HP MT2A SERPINA1 SERPINA3 SRPX2 YTHDC1 ZBTB16	3 interactors: ADAMTS4 CTSB PLAUR
Entrez ID		9507	27286
HPRD ID		04853	06726
Ensembl ID			ENSG00000102359
Uniprot IDs		O75173	O60687
PDB IDs		2RJP 3B2Z
Enriched GO Terms of Interacting Partners?		Acute-phase Response Acute Inflammatory Response Extracellular Matrix Disassembly Extracellular Matrix Organization Extracellular Structure Organization Regulation Of Peptidase Activity Inflammatory Response Pathogenesis Regulation Of Proteolysis Defense Response Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Proteoglycan Biosynthetic Process Glycosaminoglycan Catabolic Process Negative Regulation Of Catalytic Activity Negative Regulation Of Proteolysis Platelet Degranulation Negative Regulation Of Hydrogen Peroxide Catabolic Process Negative Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Response To Methanol Negative Regulation Of Protein Processing Regulation Of Endopeptidase Activity Negative Regulation Of Hydrolase Activity Regulation Of Protein Processing Nerve Growth Factor Production Response To Triglyceride Glycosaminoglycan Biosynthetic Process Proteoglycan Metabolic Process Response To Inorganic Substance Negative Regulation Of Transforming Growth Factor Beta1 Production Negative Regulation Of Receptor Catabolic Process Secretion By Cell Cell Adhesion Negative Regulation Of Cellular Metabolic Process Response To Chromate Cellular Response To Erythropoietin Nerve Growth Factor Processing Calcium-independent Cell-matrix Adhesion Negative Regulation Of Hydrogen Peroxide Metabolic Process Skeletal System Development Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Cellular Response To Interleukin-3 Positive Regulation Of NK T Cell Differentiation Negative Regulation Of Transforming Growth Factor Beta Production Negative Regulation Of Serine-type Endopeptidase Activity Male Germ-line Stem Cell Asymmetric Division Secretion Regulation Of Catalytic Activity Glycosaminoglycan Metabolic Process Negative Regulation Of Serine-type Peptidase Activity	Extracellular Matrix Disassembly Urokinase Plasminogen Activator Signaling Pathway Extracellular Matrix Organization Extracellular Structure Organization Cellular Response To Thyroid Hormone Stimulus Attachment Of GPI Anchor To Protein Response To Thyroid Hormone Decidualization Response To Stress C-terminal Protein Lipidation Fibrinolysis Maternal Placenta Development
Tagcloud ?		affymetrix continues crabp2 depleted differentiating directs driving exons intergenic introns luciferase master mineralization networks occupancy osteoblast osteoblastogenesis osteoblasts osteogenesis partitioned peaks performing regions remodelers runx2 termination throughput tnfrsf19 turnover	agenesis anteriorly arx callosum dcx encompass encompasses filamin flna fronto genitalia gpr56 heterotopia lch lcha lchb lchd lissencephaly malformative mcd pachygyria perisylvian periventricular pnh polymicrogyria reln sbh tuba1a xq28
Tagcloud (Difference) ?		affymetrix continues crabp2 depleted differentiating directs driving exons intergenic introns luciferase master mineralization networks occupancy osteoblast osteoblastogenesis osteoblasts osteogenesis partitioned peaks performing regions remodelers runx2 termination throughput tnfrsf19 turnover	agenesis anteriorly arx callosum dcx encompass encompasses filamin flna fronto genitalia gpr56 heterotopia lch lcha lchb lchd lissencephaly malformative mcd pachygyria perisylvian periventricular pnh polymicrogyria reln sbh tuba1a xq28
Tagcloud (Intersection) ?