ADAMTS4 and SRPX2

Number of citations: 0 (PubMedID 18718938)
Data Source: HPRD (in vivo, two hybrid, in vitro)

		ADAMTS4	SRPX2
Name		ADAM metallopeptidase with thrombospondin type 1 motif 4	sushi repeat containing protein X-linked 2
Structure			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nuclear Speck Extracellular Matrix	Extracellular Region Extracellular Space Cytoplasm Cell Surface Extracellular Matrix Synapse Excitatory Synapse Synaptic Membrane Glutamatergic Synapse
	Molecular Function	Protease Binding Metalloendopeptidase Activity Protein Binding Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity Metal Ion Binding	Signaling Receptor Binding Extracellular Matrix Structural Constituent Protein Binding Hepatocyte Growth Factor Binding Identical Protein Binding
	Biological Process	Skeletal System Development Proteolysis Extracellular Matrix Disassembly Proteoglycan Catabolic Process Extracellular Matrix Organization Defense Response To Bacterium	Angiogenesis Cell Adhesion Regulation Of Phosphorylation Cell Motility Regulation Of Synapse Assembly Positive Regulation Of Synapse Assembly Vocalization Behavior Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Cell-cell Adhesion
Pathways		Degradation of the extracellular matrix Degradation of the extracellular matrix Defective B3GALTL causes PpS O-glycosylation of TSR domain-containing proteins	None
Diseases		None	Polymicrogyria; Bilateral frontal polymicrogyria (BFP); Bilateral frontoparietal polymicrogyria (BFPP); Bilateral perisylvian polymicrogyria (BPP); Bilateral parasagittal parieto-occipital polymicrogyria (BPOP); Bilateral generalised polymicrogyria (BGP); Unilateral Polymicrogyria (ULP)
GWAS		Alzheimer's disease or family history of Alzheimer's disease ( 30617256 ) Asthma ( 27182965 31361310 31619474 ) Eosinophil count ( 32888494 ) Eosinophil percentage of white cells ( 32888494 ) Family history of Alzheimer's disease ( 30617256 ) HDL cholesterol levels ( 32203549 ) Monocyte percentage of white cells ( 27863252 32888494 )	No GWAS studies recorded
Interacting Genes		11 interacting genes: ACAN BCAN FN1 FURIN HP MT2A SERPINA1 SERPINA3 SRPX2 YTHDC1 ZBTB16	3 interacting genes: ADAMTS4 CTSB PLAUR
Entrez ID		9507	27286
HPRD ID		04853	06726
Ensembl ID		ENSG00000158859	ENSG00000102359
Uniprot IDs		O75173	O60687
PDB IDs		2RJP 3B2Z 4WK7 4WKE 4WKI	Not available
GO Terms Enriched among Interactors		Acute-phase Response Acute Inflammatory Response Extracellular Matrix Extracellular Space Extracellular Region Platelet Alpha Granule Lumen Perineuronal Net Serine-type Endopeptidase Inhibitor Activity Negative Regulation Of Transforming Growth Factor Beta Production Golgi Lumen Protease Binding Extracellular Matrix Structural Constituent Blood Microparticle Hyaluronic Acid Binding Central Nervous System Development Skeletal System Development Inflammatory Response Zymogen Activation Negative Regulation Of Nerve Growth Factor Production Dibasic Protein Processing Zymogen Inhibition Hepatocyte Growth Factor Binding Protein Maturation Negative Regulation Of Hydrogen Peroxide Catabolic Process Golgi Apparatus Subcompartment Regulation Of Nerve Growth Factor Production Negative Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Nerve Growth Factor Production Negative Regulation Of Neurotrophin Production Type 2 Angiotensin Receptor Binding Primary Follicle Stage Lysosomal Lumen Cell Adhesion Negative Regulation Of Monocyte Activation Positive Regulation Of Substrate-dependent Cell Migration, Cell Attachment To Substrate Negative Regulation Of Receptor Catabolic Process Male Germ-line Stem Cell Asymmetric Division Mammalian Oogenesis Stage Peptidase Inhibitor Activity Calcium-independent Cell-matrix Adhesion Cellular Response To Erythropoietin Viral Translation Viral Life Cycle Germ-line Stem Cell Division Positive Regulation Of NK T Cell Differentiation MRNA Alternative Polyadenylation System Development Hemoglobin Binding Response To Erythropoietin Cytokine Precursor Processing	Thyroid Hormone Generation Extracellular Region Peptidase Activity External Side Of Plasma Membrane Endolysosome Lumen Peptidase Inhibitor Complex Proteoglycan Binding Extracellular Matrix Cellular Response To Thyroid Hormone Stimulus Serine-type Endopeptidase Complex Urokinase Plasminogen Activator Receptor Activity Protein Complex Involved In Cell-matrix Adhesion Urokinase Plasminogen Activator Signaling Pathway Proteoglycan Catabolic Process Thyroid Hormone Metabolic Process Response To Thyroid Hormone Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of DNA Binding Extrinsic Component Of Membrane Regulation Of Fibrinolysis Regulation Of Plasminogen Activation Decidualization Positive Regulation Of Release Of Cytochrome C From Mitochondria Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Glycoprotein Catabolic Process Positive Regulation Of ERBB Signaling Pathway