BCAN and MMP10

Number of citations of the paper that reports this interaction (PMID 10986281)
28

Data Source:
HPRD (in vitro)

		BCAN	MMP10
Gene Name		brevican	matrix metallopeptidase 10 (stromelysin 2)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Proteinaceous Extracellular Matrix Golgi Lumen Anchored Component Of Membrane Lysosomal Lumen	Extracellular Region Proteinaceous Extracellular Matrix Extracellular Space
	Molecular Function	Extracellular Matrix Structural Constituent Hyaluronic Acid Binding Carbohydrate Binding	Metalloendopeptidase Activity Calcium Ion Binding Zinc Ion Binding
	Biological Process	Skeletal System Development Carbohydrate Metabolic Process Cell Adhesion Central Nervous System Development Pathogenesis Hippocampus Development Extracellular Matrix Disassembly Extracellular Matrix Organization Glycosaminoglycan Metabolic Process Chondroitin Sulfate Metabolic Process Chondroitin Sulfate Biosynthetic Process Chondroitin Sulfate Catabolic Process Dermatan Sulfate Biosynthetic Process Small Molecule Metabolic Process	Proteolysis Extracellular Matrix Disassembly Extracellular Matrix Organization Regulation Of Cell Migration Collagen Catabolic Process
Pathways		MPS IIIB - Sanfilippo syndrome B Diseases of glycosylation Heparan sulfate/heparin (HS-GAG) metabolism Defective B4GALT7 causes EDS, progeroid type MPS I - Hurler syndrome MPS IX - Natowicz syndrome Chondroitin sulfate/dermatan sulfate metabolism CS/DS degradation Defective SLC26A2 causes chondrodysplasias Glycosaminoglycan metabolism Degradation of the extracellular matrix Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective CHST14 causes EDS, musculocontractural type Defective PAPSS2 causes SEMD-PA MPS IIIA - Sanfilippo syndrome A Myoclonic epilepsy of Lafora ECM proteoglycans Defective CHST6 causes MCDC1 Glycogen storage diseases MPS IIID - Sanfilippo syndrome D A tetrasaccharide linker sequence is required for GAG synthesis Chondroitin sulfate biosynthesis MPS IIIC - Sanfilippo syndrome C Diseases associated with glycosaminoglycan metabolism Mucopolysaccharidoses Defective EXT2 causes exostoses 2 MPS II - Hunter syndrome Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Defective EXT1 causes exostoses 1, TRPS2 and CHDS MPS IV - Morquio syndrome A Dermatan sulfate biosynthesis MPS IV - Morquio syndrome B Defective CHSY1 causes TPBS MPS VII - Sly syndrome Metabolism of carbohydrates MPS VI - Maroteaux-Lamy syndrome	Collagen degradation Activation of Matrix Metalloproteinases Degradation of the extracellular matrix
Drugs
Diseases
GWAS			Multiple sclerosis ( 23412934) Prostate cancer ( 23535732)
Protein-Protein Interactions		10 interactors: ADAMTS4 FBLN2 MMP1 MMP10 MMP13 MMP2 MMP3 MMP7 MMP8 TNR	3 interactors: BCAN HAPLN1 MMP9
Entrez ID		63827	4319
HPRD ID		02644	01704
Ensembl ID		ENSG00000132692	ENSG00000166670
Uniprot IDs		Q96GW7	P09238
PDB IDs			1Q3A 3V96
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Organization Extracellular Structure Organization Extracellular Matrix Disassembly Collagen Catabolic Process Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Proteolysis Catabolic Process Positive Regulation Of Protein Oligomerization Regulation Of Protein Oligomerization Endodermal Cell Differentiation Endoderm Formation Protein Metabolic Process Cellular Response To Amino Acid Stimulus Antibacterial Peptide Secretion Antibacterial Peptide Biosynthetic Process Negative Regulation Of Axon Extension Involved In Regeneration Endoderm Development Response To Amino Acid Formation Of Primary Germ Layer Skeletal System Development Negative Regulation Of Hydrogen Peroxide Metabolic Process Positive Regulation Of Protein Complex Assembly Cellular Response To Acid Chemical Gastrulation Defense Response To Bacterium Positive Regulation Of Transmission Of Nerve Impulse Negative Regulation Of Axon Regeneration Positive Regulation Of Oxidative Stress-induced Cell Death Intramembranous Ossification Regulation Of Hydrogen Peroxide Metabolic Process Bone Trabecula Formation Response To External Stimulus Regulation Of Transmission Of Nerve Impulse Locomotory Exploration Behavior Blood Vessel Maturation Skeletal System Morphogenesis Cellular Response To Nitric Oxide Ossification Neuron Cell-cell Adhesion Response To Nitric Oxide Positive Regulation Of Cellular Component Biogenesis Bone Trabecula Morphogenesis Regulation Of Axon Regeneration Regulation Of Protein Complex Assembly Growth Plate Cartilage Development Response To Stress Positive Regulation Of Synaptic Transmission, Glutamatergic Cellular Response To Reactive Nitrogen Species	Extracellular Matrix Organization Extracellular Structure Organization Skeletal System Development Extracellular Matrix Disassembly Positive Regulation Of Receptor Binding Positive Regulation Of Keratinocyte Migration Nervous System Development Dermatan Sulfate Biosynthetic Process Dermatan Sulfate Proteoglycan Biosynthetic Process Dermatan Sulfate Proteoglycan Metabolic Process Chondroitin Sulfate Catabolic Process Negative Regulation Of Cation Channel Activity Macrophage Differentiation Chondroitin Sulfate Biosynthetic Process Chondroitin Sulfate Proteoglycan Biosynthetic Process Endodermal Cell Differentiation Central Nervous System Development Negative Regulation Of Transporter Activity System Development Negative Regulation Of Ion Transmembrane Transport Negative Regulation Of Transmembrane Transport Endoderm Formation Proteoglycan Biosynthetic Process Glycosaminoglycan Catabolic Process Cell Adhesion Chondroitin Sulfate Metabolic Process Collagen Catabolic Process Multicellular Organismal Development Positive Regulation Of Protein Binding Hippocampus Development Anatomical Structure Development Regulation Of Cation Channel Activity Embryo Implantation Collagen Metabolic Process Positive Regulation Of Epithelial Cell Migration Multicellular Organismal Macromolecule Metabolic Process Endoderm Development Multicellular Organismal Metabolic Process Negative Regulation Of Ion Transport Limbic System Development Ephrin Receptor Signaling Pathway Glycosaminoglycan Biosynthetic Process Developmental Process Proteoglycan Metabolic Process Myeloid Leukocyte Differentiation Positive Regulation Of Binding Catabolic Process Formation Of Primary Germ Layer Regulation Of Ion Transmembrane Transporter Activity Regulation Of Epithelial Cell Migration
Tagcloud ?		abundant astrocytes basic cg clustering differentiated diverse embryos enriched fbln2 forebrain foundation functionally glial itih3 mesenchymal ncam1 nervous networks neural nsc nscs ontology regulators rich tnr transcriptomes vcan wnt	affecting bad biochemical blotting cadherin compartments concomitant conveys cxcr4 delay elisa extracellular herein invasion jnk matrix mcf7 mek obtain overexpressing ras reporter semi sirna snail sp1 stats tlmp2 valuable
Tagcloud (Difference) ?		abundant astrocytes basic cg clustering differentiated diverse embryos enriched fbln2 forebrain foundation functionally glial itih3 mesenchymal ncam1 nervous networks neural nsc nscs ontology regulators rich tnr transcriptomes vcan wnt	affecting bad biochemical blotting cadherin compartments concomitant conveys cxcr4 delay elisa extracellular herein invasion jnk matrix mcf7 mek obtain overexpressing ras reporter semi sirna snail sp1 stats tlmp2 valuable
Tagcloud (Intersection) ?