BCAN and MMP10

Number of citations of the paper that reports this interaction (PubMedID 10986281)
0

Data Source:
HPRD (in vitro)

		BCAN	MMP10
Description		brevican	matrix metallopeptidase 10
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Golgi Lumen Membrane Extracellular Matrix Lysosomal Lumen Synapse Perineuronal Net Side Of Membrane Glutamatergic Synapse	Extracellular Region Extracellular Space Extracellular Matrix
	Molecular Function	Protein Binding Hyaluronic Acid Binding Carbohydrate Binding	Endopeptidase Activity Metalloendopeptidase Activity Serine-type Endopeptidase Activity Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity Metal Ion Binding
	Biological Process	Skeletal System Development Cell Adhesion Central Nervous System Development Hippocampus Development Synapse Maturation	Proteolysis Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process
Pathways		Degradation of the extracellular matrix Glycosaminoglycan-protein linkage region biosynthesis CS-GAG biosynthesis DS-GAG biosynthesis CS/DS degradation ECM proteoglycans Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Defective CHST14 causes EDS, musculocontractural type Defective CHSY1 causes TPBS Defective B3GALT6 causes EDSP2 and SEMDJL1	Collagen degradation Collagen degradation Degradation of the extracellular matrix Degradation of the extracellular matrix Activation of Matrix Metalloproteinases
Drugs			Marimastat N-ISOBUTYL-N-[4-METHOXYPHENYLSULFONYL]GLYCYL HYDROXAMIC ACID
Diseases
GWAS		Blood protein levels ( 30072576)	Blood protein levels ( 30072576) Multiple sclerosis ( 23412934) Prostate cancer ( 23535732)
Interacting Genes		10 interacting genes: ADAMTS4 FBLN2 MMP1 MMP10 MMP13 MMP2 MMP3 MMP7 MMP8 TNR	3 interacting genes: BCAN HAPLN1 MMP9
Entrez ID		63827	4319
HPRD ID		02644	01704
Ensembl ID		ENSG00000132692	ENSG00000166670
Uniprot IDs		Q96GW7	P09238
PDB IDs			1Q3A 3V96 4ILW
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Disassembly Collagen Catabolic Process Metalloendopeptidase Activity Extracellular Matrix Extracellular Structure Organization Extracellular Matrix Organization Metallopeptidase Activity Collagen Metabolic Process Endopeptidase Activity Serine-type Endopeptidase Activity Peptidase Activity Extracellular Region Cellular Response To UV-A Proteolysis Response To UV-A Extracellular Space Hydrolase Activity Catabolic Process Zinc Ion Binding Response To Amyloid-beta Cellular Response To UV Protein Metabolic Process Cellular Response To Light Stimulus Response To UV Cellular Response To Radiation Metal Ion Binding Endodermal Cell Differentiation Regulation Of Neuroinflammatory Response Antibacterial Peptide Secretion Response To Light Stimulus Cellular Response To Amino Acid Stimulus Macromolecule Metabolic Process Negative Regulation Of Axon Extension Involved In Regeneration Response To Radiation Regulation Of Cell Migration Cellular Response To Reactive Oxygen Species Antibacterial Peptide Biosynthetic Process Axon Extension Involved In Regeneration Regulation Of Cell Motility Response To Amino Acid Cellular Response To Lipid Regulation Of Locomotion Positive Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Tenascin Complex Neuroblast Migration Ossification Intramembranous Ossification Blood Vessel Maturation Peripheral Nervous System Axon Regeneration Response To Reactive Oxygen Species	Perineuronal Net Central Nervous System Development Skeletal System Development Hyaluronic Acid Binding System Development Positive Regulation Of Release Of Cytochrome C From Mitochondria Regulation Of Release Of Cytochrome C From Mitochondria Extracellular Matrix Cellular Response To UV Cellular Response To Light Stimulus Negative Regulation Of Helicase Activity Negative Regulation Of G1 To G0 Transition Regulation Of Mitochondrion Organization Response To UV Cellular Response To Radiation Regulation Of Intrinsic Apoptotic Signaling Pathway Oligodendrocyte Apoptotic Process Negative Regulation Of Fermentation Intrinsic Apoptotic Signaling Pathway In Response To Hypoxia Negative Regulation Of Pentose-phosphate Shunt Oxidative Stress-induced Premature Senescence Negative Regulation Of Glucose Catabolic Process To Lactate Via Pyruvate Glucose Catabolic Process To Lactate Via Pyruvate Germ Cell Nucleus Cellular Response To Actinomycin D Negative Regulation Of Epithelial Cell Differentiation Involved In Kidney Development Positive Regulation Of Thymocyte Apoptotic Process Response To Actinomycin D T Cell Proliferation Involved In Immune Response Histone Deacetylase Regulator Activity Positive Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly Regulation Of G1 To G0 Transition Glial Cell Apoptotic Process Cellular Response To UV-C ATP-dependent DNA/DNA Annealing Activity B Cell Lineage Commitment Regulation Of Pentose-phosphate Shunt Mitochondrial DNA Repair Bone Marrow Development Stress-induced Premature Senescence Regulation Of NADP Metabolic Process Negative Regulation Of MiRNA Processing Mononuclear Cell Differentiation Response To Light Stimulus Cellular Response To UV-A Extracellular Space TFIID-class Transcription Factor Complex Binding Positive Regulation Of Programmed Necrotic Cell Death Cellular Response To Antibiotic Extracellular Matrix Structural Constituent Conferring Compression Resistance
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