BCAN and MMP8

Number of citations of the paper that reports this interaction (PubMedID 10986281)
0

Data Source:
HPRD (in vitro)

		BCAN	MMP8
Description		brevican	matrix metallopeptidase 8
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Golgi Lumen Membrane Extracellular Matrix Lysosomal Lumen Synapse Perineuronal Net Side Of Membrane Glutamatergic Synapse	Extracellular Region Extracellular Space Extracellular Matrix Specific Granule Lumen Tertiary Granule Lumen
	Molecular Function	Protein Binding Hyaluronic Acid Binding Carbohydrate Binding	Endopeptidase Activity Metalloendopeptidase Activity Serine-type Endopeptidase Activity Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity Tumor Necrosis Factor Binding Metal Ion Binding
	Biological Process	Skeletal System Development Cell Adhesion Central Nervous System Development Hippocampus Development Synapse Maturation	Proteolysis Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process Positive Regulation Of Tumor Necrosis Factor Production Endodermal Cell Differentiation Cellular Response To Lipopolysaccharide Positive Regulation Of Neuroinflammatory Response Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Microglial Cell Activation
Pathways		Degradation of the extracellular matrix Glycosaminoglycan-protein linkage region biosynthesis CS-GAG biosynthesis DS-GAG biosynthesis CS/DS degradation ECM proteoglycans Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Defective CHST14 causes EDS, musculocontractural type Defective CHSY1 causes TPBS Defective B3GALT6 causes EDSP2 and SEMDJL1	Collagen degradation Degradation of the extracellular matrix Activation of Matrix Metalloproteinases Neutrophil degranulation
Drugs			Marimastat 1-Hydroxyamine-2-Isobutylmalonic Acid 2-Thiomethyl-3-Phenylpropanoic Acid 2-(Biphenyl-4-Sulfonyl)-1,2,3,4-Tetrahydro-Isoquinoline-3-Carboxylic Acid 5-[4-(2-Hydroxyethyl)-1-piperidinyl]-5-phenyl-2,4,6(1H,3H,5H)-pyrimidinetrione Glycinamide Batimastat N-{2-[(4'-CYANO-1,1'-BIPHENYL-4-YL)OXY]ETHYL}-N'-HYDROXY-N-METHYLUREA (5S)-5-(2-amino-2-oxoethyl)-4-oxo-N-[(3-oxo-3,4-dihydro-2H-1,4-benzoxazin-6-yl)methyl]-3,4,5,6,7,8-hexahydro[1]benzothieno[2,3-d]pyrimidine-2-carboxamide (1S)-1-{[(4'-methoxy-1,1'-biphenyl-4-yl)sulfonyl]amino}-2-methylpropylphosphonic acid (1R)-1-{[(4'-methoxy-1,1'-biphenyl-4-yl)sulfonyl]amino}-2-methylpropylphosphonic acid 3-FORMYL-2-HYDROXY-5-METHYL-HEXANOIC ACID HYDROXYAMIDE BUT-3-ENYL-[5-(4-CHLORO-PHENYL)-3,6-DIHYDRO-[1,3,4]THIADIAZIN-2-YLIDENE]-AMINE METHYLAMINO-PHENYLALANYL-LEUCYL-HYDROXAMIC ACID 3-AMINO-AZACYCLOTRIDECAN-2-ONE
Diseases
GWAS		Blood protein levels ( 30072576)	Blood protein levels ( 30072576) Epilepsy ( 25087078) Prostate cancer ( 23535732)
Interacting Genes		10 interacting genes: ADAMTS4 FBLN2 MMP1 MMP10 MMP13 MMP2 MMP3 MMP7 MMP8 TNR	7 interacting genes: ACAN BCAN CCL2 FBXO7 TFPI TIMP2 UMOD
Entrez ID		63827	4317
HPRD ID		02644	00385
Ensembl ID		ENSG00000132692	ENSG00000118113
Uniprot IDs		Q96GW7	B4E0I2 P22894
PDB IDs			1A85 1A86 1BZS 1I73 1I76 1JAN 1JAO 1JAP 1JAQ 1JH1 1JJ9 1KBC 1MMB 1MNC 1ZP5 1ZS0 1ZVX 2OY2 2OY4 3DNG 3DPE 3DPF 3TT4 4QKZ 5H8X
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Disassembly Collagen Catabolic Process Metalloendopeptidase Activity Extracellular Matrix Extracellular Structure Organization Extracellular Matrix Organization Metallopeptidase Activity Collagen Metabolic Process Endopeptidase Activity Serine-type Endopeptidase Activity Peptidase Activity Extracellular Region Cellular Response To UV-A Proteolysis Response To UV-A Extracellular Space Hydrolase Activity Catabolic Process Zinc Ion Binding Response To Amyloid-beta Cellular Response To UV Protein Metabolic Process Cellular Response To Light Stimulus Response To UV Cellular Response To Radiation Metal Ion Binding Endodermal Cell Differentiation Regulation Of Neuroinflammatory Response Antibacterial Peptide Secretion Response To Light Stimulus Cellular Response To Amino Acid Stimulus Macromolecule Metabolic Process Negative Regulation Of Axon Extension Involved In Regeneration Response To Radiation Regulation Of Cell Migration Cellular Response To Reactive Oxygen Species Antibacterial Peptide Biosynthetic Process Axon Extension Involved In Regeneration Regulation Of Cell Motility Response To Amino Acid Cellular Response To Lipid Regulation Of Locomotion Positive Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Tenascin Complex Neuroblast Migration Ossification Intramembranous Ossification Blood Vessel Maturation Peripheral Nervous System Axon Regeneration Response To Reactive Oxygen Species	Golgi Lumen Perineuronal Net Extracellular Space Side Of Membrane Extracellular Region Hyaluronic Acid Binding Cell Adhesion Helper T Cell Extravasation Negative Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Chemokine (C-C Motif) Ligand 2 Signaling Pathway Citric Acid Secretion Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Extracellular Matrix Lysosomal Lumen Granulocyte Migration Negative Regulation Of Natural Killer Cell Chemotaxis Negative Regulation Of Metallopeptidase Activity Metanephric Thick Ascending Limb Development Protein Transport Into Plasma Membrane Raft Micturition Peptidase Inhibitor Activity Negative Regulation Of Lymphocyte Chemotaxis Myeloid Leukocyte Migration Regulation Of Metallopeptidase Activity Juxtaglomerular Apparatus Development Renal Urate Salt Excretion Lewy Body Core Central Nervous System Development CCR2 Chemokine Receptor Binding Response To Water Deprivation Metanephric Ascending Thin Limb Development Protein Transport Into Membrane Raft Metanephric Distal Convoluted Tubule Development Negative Regulation Of Mitotic Cell Cycle Phase Transition T Cell Extravasation Negative Regulation Of Neuron Apoptotic Process Regulation Of G1/S Transition Of Mitotic Cell Cycle Protein Localization To Plasma Membrane Raft Tricarboxylic Acid Transport Loop Of Henle Development Citrate Transport Carbohydrate Binding Regulation Of Cell Cycle G1/S Phase Transition Skeletal System Development Astrocyte Cell Migration Negative Regulation Of Membrane Protein Ectodomain Proteolysis
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?