BCAN and TNR

Number of citations of the paper that reports this interaction (PMID 9294172)
27

Data Source:
HPRD (in vitro)

		BCAN	TNR
Gene Name		brevican	tenascin R
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Proteinaceous Extracellular Matrix Golgi Lumen Anchored Component Of Membrane Lysosomal Lumen	Extracellular Region Proteinaceous Extracellular Matrix Nucleus Nucleoplasm Cytoplasm Cell Surface Membrane Raft Perineuronal Net
	Molecular Function	Extracellular Matrix Structural Constituent Hyaluronic Acid Binding Carbohydrate Binding
	Biological Process	Skeletal System Development Carbohydrate Metabolic Process Cell Adhesion Central Nervous System Development Pathogenesis Hippocampus Development Extracellular Matrix Disassembly Extracellular Matrix Organization Glycosaminoglycan Metabolic Process Chondroitin Sulfate Metabolic Process Chondroitin Sulfate Biosynthetic Process Chondroitin Sulfate Catabolic Process Dermatan Sulfate Biosynthetic Process Small Molecule Metabolic Process	Cell Adhesion Neuron Cell-cell Adhesion Axon Guidance Associative Learning Telencephalon Cell Migration Negative Regulation Of Cell-cell Adhesion Extracellular Matrix Organization Locomotory Exploration Behavior Negative Regulation Of Axon Extension Involved In Regeneration Negative Regulation Of Synaptic Transmission Synapse Organization Neuromuscular Process Controlling Balance Positive Regulation Of Synaptic Transmission, Glutamatergic Positive Regulation Of Transmission Of Nerve Impulse Long-term Synaptic Potentiation
Pathways		MPS IIIB - Sanfilippo syndrome B Diseases of glycosylation Heparan sulfate/heparin (HS-GAG) metabolism Defective B4GALT7 causes EDS, progeroid type MPS I - Hurler syndrome MPS IX - Natowicz syndrome Chondroitin sulfate/dermatan sulfate metabolism CS/DS degradation Defective SLC26A2 causes chondrodysplasias Glycosaminoglycan metabolism Degradation of the extracellular matrix Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective CHST14 causes EDS, musculocontractural type Defective PAPSS2 causes SEMD-PA MPS IIIA - Sanfilippo syndrome A Myoclonic epilepsy of Lafora ECM proteoglycans Defective CHST6 causes MCDC1 Glycogen storage diseases MPS IIID - Sanfilippo syndrome D A tetrasaccharide linker sequence is required for GAG synthesis Chondroitin sulfate biosynthesis MPS IIIC - Sanfilippo syndrome C Diseases associated with glycosaminoglycan metabolism Mucopolysaccharidoses Defective EXT2 causes exostoses 2 MPS II - Hunter syndrome Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Defective EXT1 causes exostoses 1, TRPS2 and CHDS MPS IV - Morquio syndrome A Dermatan sulfate biosynthesis MPS IV - Morquio syndrome B Defective CHSY1 causes TPBS MPS VII - Sly syndrome Metabolism of carbohydrates MPS VI - Maroteaux-Lamy syndrome	ECM proteoglycans
Drugs
Diseases
GWAS			Tonometry ( 17903302)
Protein-Protein Interactions		10 interactors: ADAMTS4 FBLN2 MMP1 MMP10 MMP13 MMP2 MMP3 MMP7 MMP8 TNR	15 interactors: ACAN BCAN CCDC146 CNTN1 LGALS14 MAGEB4 NCAN NCK2 NFASC POLR3C PSMA1 PTPRZ1 SIGLEC1 VCAN WDYHV1
Entrez ID		63827	7143
HPRD ID		02644	03589
Ensembl ID		ENSG00000132692	ENSG00000116147
Uniprot IDs		Q96GW7	A1L306 Q92752
PDB IDs
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Organization Extracellular Structure Organization Extracellular Matrix Disassembly Collagen Catabolic Process Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Proteolysis Catabolic Process Positive Regulation Of Protein Oligomerization Regulation Of Protein Oligomerization Endodermal Cell Differentiation Endoderm Formation Protein Metabolic Process Cellular Response To Amino Acid Stimulus Antibacterial Peptide Secretion Antibacterial Peptide Biosynthetic Process Negative Regulation Of Axon Extension Involved In Regeneration Endoderm Development Response To Amino Acid Formation Of Primary Germ Layer Skeletal System Development Negative Regulation Of Hydrogen Peroxide Metabolic Process Positive Regulation Of Protein Complex Assembly Cellular Response To Acid Chemical Gastrulation Defense Response To Bacterium Positive Regulation Of Transmission Of Nerve Impulse Negative Regulation Of Axon Regeneration Positive Regulation Of Oxidative Stress-induced Cell Death Intramembranous Ossification Regulation Of Hydrogen Peroxide Metabolic Process Bone Trabecula Formation Response To External Stimulus Regulation Of Transmission Of Nerve Impulse Locomotory Exploration Behavior Blood Vessel Maturation Skeletal System Morphogenesis Cellular Response To Nitric Oxide Ossification Neuron Cell-cell Adhesion Response To Nitric Oxide Positive Regulation Of Cellular Component Biogenesis Bone Trabecula Morphogenesis Regulation Of Axon Regeneration Regulation Of Protein Complex Assembly Growth Plate Cartilage Development Response To Stress Positive Regulation Of Synaptic Transmission, Glutamatergic Cellular Response To Reactive Nitrogen Species	Proteoglycan Biosynthetic Process Glycosaminoglycan Catabolic Process Dermatan Sulfate Biosynthetic Process Cell Adhesion Dermatan Sulfate Proteoglycan Biosynthetic Process Dermatan Sulfate Proteoglycan Metabolic Process Chondroitin Sulfate Catabolic Process Glycosaminoglycan Biosynthetic Process Chondroitin Sulfate Biosynthetic Process Proteoglycan Metabolic Process Chondroitin Sulfate Proteoglycan Biosynthetic Process Glycosaminoglycan Metabolic Process Pathogenesis Chondroitin Sulfate Metabolic Process Axonogenesis Nervous System Development Central Nervous System Development Axon Development Cell Morphogenesis Involved In Neuron Differentiation Neuron Projection Morphogenesis Cell Morphogenesis Involved In Differentiation Sulfur Compound Metabolic Process Extracellular Matrix Organization Extracellular Structure Organization Axon Guidance Glycoprotein Biosynthetic Process Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis Glycoprotein Metabolic Process Neuron Development Neurogenesis Cell Morphogenesis Skeletal System Development Cell Development Neuron Differentiation Chemotaxis Cell Projection Organization Locomotion System Development Movement Of Cell Or Subcellular Component Cell Differentiation Generation Of Neurons Anatomical Structure Morphogenesis Regulation Of Endoplasmic Reticulum Stress-induced EIF2 Alpha Phosphorylation Multicellular Organismal Development Extracellular Matrix Disassembly Anatomical Structure Development Catabolic Process Carbohydrate Metabolic Process
Tagcloud ?		abundant astrocytes basic cg clustering differentiated diverse embryos enriched fbln2 forebrain foundation functionally glial itih3 mesenchymal ncam1 nervous networks neural nsc nscs ontology regulators rich tnr transcriptomes vcan wnt	1d4 achieve antagonists block comparing configuration cytotoxicity equimolar express fusion igg kym lt molar monomeric murine p55 p75 recombinant requiring rhabdomyosarcoma sf2 soluble subline tnf trimeric useful usual
Tagcloud (Difference) ?		abundant astrocytes basic cg clustering differentiated diverse embryos enriched fbln2 forebrain foundation functionally glial itih3 mesenchymal ncam1 nervous networks neural nsc nscs ontology regulators rich transcriptomes vcan wnt	1d4 achieve antagonists block comparing configuration cytotoxicity equimolar express fusion igg kym lt molar monomeric murine p55 p75 recombinant requiring rhabdomyosarcoma sf2 soluble subline tnf trimeric useful usual
Tagcloud (Intersection) ?		tnr