ATG16L1 and GAN

Number of citations of the paper that reports this interaction (PubMedID 30770803)
48

Data Source:
BioGRID (protein complementation assay)

		ATG16L1	GAN
Description		autophagy related 16 like 1	gigaxonin
Image
GO Annotations	Cellular Component	Autophagosome Membrane Cytoplasm Lysosome Lysosomal Membrane Endosome Autophagosome Cytosol Axoneme Endosome Membrane Membrane Axon Phagophore Assembly Site Membrane Atg12-Atg5-Atg16 Complex Endolysosome Membrane Synapse Sperm Midpiece Glutamatergic Synapse Vacuole-isolation Membrane Contact Site	Cytoplasm Cytosol Cytoskeleton Cul3-RING Ubiquitin Ligase Complex
	Molecular Function	Protein Binding Ubiquitin-like Protein Transferase Activity Identical Protein Binding Protein-membrane Adaptor Activity GTPase Binding	Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	Autophagosome Assembly C-terminal Protein Lipidation Autophagy Positive Regulation Of Autophagy Protein Transport Macroautophagy Microautophagy Hippocampus Development Corpus Callosum Development Protein Localization To Phagophore Assembly Site Negative Stranded Viral RNA Replication Defense Response To Virus Xenophagy Axonal Transport Dendrite Arborization Negative Regulation Of Dendrite Extension	Cytoskeleton Organization Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Pathways		Macroautophagy	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases		Crohn's disease
GWAS		Bilirubin levels ( 31319653 31801373 32084209) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 17435756 17554300 18587394 20570966 21102463 22412388 22936669 23128233 28067908) Inflammatory bowel disease ( 28067908) Pediatric autoimmune diseases ( 26301688) Serum alkaline phosphatase levels ( 33547301)	Age-related cataracts ( 25352737) Health literacy ( 31250787) Post bronchodilator FEV1 ( 26634245) Skin and soft tissue infections ( 33662382) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		20 interacting genes: APP ATG5 C3 CRYAA CSNK2A1 CSNK2A2 DEDD2 GAN IFT20 NLRP6 NOD1 NOD2 OPTN RAB33A RAB33B RIPK2 SETD7 TRAF3IP3 WIPI2 ZFP36	4 interacting genes: ATG16L1 MAP1B TBCB UBA1
Entrez ID		55054	8139
HPRD ID		16498	05647
Ensembl ID		ENSG00000085978	ENSG00000261609
Uniprot IDs		E7EVC7 Q17RG0 Q676U5	A0A0S2Z4W2 B3KTC3 Q9H2C0
PDB IDs		4GDK 4GDL 4NAW 4TQ0 5D7G 5NPV 5NPW 5NUV 5ZYX 7F69 7MU2 7W36 7XFR 8ZQG	2PPI 3HVE
Enriched GO Terms of Interacting Partners?		Autophagy Regulation Of Macroautophagy Response To Stress Positive Regulation Of Interleukin-1 Beta Production Regulation Of Autophagy Positive Regulation Of Catabolic Process Positive Regulation Of Interleukin-1 Production Regulation Of Cytokine Production Regulation Of Defense Response Macroautophagy Regulation Of Innate Immune Response Positive Regulation Of Defense Response Positive Regulation Of Autophagy Positive Regulation Of Xenophagy Cell Death Regulation Of Interleukin-1 Beta Production Positive Regulation Of Macroautophagy Cellular Response To Muramyl Dipeptide Protein-containing Complex Regulation Of Interleukin-1 Production Response To Bacterium Intracellular Signal Transduction CARD Domain Binding Signal Transduction Innate Immune Response Immune System Process Programmed Cell Death Regulation Of Immune Response Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of Stress-activated MAPK Cascade Defense Response To Bacterium Response To Muramyl Dipeptide Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Cytokine Production Golgi Apparatus Phagophore Assembly Site Membrane Defense Response To Symbiont Defense Response To Other Organism P38MAPK Cascade Protein Kinase CK2 Complex Protein Localization To Golgi Apparatus Regulation Of Apoptotic Process Autophagosome Assembly Positive Regulation Of Interleukin-6 Production Regulation Of Programmed Cell Death Positive Regulation Of JNK Cascade Negative Regulation Of Canonical NF-kappaB Signal Transduction Cytoplasmic Pattern Recognition Receptor Signaling Pathway Autophagosome Organization Immune Response	Induction Of Synaptic Plasticity By Chemical Substance Vacuole-isolation Membrane Contact Site Post-chaperonin Tubulin Folding Pathway Tubulin Complex Assembly Microtubule-based Process Cytosol Autophagy Plasmacytoid Dendritic Cell Activation Plasmacytoid Dendritic Cell Differentiation Follicular B Cell Differentiation Germinal Center B Cell Differentiation Positive Regulation Of Synaptic Plasticity Varicosity Cell Projection Morphogenesis Response To Insecticide Peripheral Nervous System Axon Regeneration Microtubule-based Transport Odontoblast Differentiation Transport Along Microtubule Neuron Projection Morphogenesis Hippocampal Mossy Fiber Cytoskeleton-dependent Intracellular Transport Basal Dendrite Endosome Membrane Rough Endoplasmic Reticulum Membrane Ubiquitin-like Modifier Activating Enzyme Activity Ubiquitin Activating Enzyme Activity C-terminal Protein Lipidation Viral RNA Genome Replication Xenophagy Negative Regulation Of Dendrite Extension Negative Stranded Viral RNA Replication Atg12-Atg5-Atg16 Complex Regulation Of Developmental Growth Dendrite Arborization Microtubule Response To Vitamin A Response To Stress Apical Dendrite Somatodendritic Compartment Microtubule-based Movement Lysosomal Membrane Protein Localization To Phagophore Assembly Site Regulation Of Cell Growth Axon Corpus Callosum Development Endolysosome Membrane Ubiquitin-like Protein Transferase Activity Neuron Projection Arborization Viral Genome Replication
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