ATG16L1 and NOD2

Number of citations of the paper that reports this interaction (PubMedID 27273576)
64

Data Source:
BioGRID (pull down)

		ATG16L1	NOD2
Description		autophagy related 16 like 1	nucleotide binding oligomerization domain containing 2
Image			No pdb structure
GO Annotations	Cellular Component	Autophagosome Membrane Cytoplasm Lysosome Lysosomal Membrane Endosome Autophagosome Cytosol Axoneme Endosome Membrane Membrane Axon Phagophore Assembly Site Membrane Atg12-Atg5-Atg16 Complex Endolysosome Membrane Synapse Sperm Midpiece Glutamatergic Synapse Vacuole-isolation Membrane Contact Site	Cytoplasm Mitochondrion Golgi Apparatus Cytosol Cytoskeleton Plasma Membrane Cell Surface Membrane Basolateral Plasma Membrane Extrinsic Component Of Plasma Membrane Vesicle Protein-containing Complex Phagocytic Vesicle
	Molecular Function	Protein Binding Ubiquitin-like Protein Transferase Activity Identical Protein Binding Protein-membrane Adaptor Activity GTPase Binding	Nucleotide Binding Actin Binding Protein Binding ATP Binding Enzyme Binding Protein Kinase Binding Hsp70 Protein Binding Muramyl Dipeptide Binding Pattern Recognition Receptor Activity Peptidoglycan Binding Ubiquitin Binding Anion Binding ADP Binding Protein-containing Complex Binding CARD Domain Binding Hsp90 Protein Binding Carbohydrate Derivative Binding
	Biological Process	Autophagosome Assembly C-terminal Protein Lipidation Autophagy Positive Regulation Of Autophagy Protein Transport Macroautophagy Microautophagy Hippocampus Development Corpus Callosum Development Protein Localization To Phagophore Assembly Site Negative Stranded Viral RNA Replication Defense Response To Virus Xenophagy Axonal Transport Dendrite Arborization Negative Regulation Of Dendrite Extension	Temperature Homeostasis Pattern Recognition Receptor Signaling Pathway Adaptive Immune Response Immune System Process Positive Regulation Of Dendritic Cell Antigen Processing And Presentation Positive Regulation Of Cytokine Production Involved In Immune Response Positive Regulation Of Dendritic Cell Cytokine Production Positive Regulation Of Type 2 Immune Response Autophagy Defense Response Canonical NF-kappaB Signal Transduction Response To Nutrient Positive Regulation Of Cell Population Proliferation Detection Of Biotic Stimulus Detection Of Bacterium Maintenance Of Gastrointestinal Epithelium Regulation Of Appetite Response To Muramyl Dipeptide Detection Of Muramyl Dipeptide Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-17 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Stress-activated MAPK Cascade Intracellular Signal Transduction Intestinal Stem Cell Homeostasis P38MAPK Cascade Defense Response To Bacterium Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of MAPK Cascade Innate Immune Response Positive Regulation Of Notch Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of JNK Cascade Positive Regulation Of Gamma-delta T Cell Activation Host-mediated Modulation Of Intestinal Microbiota Composition Positive Regulation Of Epithelial Cell Proliferation Regulation Of Inflammatory Response Positive Regulation Of B Cell Activation Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of ERK1 And ERK2 Cascade Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Protein K63-linked Ubiquitination Cellular Response To Lipopolysaccharide Cellular Response To Peptidoglycan Cellular Response To Muramyl Dipeptide Protein Linear Polyubiquitination Antibacterial Innate Immune Response Positive Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Mitophagy Positive Regulation Of Protein K63-linked Ubiquitination Negative Regulation Of Macrophage Apoptotic Process
Pathways		Macroautophagy	NOD1/2 Signaling Pathway NOD1/2 Signaling Pathway TAK1-dependent IKK and NF-kappa-B activation activated TAK1 mediates p38 MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 Ovarian tumor domain proteases Interleukin-1 signaling SARS-CoV-2 activates/modulates innate and adaptive immune responses
Drugs			Mifamurtide
Diseases		Crohn's disease	Crohn's disease Blau syndrome
GWAS		Bilirubin levels ( 31319653 31801373 32084209) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 17435756 17554300 18587394 20570966 21102463 22412388 22936669 23128233 28067908) Inflammatory bowel disease ( 28067908) Pediatric autoimmune diseases ( 26301688) Serum alkaline phosphatase levels ( 33547301)	Asthma ( 32296059 31361310 30929738) Asthma (childhood onset) ( 31036433 30929738) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 17804789 28067908 23128233 22936669 22412388 21102463 20570966 18587394 17554300) Inflammatory bowel disease ( 28067908 18758464) Leprosy ( 25642632 27976721 20018961) Medication use (thyroid preparations) ( 31015401) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Pediatric autoimmune diseases ( 26301688)
Interacting Genes		20 interacting genes: APP ATG5 C3 CRYAA CSNK2A1 CSNK2A2 DEDD2 GAN IFT20 NLRP6 NOD1 NOD2 OPTN RAB33A RAB33B RIPK2 SETD7 TRAF3IP3 WIPI2 ZFP36	38 interacting genes: ALPI ANKHD1 ANXA2 ATG16L1 C10orf67 CCL13 CHMP4B CHMP5 DCTN1 DOCK7 ENTR1 ERBIN GOLGA6L5P GOLGB1 HAP1 IKBIP IRGM LDOC1 LMNA LURAP1L MAP3K7 NLRC4 PDLIM5 PPP1R12C PPP2R3B PRR16 RIPK2 RPL13A SCYL1 TACC3 TNIP1 TPM1 TPM3 TPM4 TRIM41 VCP WBP11 XIAP
Entrez ID		55054	64127
HPRD ID		16498	05810
Ensembl ID		ENSG00000085978	ENSG00000167207
Uniprot IDs		E7EVC7 Q17RG0 Q676U5	A0A286YF65 Q9HC29
PDB IDs		4GDK 4GDL 4NAW 4TQ0 5D7G 5NPV 5NPW 5NUV 5ZYX 7F69 7MU2 7W36 7XFR 8ZQG
Enriched GO Terms of Interacting Partners?		Autophagy Regulation Of Macroautophagy Response To Stress Positive Regulation Of Interleukin-1 Beta Production Regulation Of Autophagy Positive Regulation Of Catabolic Process Positive Regulation Of Interleukin-1 Production Regulation Of Cytokine Production Regulation Of Defense Response Macroautophagy Regulation Of Innate Immune Response Positive Regulation Of Defense Response Positive Regulation Of Autophagy Positive Regulation Of Xenophagy Cell Death Regulation Of Interleukin-1 Beta Production Positive Regulation Of Macroautophagy Cellular Response To Muramyl Dipeptide Protein-containing Complex Regulation Of Interleukin-1 Production Response To Bacterium Intracellular Signal Transduction CARD Domain Binding Signal Transduction Innate Immune Response Immune System Process Programmed Cell Death Regulation Of Immune Response Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of Stress-activated MAPK Cascade Defense Response To Bacterium Response To Muramyl Dipeptide Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Cytokine Production Golgi Apparatus Phagophore Assembly Site Membrane Defense Response To Symbiont Defense Response To Other Organism P38MAPK Cascade Protein Kinase CK2 Complex Protein Localization To Golgi Apparatus Regulation Of Apoptotic Process Autophagosome Assembly Positive Regulation Of Interleukin-6 Production Regulation Of Programmed Cell Death Positive Regulation Of JNK Cascade Negative Regulation Of Canonical NF-kappaB Signal Transduction Cytoplasmic Pattern Recognition Receptor Signaling Pathway Autophagosome Organization Immune Response	Response To Muramyl Dipeptide Cellular Response To Muramyl Dipeptide Response To Lipopolysaccharide Response To Molecule Of Bacterial Origin Muscle Thin Filament Tropomyosin Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Nuclear Migration Response To External Biotic Stimulus Nucleus Localization Stress Fiber Cytosol Pattern Recognition Receptor Signaling Pathway Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Regulation Of Mitotic Spindle Organization Cellular Response To Lipopolysaccharide Innate Immune Response-activating Signaling Pathway Negative Regulation Of Canonical NF-kappaB Signal Transduction Autophagy Autophagosome Maturation Cellular Response To Molecule Of Bacterial Origin C-terminal Protein Lipidation Positive Regulation Of Innate Immune Response Regulation Of Innate Immune Response Activation Of Innate Immune Response Autophagosome Membrane Intracellular Transport Canonical NF-kappaB Signal Transduction P38MAPK Cascade Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Protein Deubiquitination Regulation Of Organelle Organization Vesicle Budding From Membrane Response To Lipid Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway Positive Regulation Of Defense Response Positive Regulation Of Protein Metabolic Process Organelle Localization Cytoplasmic Pattern Recognition Receptor Signaling Pathway Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Defense Response Protein Linear Polyubiquitination Xenophagy Identical Protein Binding Regulation Of Protein Metabolic Process Cellular Localization Endosome Transport Via Multivesicular Body Sorting Pathway Establishment Of Localization In Cell Cellular Response To Oxygen-containing Compound Positive Regulation Of Xenophagy Positive Regulation Of Organelle Organization
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