ATG16L1 and TRAF3IP3

Number of citations of the paper that reports this interaction (PubMedID 27273576)
64

Data Source:
BioGRID (pull down, affinity chromatography technology)

		ATG16L1	TRAF3IP3
Description		autophagy related 16 like 1	TRAF3 interacting protein 3
Image			No pdb structure
GO Annotations	Cellular Component	Autophagosome Membrane Cytoplasm Lysosome Lysosomal Membrane Endosome Autophagosome Cytosol Axoneme Endosome Membrane Membrane Axon Phagophore Assembly Site Membrane Atg12-Atg5-Atg16 Complex Endolysosome Membrane Synapse Sperm Midpiece Glutamatergic Synapse Vacuole-isolation Membrane Contact Site	Golgi Membrane Mitochondrion Mitochondrial Outer Membrane Lysosome Lysosomal Membrane Golgi Apparatus Plasma Membrane Membrane
	Molecular Function	Protein Binding Ubiquitin-like Protein Transferase Activity Identical Protein Binding Protein-membrane Adaptor Activity GTPase Binding	Protein Binding Protein-macromolecule Adaptor Activity Molecular Adaptor Activity
	Biological Process	Autophagosome Assembly C-terminal Protein Lipidation Autophagy Positive Regulation Of Autophagy Protein Transport Macroautophagy Microautophagy Hippocampus Development Corpus Callosum Development Protein Localization To Phagophore Assembly Site Negative Stranded Viral RNA Replication Defense Response To Virus Xenophagy Axonal Transport Dendrite Arborization Negative Regulation Of Dendrite Extension	Cytoplasmic Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Type I Interferon Production
Pathways		Macroautophagy
Drugs
Diseases		Crohn's disease
GWAS		Bilirubin levels ( 31319653 31801373 32084209) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 17435756 17554300 18587394 20570966 21102463 22412388 22936669 23128233 28067908) Inflammatory bowel disease ( 28067908) Pediatric autoimmune diseases ( 26301688) Serum alkaline phosphatase levels ( 33547301)	Alopecia areata ( 25608926) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular volume ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Orofacial clefts ( 33137956) Red blood cell count ( 27863252 32888494) Worry too long after an embarrassing experience ( 29500382)
Interacting Genes		20 interacting genes: APP ATG5 C3 CRYAA CSNK2A1 CSNK2A2 DEDD2 GAN IFT20 NLRP6 NOD1 NOD2 OPTN RAB33A RAB33B RIPK2 SETD7 TRAF3IP3 WIPI2 ZFP36	47 interacting genes: ATG16L1 CBARP CCDC136 CCDC138 CCDC88B CCNC CDCA7L CEP68 CEP70 COQ9 CPLX4 CREB3L3 EBAG9 EMD EVI2B FAM209A FATE1 GOLGA6L9 GOLM2 GORAB GRAMD2A KASH5 KIR2DL3 KRT27 L3MBTL3 LIME1 LRRC25 MFF MINAR1 NDEL1 OSBPL3 PLEKHO1 PSTPIP1 RACGAP1 RIC3 RILPL1 SP100 STMN4 STX1A STX4 TFIP11 TMEM139 TRAF3 TRIM36 WAC ZNRD2 ZRANB1
Entrez ID		55054	80342
HPRD ID		16498	16305
Ensembl ID		ENSG00000085978	ENSG00000009790
Uniprot IDs		E7EVC7 Q17RG0 Q676U5	B1AJU2 B3KWQ9 E2QRE5 Q9Y228
PDB IDs		4GDK 4GDL 4NAW 4TQ0 5D7G 5NPV 5NPW 5NUV 5ZYX 7F69 7MU2 7W36 7XFR 8ZQG
Enriched GO Terms of Interacting Partners?		Autophagy Regulation Of Macroautophagy Response To Stress Positive Regulation Of Interleukin-1 Beta Production Regulation Of Autophagy Positive Regulation Of Catabolic Process Positive Regulation Of Interleukin-1 Production Regulation Of Cytokine Production Regulation Of Defense Response Macroautophagy Regulation Of Innate Immune Response Positive Regulation Of Defense Response Positive Regulation Of Autophagy Positive Regulation Of Xenophagy Cell Death Regulation Of Interleukin-1 Beta Production Positive Regulation Of Macroautophagy Cellular Response To Muramyl Dipeptide Protein-containing Complex Regulation Of Interleukin-1 Production Response To Bacterium Intracellular Signal Transduction CARD Domain Binding Signal Transduction Innate Immune Response Immune System Process Programmed Cell Death Regulation Of Immune Response Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of Stress-activated MAPK Cascade Defense Response To Bacterium Response To Muramyl Dipeptide Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Cytokine Production Golgi Apparatus Phagophore Assembly Site Membrane Defense Response To Symbiont Defense Response To Other Organism P38MAPK Cascade Protein Kinase CK2 Complex Protein Localization To Golgi Apparatus Regulation Of Apoptotic Process Autophagosome Assembly Positive Regulation Of Interleukin-6 Production Regulation Of Programmed Cell Death Positive Regulation Of JNK Cascade Negative Regulation Of Canonical NF-kappaB Signal Transduction Cytoplasmic Pattern Recognition Receptor Signaling Pathway Autophagosome Organization Immune Response	Identical Protein Binding Organelle Organization
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