PICK1 and GRIA1

Number of citations of the paper that reports this interaction (PubMedID 11891216)
0

Data Source:
HPRD (in vitro)

		PICK1	GRIA1
Description		protein interacting with PRKCA 1	glutamate ionotropic receptor AMPA type subunit 1
Image
GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Cytosol Cytoskeleton Plasma Membrane Synaptic Vesicle Postsynaptic Density Membrane Endocytic Vesicle Membrane Trans-Golgi Network Membrane Presynaptic Membrane Neuron Projection Synapse Perinuclear Region Of Cytoplasm	Endosome Early Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Cell-cell Junction Synaptic Vesicle Ionotropic Glutamate Receptor Complex External Side Of Plasma Membrane Cell Surface ER To Golgi Transport Vesicle Membrane Postsynaptic Density Membrane Dendrite Endocytic Vesicle Membrane Synaptic Vesicle Membrane Neuromuscular Junction Early Endosome Membrane Asymmetric Synapse AMPA Glutamate Receptor Complex Dendrite Membrane Dendritic Spine Membrane Neuronal Cell Body Membrane Protein-containing Complex Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Somatodendritic Compartment Presynaptic Membrane Cell Projection Neuron Projection Neuronal Cell Body Dendritic Spine Dendritic Shaft Cell Body Axonal Spine Neuron Spine Synapse Postsynaptic Membrane Presynaptic Active Zone Membrane Recycling Endosome Recycling Endosome Membrane Excitatory Synapse Synaptic Membrane Presynapse Postsynapse Postsynaptic Density Membrane Glutamatergic Synapse Postsynaptic Density, Intracellular Component Perisynaptic Space Proximal Dendrite
	Molecular Function	G Protein-coupled Receptor Binding Actin Binding Protein Kinase C Binding Signaling Receptor Binding Protein Binding Phospholipid Binding Protein Domain Specific Binding Identical Protein Binding Metal Ion Binding Actin Filament Binding Arp2/3 Complex Binding Membrane Curvature Sensor Activity	Amyloid-beta Binding G-protein Alpha-subunit Binding Glutamate-gated Receptor Activity AMPA Glutamate Receptor Activity Monoatomic Ion Channel Activity Protein Binding Adenylate Cyclase Binding Ligand-gated Monoatomic Ion Channel Activity Immunoglobulin Binding Protein Kinase Binding Protein Domain Specific Binding Glutamate-gated Calcium Ion Channel Activity PDZ Domain Binding Small GTPase Binding Myosin V Binding G-protein Beta-subunit Binding Beta-2 Adrenergic Receptor Binding Glutamate Receptor Binding Signaling Receptor Activity Identical Protein Binding Protein Kinase A Binding Peptide Hormone Receptor Binding Scaffold Protein Binding Ligand-gated Monoatomic Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential
	Biological Process	Positive Regulation Of Receptor Internalization Protein Phosphorylation Intracellular Protein Transport Monoamine Transport Glial Cell Development Regulation Of Arp2/3 Complex-mediated Actin Nucleation Negative Regulation Of Arp2/3 Complex-mediated Actin Nucleation Cellular Response To Decreased Oxygen Levels Cellular Response To Glucose Starvation Receptor Clustering Neuronal Ion Channel Clustering Regulation Of Insulin Secretion Long-term Synaptic Depression Dendritic Spine Organization Dendritic Spine Maintenance	Regulation Of Receptor Recycling Monoatomic Ion Transport Signal Transduction Chemical Synaptic Transmission Synapse Assembly Long-term Memory Response To Xenobiotic Stimulus Response To Toxic Substance Response To Sucrose Response To Lithium Ion Positive Regulation Of Gene Expression Neuronal Action Potential Calcium-mediated Signaling Spinal Cord Development Cerebral Cortex Development Receptor Internalization Response To Nutrient Levels Response To Estradiol Monoatomic Ion Transmembrane Transport Regulation Of Monoatomic Ion Transmembrane Transport Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Response To Cocaine Response To Morphine Response To Peptide Hormone Response To Ethanol Positive Regulation Of Membrane Potential Response To Arsenic-containing Substance Regulation Of Synaptic Plasticity Behavioral Response To Pain Modulation Of Chemical Synaptic Transmission Positive Regulation Of Synaptic Transmission Response To Electrical Stimulus Regulation Of Postsynaptic Membrane Potential Long-term Synaptic Potentiation Long-term Synaptic Depression Response To Fungicide Cellular Response To Amino Acid Stimulus Cellular Response To Ammonium Ion Cellular Response To DsRNA Cellular Response To Growth Factor Stimulus Cellular Response To Peptide Hormone Stimulus Cellular Response To Amine Stimulus Positive Regulation Of Locomotion Involved In Locomotory Behavior Regulation Of Presynaptic Membrane Potential Cellular Response To L-glutamate Cellular Response To Brain-derived Neurotrophic Factor Stimulus Conditioned Place Preference Response To Psychosocial Stress Positive Regulation Of Excitatory Postsynaptic Potential
Pathways		Cell surface interactions at the vascular wall Trafficking of GluR2-containing AMPA receptors	COPII-mediated vesicle transport Activation of AMPA receptors Trafficking of AMPA receptors Trafficking of GluR2-containing AMPA receptors Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Cargo concentration in the ER Synaptic adhesion-like molecules Long-term potentiation
Drugs			Glutamic acid Butabarbital Lamotrigine Isoflurane Ethanol Methoxyflurane Desflurane Sevoflurane Talampanel CX-717 CX516 Perampanel Tianeptine Fluciclovine (18F)
Diseases
GWAS		Body fat percentage ( 26833246) Brain morphology (MOSTest) ( 32665545) Mean platelet volume ( 32888494)	Adult body size ( 32376654) Aging (time to event) ( 21782286) Anthropometric traits ( 19260139) Asparaginase hypersensitivity in acute lymphoblastic leukemia ( 20592726) Chronotype ( 30696823) General risk tolerance (MTAG) ( 30643258) Hand grip strength ( 29691431) HDL cholesterol levels ( 32203549) Interleukin-6 levels ( 22205395) Middle childhood and early adolescence aggressive behavior ( 26087016) Morning person ( 30696823) Obesity-related traits ( 23251661) Post bronchodilator FEV1 in COPD ( 26634245) Schizophrenia ( 30285260 28991256 25056061 23974872) Sleep (1/3-day periodicity) ( 33075057) Sudden cardiac arrest ( 21658281) Survival in microsatellite instability low/stable colorectal cancer ( 25866641)
Interacting Genes		385 interacting genes: ABT1 AEBP2 AFDN AIRE AKT1 AKT2 ALKBH8 AP1M1 AP1S1 APTX AQP1 ARF1 ARF3 ARHGEF3 ARHGEF5 ARL6IP1 ARMCX1 ASIC1 ASIC2 ATOSB ATP5IF1 ATXN1L ATXN3 ATXN7 ATXN7L3 AVPI1 BAHD1 BCL2L14 BEX1 BLK BLOC1S2 BOLA3 BRD1 BTG2 BUD31 BYSL C1orf35 C2CD5 C4orf46 C8orf33 CACNA1C CARD9 CBX8 CCDC102B CCDC187 CCNH CDC42EP2 CDC73 CDCA7L CDK2AP1 CDKL3 CDKN2B CDKN2D CEP19 CEP290 CEP57L1 CEP89 CEP95 CGGBP1 CHMP1B CIC COIL CPNE2 CPNE7 CRY2 CSNK2A2 CTNNB1 CTSG CUTC CWF19L2 CYP21A2 DCTD DCUN1D5 DDX55 DDX6 DLG4 DMC1 DMD DNAAF19 DNAJB13 DNMT1 DNTTIP1 DNTTIP2 DPF2 DRAP1 DSCR9 DTNB DUSP29 EAF1 EEF2KMT EFHC2 EFNB1 EFNB2 EHD2 EHHADH EIF1AD EIF3D EIF4A3 EIF4EBP1 EIF4H EIF5A ENKD1 EPHB2 EPM2AIP1 ERBB2 ERBIN ESCO2 EXOSC5 F11R FAM161A FAM161B FAM219B FAM90A1 FAM9A FBXL3 FBXL8 FGF16 FKBP6 FLYWCH1 FMR1 FXN FXR2 GADD45GIP1 GAS2L2 GFI1 GFI1B GLYCTK GPATCH11 GPATCH2 GPC4 GPKOW GRB10 GRB7 GRIA1 GRIA2 GRIA3 GRIA4 GRIK1 GRIK2 GRIP1 GRM3 GRM7 GRXCR1 GSK3B GTF2E2 GTPBP2 HDAC4 HEXIM2 HMBOX1 HMBS HMG20A HOPX HOXA5 HSD17B14 HSF2 HSF2BP HUNK ID2 IHO1 IL16 ILF2 INO80B INO80E INPP5J IP6K1 ISCU JAM2 JAM3 JRK KAT5 KCNJ6 KCTD1 KCTD6 KCTD9 KIAA1328 L3MBTL2 LCLAT1 LCN2 LGALS14 LMO1 LMO3 LONRF1 LRP2BP LRRC73 LZTFL1 LZTS1 MAGEA4 MAGEB4 MAP2K6 MAPK9 MAPRE3 MAZ MBD3 MCM10 MEOX2 MGME1 MID2 MNS1 MOB3C MORF4L1 MORF4L2 MORN3 MOS MRI1 MRNIP MSRB3 MSS51 MTA1 MTG1 NATD1 NCOA5 NDEL1 NECAB2 NECTIN2 NECTIN3 NECTIN4 NEK6 NLGN3 NME7 NMNAT1 NOC4L OARD1 OPTN OSBP2 OSGIN1 OSTF1 PAFAH1B3 PAX6 PBX4 PCBD1 PDCD5 PDS5A PEBP1 PHF19 PIBF1 PKN1 PKNOX2 PLEKHA7 PNKP PNO1 POLL POLR3C PPARA PPL PRKCA PRKCG PRKN PRLHR PRPF18 PRPF31 PRPF40A PSMA1 PSME3 PTEN PTRH1 QARS1 RAD51D RASAL3 RCAN1 REEP6 REL RFC3 RIMS3 RIN1 RNF8 RNPS1 ROBO3 ROPN1 RPIA RPP25 RRP8 RUNX1 RXRB RXRG SACS SCAND1 SCNM1 SEMA3B SEPTIN1 SERBP1 SERTAD1 SERTAD3 SH2D4A SH3GLB2 SHFL SLC6A3 SLIRP SLX9 SMARCA2 SMARCB1 SMARCD1 SNRNP25 SNRPA1 SNRPB2 SNW1 SPANXN2 SPATC1L SPEG SSNA1 STK4 SYT17 TBC1D22B TBC1D26 TBC1D7 TCEA2 TCEANC TCEANC2 TDO2 TEX101 TFIP11 THAP6 THAP7 TLE5 TLNRD1 TPM4 TRAF4 TRAF5 TRIM44 TRIM54 TRIML2 TRMT2A TSC1 TSC2 TSGA10IP TSN TSPAN7 TSTD2 TTC23 TTC23L TXNDC9 TXNL4B TYW3 UBE2E3 UBE2K UBQLN4 USHBP1 USP2 USP7 UTP3 VAX1 VEZF1 VPS25 WHR1 WT1 XPA YES1 YPEL2 YTHDC1 ZBED1 ZBTB2 ZBTB24 ZBTB49 ZFHX3 ZFP2 ZFP91 ZMAT2 ZMYND12 ZNF165 ZNF17 ZNF205 ZNF250 ZNF264 ZNF276 ZNF286A ZNF329 ZNF330 ZNF35 ZNF408 ZNF410 ZNF414 ZNF417 ZNF438 ZNF497 ZNF524 ZNF575 ZNF576 ZNF593 ZNF624 ZNF691 ZNF71 ZNF764 ZNF774 ZSCAN21 ZSCAN23 ZZZ3	27 interacting genes: CACNG2 CAMK2A CAMK2G CANX CASP8 CXCR2 CYLD DLG1 EPB41L1 EPB41L2 GRIA4 GRID2 GRIK2 GRIP1 GRIPAP1 HOMER1 HSPA5 NEDD4L PICK1 PRKACA PRKCA RPS6KB1 SDCBP SQSTM1 TANC1 TRPC1 USP46
Entrez ID		9463	2890
HPRD ID		16176	00695
Ensembl ID		ENSG00000100151	ENSG00000155511
Uniprot IDs		Q9NRD5	A0A9L9PXG3 P42261 Q59GL5
PDB IDs		2GZV 6AR4 6BJN 6BJO	6X5Q
Enriched GO Terms of Interacting Partners?		Protein Binding Nucleus Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Identical Protein Binding Nucleoplasm Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Regulation Of Transcription By RNA Polymerase II Regulation Of Metabolic Process Zinc Ion Binding DNA Binding Nucleic Acid Metabolic Process Glutamate-gated Receptor Activity Nuclear Speck Negative Regulation Of Macromolecule Metabolic Process Glutamate Receptor Signaling Pathway Negative Regulation Of Metabolic Process Regulation Of DNA Repair Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of DNA Repair Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Biosynthetic Process Postsynaptic Membrane Negative Regulation Of DNA-templated Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II AMPA Glutamate Receptor Activity Ionotropic Glutamate Receptor Signaling Pathway Postsynaptic Density Membrane Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Metabolic Process Regulation Of Circadian Rhythm TSC1-TSC2 Complex Nucleobase-containing Compound Metabolic Process DNA Metabolic Process MRNA Splicing, Via Spliceosome Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of DNA Metabolic Process RNA Splicing, Via Transesterification Reactions Glutamate-gated Calcium Ion Channel Activity Regulation Of Double-strand Break Repair	Synapse Modulation Of Chemical Synaptic Transmission Glutamatergic Synapse Regulation Of Protein Localization To Cell Periphery Postsynaptic Density Regulation Of Protein Localization Neuron Projection Regulation Of Cell Communication Regulation Of Signaling Endocytic Vesicle Membrane Ionotropic Glutamate Receptor Binding Regulation Of Transport Regulation Of Protein Localization To Membrane Regulation Of Biological Quality Postsynaptic Density Membrane Regulation Of Synaptic Plasticity Plasma Membrane Regulation Of Apoptotic Process Regulation Of Metal Ion Transport Regulation Of Programmed Cell Death Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Cellular Component Organization Glutamate Receptor Signaling Pathway Positive Regulation Of Synaptic Transmission Regulation Of Monoatomic Ion Transport Positive Regulation Of Transport Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Positive Regulation Of Protein Localization Intracellular Signaling Cassette Dendrite Positive Regulation Of Protein Localization To Cell Periphery Negative Regulation Of Programmed Cell Death Intracellular Protein Localization Proteolysis Involved In Protein Catabolic Process Proteolysis Chemical Synaptic Transmission AMPA Glutamate Receptor Complex Trans-synaptic Signaling Cortical Actin Cytoskeleton Organization Ionotropic Glutamate Receptor Signaling Pathway Ionotropic Glutamate Receptor Complex Regulation Of Cellular Localization Protein Phosphorylation Synaptic Signaling Establishment Of Protein Localization Protein Localization To Postsynaptic Membrane Ligand-gated Monoatomic Ion Channel Activity Protein Localization To Postsynapse
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