PICK1 and COIL

Number of citations of the paper that reports this interaction (PMID 16713569)
214

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		PICK1	COIL
Gene Name		protein interacting with PRKCA 1	coilin
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Mitochondrion Golgi Apparatus Cytoskeleton Plasma Membrane Cell Junction Endocytic Vesicle Membrane Presynaptic Membrane Neuron Projection Synapse Postsynaptic Membrane Perinuclear Region Of Cytoplasm Neuronal Postsynaptic Density	Nucleus Nucleoplasm Nucleolus Cytoplasm Cajal Body Membrane
	Molecular Function	G-protein Coupled Receptor Binding Protein Kinase C Binding Receptor Binding Protein Binding Protein C-terminus Binding ATPase Activity Enzyme Binding Protein Domain Specific Binding Identical Protein Binding Metal Ion Binding Actin Filament Binding Arp2/3 Complex Binding	Protein Binding Protein C-terminus Binding Identical Protein Binding
	Biological Process	Positive Regulation Of Receptor Internalization Protein Phosphorylation Protein Targeting Retrograde Vesicle-mediated Transport, Golgi To ER Protein Kinase C-activating G-protein Coupled Receptor Signaling Pathway Synaptic Transmission Monoamine Transport Glial Cell Development Negative Regulation Of Arp2/3 Complex-mediated Actin Nucleation Cellular Response To Decreased Oxygen Levels Cellular Response To Glucose Starvation DNA Methylation Involved In Embryo Development DNA Methylation Involved In Gamete Generation Receptor Clustering Neuronal Ion Channel Clustering Long Term Synaptic Depression Dendritic Spine Organization Dendritic Spine Maintenance
Pathways		Trafficking of GluR2-containing AMPA receptors Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity Trafficking of AMPA receptors Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Transmission across Chemical Synapses
Drugs
Diseases
GWAS			Height ( 18391951)
Protein-Protein Interactions		47 interactors: APTX AQP1 ARF1 ARF3 ASIC1 ASIC2 ATXN1L ATXN3 ATXN7 ATXN7L3 BTG2 CIC COIL CTNNB1 EFNB1 EFNB2 EHD2 EPHB2 ERBB2 ERBB2IP F11R FXN GFI1 GFI1B GRIA1 GRIA2 GRIA3 GRIA4 GRIK1 GRIK2 GRIK3 GRIP1 GRM3 GRM7 JAM3 LRP2BP MLLT4 PARK2 PRKCA PRKCG PRLHR PVRL2 PVRL4 SACS SLC6A3 UBQLN4 USP7	70 interactors: ACTN1 ACTN2 ACTN4 APP ARMCX1 ATXN1 ATXN1L BYSL C1QBP CCDC136 CCDC159 CCNE1 CDC23 CDK2 CEP70 CEP76 CSNK2B CYB5R2 DHX16 DNAJA3 DRG1 FGF12 FHL5 FXR2 GCC1 KALRN KAZN KLC2 KLC4 KLHL42 KLHL8 KPNA3 LNX1 MAD1L1 MFAP1 MYO5B NIF3L1 NOLC1 NUDT18 PDE4D PDLIM5 PIAS4 PICK1 PLEKHG4 POLR2L PREPL PRMT1 PRMT8 PSMA1 PSME3 PTS SART3 SCYL1 SMN1 SNRPB SNRPF SNX6 TAF9 TCAF1 TCEB3B TFCP2 TGS1 TSPYL2 WDR34 WDYHV1 XRCC5 XRCC6 ZBTB25 ZCCHC10 ZNF277
Entrez ID		9463	8161
HPRD ID		16176	02605
Ensembl ID		ENSG00000100151	ENSG00000121058
Uniprot IDs		B3KS52 Q9NRD5	P38432
PDB IDs		2GZV
Enriched GO Terms of Interacting Partners?		Cell-cell Signaling Synaptic Transmission Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Ionotropic Glutamate Receptor Signaling Pathway Neuron-neuron Synaptic Transmission Cellular Response To Stimulus Regulation Of Cellular Process Response To Stimulus Signaling Cell Communication Behavior Regulation Of Synaptic Transmission Single-organism Behavior Neurological System Process Negative Regulation Of Synaptic Transmission Regulation Of Synaptic Transmission, Glutamatergic Signal Transduction Adenylate Cyclase-inhibiting G-protein Coupled Glutamate Receptor Signaling Pathway Anatomical Structure Development Cell Surface Receptor Signaling Pathway Regulation Of Cellular Component Organization Nervous System Development Negative Regulation Of Synaptic Transmission, Glutamatergic Cell Junction Assembly Developmental Process Ion Transport Cell-cell Junction Organization Ion Transmembrane Transport G-protein Coupled Glutamate Receptor Signaling Pathway Histone Deubiquitination Learning Or Memory Negative Regulation Of Adenylate Cyclase Activity Multicellular Organismal Development Regulation Of Body Fluid Levels Negative Regulation Of Lyase Activity Establishment Of Endothelial Barrier Cognition Response To External Stimulus System Development Regulation Of Signaling Adherens Junction Organization Multicellular Organismal Response To Stress Negative Regulation Of CAMP Biosynthetic Process Cellular Process Negative Regulation Of CAMP Metabolic Process Sensory Perception Of Sour Taste Negative Regulation Of Apoptotic Process Negative Regulation Of Neuron Death Negative Regulation Of Programmed Cell Death	Cellular Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Spliceosomal SnRNP Assembly Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process RNA Metabolic Process Regulation Of Metabolic Process MRNA Processing Ribonucleoprotein Complex Biogenesis RNA Processing Regulation Of Nitrogen Compound Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Mitotic Cell Cycle RNA Splicing Gene Expression Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Ribonucleoprotein Complex Assembly Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Hyperosmotic Salinity Response Protein Localization To Tight Junction Regulation Of Cellular Protein Metabolic Process Mitotic Cell Cycle Process Regulation Of RNA Metabolic Process MRNA Metabolic Process Transcription, DNA-templated Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Cellular Metabolic Process Cellular Metabolic Process Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Regulation Of Cell Cycle Phase Transition RNA Biosynthetic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Process Regulation Of Protein Metabolic Process Platelet Degranulation Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Macromolecular Complex Assembly Negative Regulation Of Cellular Protein Metabolic Process Mitotic Cell Cycle Checkpoint DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Gene Expression Cellular Response To X-ray Regulation Of Ubiquitin-protein Transferase Activity Viral Process Cellular Component Assembly
Tagcloud ?		altering ampa calsyntenin clarified confirming coordinated deprivation elicited excitotoxic glua1 glun2a glun2b glun3a grip1 hippocampal insults ionotropic ischemia ogd profound proteome repression sapap2 snap submitted synaptic tarpgamma3 transcriptome vulnerability	augment augments bait cbp coactivator coiled enhances except hybrid ifngamma instead interactor interacts interestingly intrinsic lacks myc nmi potentiate recruitment reveal screen stat stat1 stat2 stat5 stat5b stats yeast
Tagcloud (Difference) ?		altering ampa calsyntenin clarified confirming coordinated deprivation elicited excitotoxic glua1 glun2a glun2b glun3a grip1 hippocampal insults ionotropic ischemia ogd profound proteome repression sapap2 snap submitted synaptic tarpgamma3 transcriptome vulnerability	augment augments bait cbp coactivator coiled enhances except hybrid ifngamma instead interactor interacts interestingly intrinsic lacks myc nmi potentiate recruitment reveal screen stat stat1 stat2 stat5 stat5b stats yeast
Tagcloud (Intersection) ?