PICK1 and PRLHR

Number of citations of the paper that reports this interaction (PMID 11641419)
6

Data Source:
HPRD (in vitro, in vivo)

		PICK1	PRLHR
Gene Name		protein interacting with PRKCA 1	prolactin releasing hormone receptor
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Mitochondrion Golgi Apparatus Cytoskeleton Plasma Membrane Cell Junction Endocytic Vesicle Membrane Presynaptic Membrane Neuron Projection Synapse Postsynaptic Membrane Perinuclear Region Of Cytoplasm Neuronal Postsynaptic Density	Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	G-protein Coupled Receptor Binding Protein Kinase C Binding Receptor Binding Protein Binding Protein C-terminus Binding ATPase Activity Enzyme Binding Protein Domain Specific Binding Identical Protein Binding Metal Ion Binding Actin Filament Binding Arp2/3 Complex Binding	G-protein Coupled Receptor Activity Neuropeptide Y Receptor Activity Protein Binding Neuropeptide Receptor Activity
	Biological Process	Positive Regulation Of Receptor Internalization Protein Phosphorylation Protein Targeting Retrograde Vesicle-mediated Transport, Golgi To ER Protein Kinase C-activating G-protein Coupled Receptor Signaling Pathway Synaptic Transmission Monoamine Transport Glial Cell Development Negative Regulation Of Arp2/3 Complex-mediated Actin Nucleation Cellular Response To Decreased Oxygen Levels Cellular Response To Glucose Starvation DNA Methylation Involved In Embryo Development DNA Methylation Involved In Gamete Generation Receptor Clustering Neuronal Ion Channel Clustering Long Term Synaptic Depression Dendritic Spine Organization Dendritic Spine Maintenance	G-protein Coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Female Pregnancy Feeding Behavior Hormone Metabolic Process
Pathways		Trafficking of GluR2-containing AMPA receptors Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity Trafficking of AMPA receptors Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Transmission across Chemical Synapses	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Peptide ligand-binding receptors Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs
Diseases
GWAS			Pancreatic cancer ( 22158540)
Protein-Protein Interactions		47 interactors: APTX AQP1 ARF1 ARF3 ASIC1 ASIC2 ATXN1L ATXN3 ATXN7 ATXN7L3 BTG2 CIC COIL CTNNB1 EFNB1 EFNB2 EHD2 EPHB2 ERBB2 ERBB2IP F11R FXN GFI1 GFI1B GRIA1 GRIA2 GRIA3 GRIA4 GRIK1 GRIK2 GRIK3 GRIP1 GRM3 GRM7 JAM3 LRP2BP MLLT4 PARK2 PRKCA PRKCG PRLHR PVRL2 PVRL4 SACS SLC6A3 UBQLN4 USP7	3 interactors: PICK1 PRLH SNTA1
Entrez ID		9463	2834
HPRD ID		16176	02937
Ensembl ID		ENSG00000100151	ENSG00000119973
Uniprot IDs		B3KS52 Q9NRD5	A5JUU5 P49683
PDB IDs		2GZV
Enriched GO Terms of Interacting Partners?		Cell-cell Signaling Synaptic Transmission Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Ionotropic Glutamate Receptor Signaling Pathway Neuron-neuron Synaptic Transmission Cellular Response To Stimulus Regulation Of Cellular Process Response To Stimulus Signaling Cell Communication Behavior Regulation Of Synaptic Transmission Single-organism Behavior Neurological System Process Negative Regulation Of Synaptic Transmission Regulation Of Synaptic Transmission, Glutamatergic Signal Transduction Adenylate Cyclase-inhibiting G-protein Coupled Glutamate Receptor Signaling Pathway Anatomical Structure Development Cell Surface Receptor Signaling Pathway Regulation Of Cellular Component Organization Nervous System Development Negative Regulation Of Synaptic Transmission, Glutamatergic Cell Junction Assembly Developmental Process Ion Transport Cell-cell Junction Organization Ion Transmembrane Transport G-protein Coupled Glutamate Receptor Signaling Pathway Histone Deubiquitination Learning Or Memory Negative Regulation Of Adenylate Cyclase Activity Multicellular Organismal Development Regulation Of Body Fluid Levels Negative Regulation Of Lyase Activity Establishment Of Endothelial Barrier Cognition Response To External Stimulus System Development Regulation Of Signaling Adherens Junction Organization Multicellular Organismal Response To Stress Negative Regulation Of CAMP Biosynthetic Process Cellular Process Negative Regulation Of CAMP Metabolic Process Sensory Perception Of Sour Taste Negative Regulation Of Apoptotic Process Negative Regulation Of Neuron Death Negative Regulation Of Programmed Cell Death	Regulation Of Vasoconstriction By Circulating Norepinephrine Reduction Of Food Intake In Response To Dietary Excess Negative Regulation Of Peptidyl-cysteine S-nitrosylation Regulation Of Actin Filament-based Process DNA Methylation Involved In Embryo Development Response To Nutrient Levels Dendritic Spine Maintenance Response To Extracellular Stimulus Neuronal Ion Channel Clustering Negative Regulation Of Arp2/3 Complex-mediated Actin Nucleation Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Negative Regulation Of Actin Nucleation Long Term Synaptic Depression Response To Dietary Excess Positive Regulation Of Receptor Internalization Ventricular Cardiac Muscle Cell Action Potential Regulation Of Arp2/3 Complex-mediated Actin Nucleation Dendritic Spine Organization Regulation Of Membrane Repolarization DNA Methylation Involved In Gamete Generation Regulation Of Actin Nucleation Cellular Response To Glucose Starvation Monoamine Transport Cellular Component Maintenance Cardiac Muscle Cell Action Potential Involved In Contraction Eating Behavior Neuron Maturation Regulation Of Receptor Internalization Regulation Of Sodium Ion Transmembrane Transport Retrograde Vesicle-mediated Transport, Golgi To ER Cardiac Muscle Cell Action Potential Positive Regulation Of Receptor-mediated Endocytosis Autonomic Nervous System Development Regulation Of Cardiac Muscle Cell Contraction Protein Kinase C-activating G-protein Coupled Receptor Signaling Pathway Receptor Clustering Neuromuscular Junction Development G-protein Coupled Receptor Signaling Pathway Regulation Of Vasoconstriction DNA Methylation Negative Regulation Of Synaptic Transmission Regulation Of Sodium Ion Transport Regulation Of Heart Rate Regulation Of Cardiac Muscle Contraction Regulation Of Striated Muscle Contraction Action Potential DNA Modification Feeding Behavior Regulation Of Multicellular Organism Growth Cellular Response To Decreased Oxygen Levels
Tagcloud ?		altering ampa calsyntenin clarified confirming coordinated deprivation elicited excitotoxic glua1 glun2a glun2b glun3a grip1 hippocampal insults ionotropic ischemia ogd profound proteome repression sapap2 snap submitted synaptic tarpgamma3 transcriptome vulnerability	accounts brown calb1 call creeping cutoffs egg eggshell empirical footprints gal gaps heterozygosity hypotheses insr lepr localizing moving nramp1 outliers permutation scanned sliding statistic subjectively sweeps tails window windows
Tagcloud (Difference) ?		altering ampa calsyntenin clarified confirming coordinated deprivation elicited excitotoxic glua1 glun2a glun2b glun3a grip1 hippocampal insults ionotropic ischemia ogd profound proteome repression sapap2 snap submitted synaptic tarpgamma3 transcriptome vulnerability	accounts brown calb1 call creeping cutoffs egg eggshell empirical footprints gal gaps heterozygosity hypotheses insr lepr localizing moving nramp1 outliers permutation scanned sliding statistic subjectively sweeps tails window windows
Tagcloud (Intersection) ?