EIF2AK3 and NFE2L2

Number of citations of the paper that reports this interaction (PMID 14517290)
133

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		EIF2AK3	NFE2L2
Gene Name		eukaryotic translation initiation factor 2-alpha kinase 3	nuclear factor, erythroid 2-like 2
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Gene Ontology Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane	Chromatin Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Plasma Membrane
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Eukaryotic Translation Initiation Factor 2alpha Kinase Activity Protein Binding ATP Binding Enzyme Binding Protein Phosphatase Binding Identical Protein Binding	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding RNA Polymerase II Activating Transcription Factor Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Transcription Cofactor Binding DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Protein Domain Specific Binding Transcription Regulatory Region DNA Binding
	Biological Process	Skeletal System Development Ossification Angiogenesis Chondrocyte Development Translation Protein Phosphorylation Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process ER Overload Response Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Endoplasmic Reticulum Organization Lactation Positive Regulation Vascular Endothelial Growth Factor Production Positive Regulation Of Gene Expression Regulation Of Translational Initiation By EIF2 Alpha Phosphorylation Negative Regulation Of Translation Peptidyl-serine Phosphorylation Regulation Of Fatty Acid Metabolic Process Calcium-mediated Signaling Insulin Secretion Bone Mineralization Endoplasmic Reticulum Unfolded Protein Response Endocrine Pancreas Development Negative Regulation Of Myelination Negative Regulation Of Translational Initiation In Response To Stress Positive Regulation Of Protein Binding SREBP Signaling Pathway Response To Endoplasmic Reticulum Stress Cellular Response To Glucose Starvation Negative Regulation Of Apoptotic Process Cellular Protein Metabolic Process Fat Cell Differentiation Positive Regulation Of Transcription From RNA Polymerase I Promoter Protein Autophosphorylation Insulin-like Growth Factor Receptor Signaling Pathway Protein Homooligomerization Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Positive Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway	Transcription From RNA Polymerase II Promoter Proteasomal Ubiquitin-independent Protein Catabolic Process Positive Regulation Of Gene Expression Protein Ubiquitination Positive Regulation Of Blood Coagulation Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Embryonic Development Cellular Response To Hydrogen Peroxide Cellular Response To Tumor Necrosis Factor Cellular Response To Fluid Shear Stress Cellular Response To Laminar Fluid Shear Stress Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Hydrogen Peroxide-induced Cell Death Regulation Of Removal Of Superoxide Radicals Negative Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		PERK regulates gene expression Unfolded Protein Response (UPR)
Drugs
Diseases
GWAS		Height ( 20881960) Progressive supranuclear palsy ( 21685912)
Protein-Protein Interactions		6 interactors: DNAJC3 EIF2S1 HSP90AA1 HSPA5 IKBKB NFE2L2	35 interactors: ATF4 BPTF CASP1 CASP3 CHD6 COPS7A CREB3 CREBBP DYT10 EIF2AK3 GSK3B JUN JUND KEAP1 KPNA3 MAFF MAFG MAFK MAPK7 NCOR2 NFE2 NFE2L3 PMF1 PPARG PRKCA PRKCD PRKCG PRKCH PRKCQ RBMX SUMO1 TNNT1 TRIM24 UBE2E2 WAC
Entrez ID		9451	4780
HPRD ID		04942	02732
Ensembl ID		ENSG00000172071	ENSG00000116044
Uniprot IDs		B3KY45 Q9NZJ5	Q16236
PDB IDs		4G31 4G34	2FLU 2LZ1 3ZGC
Enriched GO Terms of Interacting Partners?		Response To Unfolded Protein Endoplasmic Reticulum Unfolded Protein Response Cellular Response To Unfolded Protein ER-nucleus Signaling Pathway Cellular Response To Topologically Incorrect Protein Response To Endoplasmic Reticulum Stress Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Positive Regulation Of Nuclease Activity Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Cellular Response To Stress Positive Regulation Of Metabolic Process Response To Stress Cellular Response To Organic Substance Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Cellular Protein Metabolic Process Negative Regulation Of Cell Death Regulation Of Nitrogen Compound Metabolic Process Signal Transduction Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Protein Metabolic Process Signaling Positive Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Apoptotic Process Cell Communication Proteolysis Involved In Cellular Protein Catabolic Process Regulation Of Cell Death Positive Regulation Of Transferase Activity Regulation Of Protein Folding In Endoplasmic Reticulum Cellular Protein Catabolic Process Cellular Response To Tumor Necrosis Factor Cellular Response To Cytokine Stimulus Protein Catabolic Process Response To Tumor Necrosis Factor Response To External Stimulus Cellular Response To Stimulus Cerebellum Structural Organization Response To Cytokine Positive Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Response To Biotic Stimulus Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Kinase Activity Cellular Macromolecule Catabolic Process Positive Regulation Of Phosphorylation Protein Import Into Mitochondrial Outer Membrane Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress Proteasomal Ubiquitin-independent Protein Catabolic Process	Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of Transcription, DNA-templated Response To Stress Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Regulation Of RNA Metabolic Process Cellular Response To Organic Substance Regulation Of Metabolic Process Transcription, DNA-templated Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process RNA Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Response To Organic Substance Regulation Of Body Fluid Levels Regulation Of Apoptotic Process Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Gene Expression Regulation Of Cell Death Response To Stimulus Transcription From RNA Polymerase II Promoter Response To Wounding Cellular Metabolic Process Negative Regulation Of Cell Death Positive Regulation Of Protein Metabolic Process Blood Coagulation Cellular Macromolecule Biosynthetic Process RNA Metabolic Process Hemostasis Cellular Response To Stress Regulation Of Transcription From RNA Polymerase II Promoter Nucleobase-containing Compound Metabolic Process Macromolecule Biosynthetic Process Innate Immune Response Regulation Of Protein Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Cellular Response To Stimulus Regulation Of Cellular Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Hydrolase Activity
Tagcloud ?		aggregation anilino ans bile bsa chaperone cyclooxygenase dithiothreitol dtt ecor1 hall heat hepatoblastoma hepg2 hydrophobic inactivates marks mount naphthalene perk prevents reduces salt stabilize sulfonate tauroursodeoxycholic tudca unfolded upr	adapt anionic cannabidiol cannabinoid cbd combinatorial endowed gbm gsc gscs id1 mes modulators pn proneural psychoactive redox regrowth renewal reprogramming resist ros slc7a11 solute sox2 taqman therapeutics xc xct
Tagcloud (Difference) ?		aggregation anilino ans bile bsa chaperone cyclooxygenase dithiothreitol dtt ecor1 hall heat hepatoblastoma hepg2 hydrophobic inactivates marks mount naphthalene perk prevents reduces salt stabilize sulfonate tauroursodeoxycholic tudca unfolded upr	adapt anionic cannabidiol cannabinoid cbd combinatorial endowed gbm gsc gscs id1 mes modulators pn proneural psychoactive redox regrowth renewal reprogramming resist ros slc7a11 solute sox2 taqman therapeutics xc xct
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