EIF2AK3 and DNAJC3

Number of citations of the paper that reports this interaction (PMID 12446838)
81

Data Source:
HPRD (in vivo, in vitro)

		EIF2AK3	DNAJC3
Gene Name		eukaryotic translation initiation factor 2-alpha kinase 3	DnaJ (Hsp40) homolog, subfamily C, member 3
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Gene Ontology Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane	Cytoplasm Endoplasmic Reticulum Lumen Smooth Endoplasmic Reticulum Membrane Endoplasmic Reticulum Sec Complex Vesicle Extracellular Vesicular Exosome
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Eukaryotic Translation Initiation Factor 2alpha Kinase Activity Protein Binding ATP Binding Enzyme Binding Protein Phosphatase Binding Identical Protein Binding	Protein Kinase Inhibitor Activity Chaperone Binding Misfolded Protein Binding
	Biological Process	Skeletal System Development Ossification Angiogenesis Chondrocyte Development Translation Protein Phosphorylation Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process ER Overload Response Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Endoplasmic Reticulum Organization Lactation Positive Regulation Vascular Endothelial Growth Factor Production Positive Regulation Of Gene Expression Regulation Of Translational Initiation By EIF2 Alpha Phosphorylation Negative Regulation Of Translation Peptidyl-serine Phosphorylation Regulation Of Fatty Acid Metabolic Process Calcium-mediated Signaling Insulin Secretion Bone Mineralization Endoplasmic Reticulum Unfolded Protein Response Endocrine Pancreas Development Negative Regulation Of Myelination Negative Regulation Of Translational Initiation In Response To Stress Positive Regulation Of Protein Binding SREBP Signaling Pathway Response To Endoplasmic Reticulum Stress Cellular Response To Glucose Starvation Negative Regulation Of Apoptotic Process Cellular Protein Metabolic Process Fat Cell Differentiation Positive Regulation Of Transcription From RNA Polymerase I Promoter Protein Autophosphorylation Insulin-like Growth Factor Receptor Signaling Pathway Protein Homooligomerization Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Positive Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway	Negative Regulation Of Protein Phosphorylation Negative Regulation Of Protein Kinase Activity Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Endoplasmic Reticulum Unfolded Protein Response Negative Regulation Of Apoptotic Process Cellular Protein Metabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Defense Response To Virus
Pathways		PERK regulates gene expression Unfolded Protein Response (UPR)	Influenza Viral RNA Transcription and Replication IRE1alpha activates chaperones Influenza Infection Viral mRNA Translation XBP1(S) activates chaperone genes Unfolded Protein Response (UPR) Influenza Life Cycle
Drugs
Diseases
GWAS		Height ( 20881960) Progressive supranuclear palsy ( 21685912)
Protein-Protein Interactions		6 interactors: DNAJC3 EIF2S1 HSP90AA1 HSPA5 IKBKB NFE2L2	6 interactors: DNAJB1 EIF2AK2 EIF2AK3 HSPA1A PRKRIR TIRAP
Entrez ID		9451	5611
HPRD ID		04942	03114
Ensembl ID		ENSG00000172071	ENSG00000102580
Uniprot IDs		B3KY45 Q9NZJ5	A8KA82 Q13217
PDB IDs		4G31 4G34	2Y4T 2Y4U
Enriched GO Terms of Interacting Partners?		Response To Unfolded Protein Endoplasmic Reticulum Unfolded Protein Response Cellular Response To Unfolded Protein ER-nucleus Signaling Pathway Cellular Response To Topologically Incorrect Protein Response To Endoplasmic Reticulum Stress Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Positive Regulation Of Nuclease Activity Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Cellular Response To Stress Positive Regulation Of Metabolic Process Response To Stress Cellular Response To Organic Substance Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Cellular Protein Metabolic Process Negative Regulation Of Cell Death Regulation Of Nitrogen Compound Metabolic Process Signal Transduction Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Protein Metabolic Process Signaling Positive Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Apoptotic Process Cell Communication Proteolysis Involved In Cellular Protein Catabolic Process Regulation Of Cell Death Positive Regulation Of Transferase Activity Regulation Of Protein Folding In Endoplasmic Reticulum Cellular Protein Catabolic Process Cellular Response To Tumor Necrosis Factor Cellular Response To Cytokine Stimulus Protein Catabolic Process Response To Tumor Necrosis Factor Response To External Stimulus Cellular Response To Stimulus Cerebellum Structural Organization Response To Cytokine Positive Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Response To Biotic Stimulus Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Kinase Activity Cellular Macromolecule Catabolic Process Positive Regulation Of Phosphorylation Protein Import Into Mitochondrial Outer Membrane Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress Proteasomal Ubiquitin-independent Protein Catabolic Process	Response To Unfolded Protein Regulation Of Translational Initiation By EIF2 Alpha Phosphorylation Posttranscriptional Regulation Of Gene Expression Negative Regulation Of Inclusion Body Assembly Regulation Of Translational Initiation In Response To Stress Regulation Of Translation In Response To Stress Regulation Of Inclusion Body Assembly Protein Refolding Response To Stress Response To Biotic Stimulus Regulation Of Cellular Response To Heat Positive Regulation Of Chemokine Production Positive Regulation Of Cytokine Production Response To Organic Substance Regulation Of Chemokine Production Cellular Response To Heat Positive Regulation Of Protein Binding Regulation Of Translational Initiation Negative Regulation Of Translation Regulation Of Cell Proliferation Endoplasmic Reticulum Unfolded Protein Response Regulation Of Cytokine Production Cellular Response To Stress Cellular Response To Unfolded Protein Evasion Or Tolerance By Virus Of Host Immune Response Positive Regulation Of Interleukin-15 Production Positive Regulation Of Chemokine (C-X-C Motif) Ligand 1 Production TIRAP-dependent Toll-like Receptor 4 Signaling Pathway Interaction With Host ER-nucleus Signaling Pathway Cellular Response To Topologically Incorrect Protein Response To Heat Positive Regulation Of Binding Positive Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Cell Proliferation Response To External Stimulus Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Cellular Response To Stimulus Positive Regulation Of Toll-like Receptor 2 Signaling Pathway Cellular Heat Acclimation Regulation Of Hematopoietic Stem Cell Differentiation Response To Other Organism Regulation Of Protein Binding Response To Endoplasmic Reticulum Stress Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Toll-like Receptor 3 Signaling Pathway Evasion Or Tolerance Of Host Defenses By Virus Negative Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Phosphorylation
Tagcloud ?		aggregation anilino ans bile bsa chaperone cyclooxygenase dithiothreitol dtt ecor1 hall heat hepatoblastoma hepg2 hydrophobic inactivates marks mount naphthalene perk prevents reduces salt stabilize sulfonate tauroursodeoxycholic tudca unfolded upr	atf4 attenuation bcl2 bip chop confirming db ddit3 ebp homologue hsp40 hspa5 immunoglobulin interpretation islet islets min6 oleate overproduction p58 palmitate pancreas secreting sections supply triggers virtually xbp1
Tagcloud (Difference) ?		aggregation anilino ans bile bsa chaperone cyclooxygenase dithiothreitol dtt ecor1 hall heat hepatoblastoma hepg2 hydrophobic inactivates marks mount naphthalene perk prevents reduces salt stabilize sulfonate tauroursodeoxycholic tudca unfolded upr	atf4 attenuation bcl2 bip chop confirming db ddit3 ebp homologue hsp40 hspa5 immunoglobulin interpretation islet islets min6 oleate overproduction p58 palmitate pancreas secreting sections supply triggers virtually xbp1
Tagcloud (Intersection) ?