EIF2AK3

Description		eukaryotic translation initiation factor 2 alpha kinase 3
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GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Membrane Mitochondria-associated Endoplasmic Reticulum Membrane Contact Site Perinuclear Region Of Cytoplasm
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Eukaryotic Translation Initiation Factor 2alpha Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Enzyme Binding Protein Phosphatase Binding Identical Protein Binding Translation Regulator Activity Misfolded Protein Binding Hsp90 Protein Binding Protein Serine Kinase Activity
	Biological Process	Skeletal System Development Ossification Angiogenesis Chondrocyte Development Translational Initiation Regulation Of Translation Regulation Of Translational Initiation Response To Oxidative Stress ER Overload Response Response To Unfolded Protein Endoplasmic Reticulum Organization Positive Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of Gene Expression Negative Regulation Of Translation Calcium-mediated Signaling Bone Mineralization Endoplasmic Reticulum Unfolded Protein Response Endocrine Pancreas Development Negative Regulation Of Myelination Negative Regulation Of Translation In Response To Stress Negative Regulation Of Translational Initiation In Response To Stress Cellular Response To Amino Acid Starvation Response To Endoplasmic Reticulum Stress Regulation Of Translation Initiation In Response To Endoplasmic Reticulum Stress PERK-mediated Unfolded Protein Response Cellular Response To Glucose Starvation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Transcription By RNA Polymerase I Negative Regulation Of Translational Initiation Insulin-like Growth Factor Receptor Signaling Pathway Cellular Response To Cold Mitochondrial Respirasome Assembly Positive Regulation Of Protein Localization To Nucleus Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Response To Manganese-induced Endoplasmic Reticulum Stress
Pathways		PERK regulates gene expression ALK mutants bind TKIs Signaling by ALK fusions and activated point mutants KEAP1-NFE2L2 pathway Modulation of host responses by IFN-stimulated genes
Drugs
Diseases		Permanent neonatal diabetes mellitus (PNDM) Wolcott-Rallison syndrome; SED, Wolcott-Rallison type
GWAS		Adverse response to drug ( 30420678) Appendicular lean mass ( 33097823) Chronotype ( 30696823) Height ( 20881960 25282103 25429064 31562340) Hip circumference adjusted for BMI ( 34021172) Progressive supranuclear palsy ( 21685912)
Interacting Genes		7 interacting genes: DNAJC3 EIF2S1 HSP90AA1 HSPA5 IKBKB NFE2L2 RNF10
Entrez ID		9451
HPRD ID		04942
Ensembl ID		ENSG00000172071
Uniprot IDs		A0A804HIT4 B3KY45 Q9NZJ5
PDB IDs		4G31 4G34 4M7I 4X7H 4X7J 4X7K 4X7L 4X7N 4X7O 4YZS 5SV7 7MF0 8EQ9 8EQD 8EQE
Enriched GO Terms of Interacting Partners?		PERK-mediated Unfolded Protein Response ER-nucleus Signaling Pathway Integrated Stress Response Signaling Response To Endoplasmic Reticulum Stress Endoplasmic Reticulum Unfolded Protein Response Cellular Response To Stress Protein Metabolic Process Regulation Of Translation In Response To Endoplasmic Reticulum Stress Regulation Of Translational Initiation In Response To Stress Protein Folding In Endoplasmic Reticulum Misfolded Protein Binding Response To Temperature Stimulus Regulation Of Translation In Response To Stress Cellular Response To Starvation Protein Catabolic Process Protein Refolding Protein Folding Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Response To Starvation Positive Regulation Of Biosynthetic Process Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Macromolecule Biosynthetic Process ATP-dependent Protein Folding Chaperone Regulation Of Protein Metabolic Process Regulation Of Gene Expression Cellular Response To Nutrient Levels Response To Cold Regulation Of Macromolecule Biosynthetic Process Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Protein Metabolic Process Cellular Response To Glucose Starvation Cellular Response To Heat Ubiquitin Protein Ligase Binding Intracellular Signaling Cassette Response To Stress Positive Regulation Of Macromolecule Metabolic Process Protein Folding Chaperone Translation Initiation Ternary Complex Regulation Of Macromolecule Metabolic Process Ribosome Binding Catabolic Process Protein Transmembrane Transport Macromolecule Catabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Protein Folding In Endoplasmic Reticulum Response To Virus CTP Binding
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