EIF2AK3

Gene Name		eukaryotic translation initiation factor 2-alpha kinase 3
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Gene Ontology Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Eukaryotic Translation Initiation Factor 2alpha Kinase Activity Protein Binding ATP Binding Enzyme Binding Protein Phosphatase Binding Identical Protein Binding
	Biological Process	Skeletal System Development Ossification Angiogenesis Chondrocyte Development Translation Protein Phosphorylation Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process ER Overload Response Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Endoplasmic Reticulum Organization Lactation Positive Regulation Vascular Endothelial Growth Factor Production Positive Regulation Of Gene Expression Regulation Of Translational Initiation By EIF2 Alpha Phosphorylation Negative Regulation Of Translation Peptidyl-serine Phosphorylation Regulation Of Fatty Acid Metabolic Process Calcium-mediated Signaling Insulin Secretion Bone Mineralization Endoplasmic Reticulum Unfolded Protein Response Endocrine Pancreas Development Negative Regulation Of Myelination Negative Regulation Of Translational Initiation In Response To Stress Positive Regulation Of Protein Binding SREBP Signaling Pathway Response To Endoplasmic Reticulum Stress Cellular Response To Glucose Starvation Negative Regulation Of Apoptotic Process Cellular Protein Metabolic Process Fat Cell Differentiation Positive Regulation Of Transcription From RNA Polymerase I Promoter Protein Autophosphorylation Insulin-like Growth Factor Receptor Signaling Pathway Protein Homooligomerization Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Positive Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway
Pathways		PERK regulates gene expression Unfolded Protein Response (UPR)
Drugs
Diseases
GWAS		Height ( 20881960) Progressive supranuclear palsy ( 21685912)
Protein-protein Interactions		6 interactors: DNAJC3 EIF2S1 HSP90AA1 HSPA5 IKBKB NFE2L2
Entrez ID		9451
HPRD ID		04942
Ensembl ID		ENSG00000172071
Uniprot IDs		B3KY45 Q9NZJ5
PDB IDs		4G31 4G34
Enriched GO Terms of Interacting Partners?		Response To Unfolded Protein Endoplasmic Reticulum Unfolded Protein Response Cellular Response To Unfolded Protein ER-nucleus Signaling Pathway Cellular Response To Topologically Incorrect Protein Response To Endoplasmic Reticulum Stress Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Positive Regulation Of Nuclease Activity Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Cellular Response To Stress Positive Regulation Of Metabolic Process Response To Stress Cellular Response To Organic Substance Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Cellular Protein Metabolic Process Negative Regulation Of Cell Death Regulation Of Nitrogen Compound Metabolic Process Signal Transduction Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Protein Metabolic Process Signaling Positive Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Apoptotic Process Cell Communication Proteolysis Involved In Cellular Protein Catabolic Process Regulation Of Cell Death Positive Regulation Of Transferase Activity Regulation Of Protein Folding In Endoplasmic Reticulum Cellular Protein Catabolic Process Cellular Response To Tumor Necrosis Factor Cellular Response To Cytokine Stimulus Protein Catabolic Process Response To Tumor Necrosis Factor Response To External Stimulus Cellular Response To Stimulus Cerebellum Structural Organization Response To Cytokine Positive Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Response To Biotic Stimulus Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Kinase Activity Cellular Macromolecule Catabolic Process Positive Regulation Of Phosphorylation Protein Import Into Mitochondrial Outer Membrane Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress Proteasomal Ubiquitin-independent Protein Catabolic Process
Tagcloud ?		aggregation anilino ans bile bsa chaperone cyclooxygenase dithiothreitol dtt ecor1 hall heat hepatoblastoma hepg2 hydrophobic inactivates marks mount naphthalene perk prevents reduces salt stabilize sulfonate tauroursodeoxycholic tudca unfolded upr