EIF2AK3 and EIF2S1

Number of citations of the paper that reports this interaction (PubMedID 9819435)
53

Data Source:
HPRD (in vitro, in vivo)

		EIF2AK3	EIF2S1
Description		eukaryotic translation initiation factor 2 alpha kinase 3	eukaryotic translation initiation factor 2 subunit alpha
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GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Membrane Mitochondria-associated Endoplasmic Reticulum Membrane Contact Site Perinuclear Region Of Cytoplasm	Nucleus Cytoplasm Mitochondrion Cytosol Eukaryotic Translation Initiation Factor 2 Complex Cytoplasmic Stress Granule Membrane Eukaryotic 48S Preinitiation Complex Translation Initiation Ternary Complex Synapse Extracellular Exosome Glial Limiting End-foot
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Eukaryotic Translation Initiation Factor 2alpha Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Enzyme Binding Protein Phosphatase Binding Identical Protein Binding Translation Regulator Activity Misfolded Protein Binding Hsp90 Protein Binding Protein Serine Kinase Activity	Nucleic Acid Binding RNA Binding Translation Initiation Factor Activity Protein Binding Ribosome Binding
	Biological Process	Skeletal System Development Ossification Angiogenesis Chondrocyte Development Translational Initiation Regulation Of Translation Regulation Of Translational Initiation Response To Oxidative Stress ER Overload Response Response To Unfolded Protein Endoplasmic Reticulum Organization Positive Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of Gene Expression Negative Regulation Of Translation Calcium-mediated Signaling Bone Mineralization Endoplasmic Reticulum Unfolded Protein Response Endocrine Pancreas Development Negative Regulation Of Myelination Negative Regulation Of Translation In Response To Stress Negative Regulation Of Translational Initiation In Response To Stress Cellular Response To Amino Acid Starvation Response To Endoplasmic Reticulum Stress Regulation Of Translation Initiation In Response To Endoplasmic Reticulum Stress PERK-mediated Unfolded Protein Response Cellular Response To Glucose Starvation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Transcription By RNA Polymerase I Negative Regulation Of Translational Initiation Insulin-like Growth Factor Receptor Signaling Pathway Cellular Response To Cold Mitochondrial Respirasome Assembly Positive Regulation Of Protein Localization To Nucleus Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Response To Manganese-induced Endoplasmic Reticulum Stress	Mitophagy Translation Translational Initiation Regulation Of Translation Negative Regulation Of Translational Initiation In Response To Stress Stress Granule Assembly Cellular Response To Amino Acid Starvation Cellular Response To Oxidative Stress Cellular Response To Heat Cellular Response To UV Response To Endoplasmic Reticulum Stress Regulation Of Translation In Response To Endoplasmic Reticulum Stress PERK-mediated Unfolded Protein Response Regulation Of Translational Initiation In Response To Stress Mitochondrial Respirasome Assembly HRI-mediated Signaling Response To Kainic Acid Response To Manganese-induced Endoplasmic Reticulum Stress Positive Regulation Of Type B Pancreatic Cell Apoptotic Process
Pathways		PERK regulates gene expression ALK mutants bind TKIs Signaling by ALK fusions and activated point mutants KEAP1-NFE2L2 pathway Modulation of host responses by IFN-stimulated genes	L13a-mediated translational silencing of Ceruloplasmin expression PERK regulates gene expression PERK regulates gene expression ABC-family proteins mediated transport Translation initiation complex formation Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit Recycling of eIF2:GDP Response of EIF2AK4 (GCN2) to amino acid deficiency Response of EIF2AK1 (HRI) to heme deficiency PKR-mediated signaling Cellular response to mitochondrial stress
Drugs
Diseases		Permanent neonatal diabetes mellitus (PNDM) Wolcott-Rallison syndrome; SED, Wolcott-Rallison type
GWAS		Adverse response to drug ( 30420678) Appendicular lean mass ( 33097823) Chronotype ( 30696823) Height ( 20881960 25282103 25429064 31562340) Hip circumference adjusted for BMI ( 34021172) Progressive supranuclear palsy ( 21685912)
Interacting Genes		7 interacting genes: DNAJC3 EIF2S1 HSP90AA1 HSPA5 IKBKB NFE2L2 RNF10	28 interacting genes: ACTN1 ANXA1 CASP3 CASP6 CDC37 CEBPA CSNK2A1 EIF1AX EIF2AK1 EIF2AK2 EIF2AK3 EIF2B1 EIF2B2 EIF2B3 EIF2B4 EIF2S2 HSP90AA1 HSPB1 MELK P4HB PPP1R15A PRKCA PRKCD PRMT7 SFN TERT THAP12 VAC14
Entrez ID		9451	1965
HPRD ID		04942	04881
Ensembl ID		ENSG00000172071	ENSG00000134001
Uniprot IDs		A0A804HIT4 B3KY45 Q9NZJ5	P05198 Q53XC0
PDB IDs		4G31 4G34 4M7I 4X7H 4X7J 4X7K 4X7L 4X7N 4X7O 4YZS 5SV7 7MF0 8EQ9 8EQD 8EQE	1KL9 1Q8K 6K71 6K72 6O81 6O85 6O9Z 6YBV 6ZMW 6ZP4 7A09 7D43 7D44 7D45 7F66 7F67 7NZM 7QP6 7QP7 7SYR 7SYS 8OZ0 8PJ1 8PJ2 8PJ3 8PJ4 8PPL 8QZZ
Enriched GO Terms of Interacting Partners?		PERK-mediated Unfolded Protein Response ER-nucleus Signaling Pathway Integrated Stress Response Signaling Response To Endoplasmic Reticulum Stress Endoplasmic Reticulum Unfolded Protein Response Cellular Response To Stress Protein Metabolic Process Regulation Of Translation In Response To Endoplasmic Reticulum Stress Regulation Of Translational Initiation In Response To Stress Protein Folding In Endoplasmic Reticulum Misfolded Protein Binding Response To Temperature Stimulus Regulation Of Translation In Response To Stress Cellular Response To Starvation Protein Catabolic Process Protein Refolding Protein Folding Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Response To Starvation Positive Regulation Of Biosynthetic Process Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Macromolecule Biosynthetic Process ATP-dependent Protein Folding Chaperone Regulation Of Protein Metabolic Process Regulation Of Gene Expression Cellular Response To Nutrient Levels Response To Cold Regulation Of Macromolecule Biosynthetic Process Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Protein Metabolic Process Cellular Response To Glucose Starvation Cellular Response To Heat Ubiquitin Protein Ligase Binding Intracellular Signaling Cassette Response To Stress Positive Regulation Of Macromolecule Metabolic Process Protein Folding Chaperone Translation Initiation Ternary Complex Regulation Of Macromolecule Metabolic Process Ribosome Binding Catabolic Process Protein Transmembrane Transport Macromolecule Catabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Protein Folding In Endoplasmic Reticulum Response To Virus CTP Binding	Translational Initiation Eukaryotic Translation Initiation Factor 2B Complex Translation Initiation Factor Activity Cytosol Regulation Of Translational Initiation Response To Stress Post-transcriptional Regulation Of Gene Expression Cytoplasmic Translational Initiation Protein Metabolic Process Response To Temperature Stimulus Response To Heat Regulation Of Apoptotic Process Regulation Of Translation Regulation Of Programmed Cell Death Eukaryotic Translation Initiation Factor 2alpha Kinase Activity Regulation Of Protein Metabolic Process Response To Hormone Regulation Of Immune System Process Signal Transduction Oligodendrocyte Development Positive Regulation Of Immune System Process Intrinsic Apoptotic Signaling Pathway Macromolecule Metabolic Process Apoptotic Signaling Pathway Translation Protein Serine Kinase Activity Regulation Of Immune Response Intracellular Signal Transduction Response To Glucose Cellular Response To Stress Response To Monosaccharide Protein Serine/threonine Kinase Activity Glial Cell Development Activation Of Immune Response Translation Factor Activity, RNA Binding Response To Carbohydrate Cell Development Protein Kinase C Inhibitor Activity Positive Regulation Of Immune Response Identical Protein Binding Response To Peptide Hormone Cytoplasm Regulation Of Gene Expression Regulation Of Stem Cell Proliferation Negative Regulation Of Translation Protein Kinase Activity Regulation Of Macromolecule Biosynthetic Process Cellular Response To Staurosporine Protein Kinase C Signaling Protein Folding
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