SLC9A1 and CHP1

Number of citations of the paper that reports this interaction (PubMedID 8901634)
41

Data Source:
HPRD (in vivo, in vitro)

		SLC9A1	CHP1
Description		solute carrier family 9 member A1	calcineurin like EF-hand protein 1
Image
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion Plasma Membrane Focal Adhesion Cell Surface Intercalated Disc Membrane Basolateral Plasma Membrane Apical Plasma Membrane Lamellipodium T-tubule Sarcolemma Membrane Raft Perinuclear Region Of Cytoplasm Extracellular Exosome Cation-transporting ATPase Complex Transporter Complex	Golgi Membrane Nucleus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum-Golgi Intermediate Compartment Cytoskeleton Plasma Membrane Focal Adhesion Endomembrane System Microtubule Cytoskeleton Membrane Transport Vesicle Membrane Raft Extracellular Exosome Transporter Complex
	Molecular Function	Protein Binding Calmodulin Binding Phospholipid Binding Phosphatidylinositol-4,5-bisphosphate Binding Antiporter Activity Sodium:proton Antiporter Activity Potassium:proton Antiporter Activity Protein Phosphatase 2B Binding Protein-macromolecule Adaptor Activity Identical Protein Binding Calcium-dependent Protein Binding Molecular Adaptor Activity	Protein Kinase Inhibitor Activity Calcium Ion Binding Protein Binding Microtubule Binding Sodium:proton Antiporter Activity Potassium Channel Regulator Activity Kinase Binding Metal Ion Binding Calcium-dependent Protein Binding
	Biological Process	Regulation Of The Force Of Heart Contraction Monoatomic Ion Transport Monoatomic Cation Transport Sodium Ion Transport Intracellular Sodium Ion Homeostasis Regulation Of PH Response To Acidic PH Positive Regulation Of Cardiac Muscle Hypertrophy Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Cell Migration Maintenance Of Cell Polarity Cell Differentiation Positive Regulation Of Cell Growth Cellular Response To Insulin Stimulus Positive Regulation Of Mitochondrial Membrane Permeability Response To Muscle Stretch Sodium Ion Export Across Plasma Membrane Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Action Potential Positive Regulation Of Transcription By RNA Polymerase II Stem Cell Differentiation Protein Complex Oligomerization Regulation Of Intracellular PH Regulation Of Stress Fiber Assembly Regulation Of Focal Adhesion Assembly Cardiac Muscle Cell Differentiation Transmembrane Transport Cellular Response To Cold Positive Regulation Of Calcineurin-NFAT Signaling Cascade Cellular Response To Antibiotic Cellular Response To Electrical Stimulus Cellular Response To Mechanical Stimulus Cellular Response To Hypoxia Cellular Response To Acidic PH Potassium Ion Transmembrane Transport Cellular Response To Epinephrine Stimulus Cardiac Muscle Cell Contraction Regulation Of Cardiac Muscle Cell Membrane Potential Regulation Of The Force Of Heart Contraction By Cardiac Conduction Sodium Ion Import Across Plasma Membrane Positive Regulation Of The Force Of Heart Contraction Positive Regulation Of Intracellular Signal Transduction Proton Transmembrane Transport	Microtubule Bundle Formation Negative Regulation Of Protein Phosphorylation Negative Regulation Of Protein Kinase Activity Protein Export From Nucleus Potassium Ion Transport Small GTPase-mediated Signal Transduction Negative Regulation Of Phosphatase Activity Protein Transport Membrane Docking Cytoplasmic Microtubule Organization Negative Regulation Of Protein Ubiquitination Negative Regulation Of Protein Autophosphorylation Negative Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Sodium:proton Antiporter Activity Sodium Ion Transmembrane Transport Regulation Of Protein Import Into Nucleus Negative Regulation Of Protein Import Into Nucleus Protein Stabilization Positive Regulation Of Protein Transport Regulation Of Intracellular PH Positive Regulation Of Protein Glycosylation Membrane Organization Membrane Fusion Regulation Of Calcineurin-NFAT Signaling Cascade Negative Regulation Of Calcineurin-NFAT Signaling Cascade Positive Regulation Of Phospholipid Biosynthetic Process Cellular Response To Acidic PH Positive Regulation Of Protein Targeting To Membrane
Pathways		Hyaluronan degradation Sodium/Proton exchangers	Hyaluronan degradation
Drugs		Amiloride Homoserine Lactone Cariporide	Calcium citrate Calcium Phosphate Calcium phosphate dihydrate
Diseases
GWAS		Lateral ventricle volume ( 31530798)	Allergic disease (asthma, hay fever or eczema) ( 29785011) Essential hypertension (time to event) ( 32589924) Estimated glomerular filtration rate ( 31015462) Ulcerative colitis ( 28067908) White blood cell count ( 32888494)
Interacting Genes		12 interacting genes: CA2 CHP1 CHP2 DAXX MAP3K14 MAP4K4 MAPK1 MAPK14 MDFI TESC WNK1 YWHAB	10 interacting genes: GAPDH KIF1B PRSS23 SLC9A1 SLC9A2 SLC9A3 SLC9A4 SLC9A5 STK17B UBC
Entrez ID		6548	11261
HPRD ID		00123	06101
Ensembl ID		ENSG00000090020	ENSG00000187446
Uniprot IDs		B2RAH2 P19634	H0YKE7 Q99653
PDB IDs		1Y4E 2BEC 2E30 2HTG 2KBV 2L0E 2MDF 2YGG 6BJF 6NUC 6NUF 6NUU 6ZBI 7DSV 7DSW 7DSX	2E30 7DSV 7DSX 7X2U
Enriched GO Terms of Interacting Partners?		Regulation Of Nucleocytoplasmic Transport Regulation Of Intracellular Transport Regulation Of Protein Import Into Nucleus Regulation Of Protein Localization To Nucleus Protein Serine Kinase Activity Protein Serine/threonine Kinase Activity MAPK Cascade Positive Regulation Of Sodium:proton Antiporter Activity Protein Kinase Activity Regulation Of Cellular Localization Intracellular Signaling Cassette Regulation Of Calcineurin-NFAT Signaling Cascade Regulation Of Calcineurin-mediated Signaling Regulation Of Sodium Ion Transmembrane Transport Regulation Of Intracellular Protein Transport Protein Kinase Inhibitor Activity Kinase Activity Negative Regulation Of Protein Localization To Nucleus Positive Regulation Of Sodium Ion Transmembrane Transporter Activity Regulation Of Transport Regulation Of Phosphatase Activity Regulation Of Sodium Ion Transport Negative Regulation Of Protein Localization Positive Regulation Of Keratinocyte Migration Intracellular Signal Transduction Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Cellular PH Positive Regulation Of Myotube Differentiation Regulation Of Protein Localization Negative Regulation Of Calcineurin-NFAT Signaling Cascade Regulation Of Calcium-mediated Signaling Regulation Of PH Positive Regulation Of Cell Migration MAP Kinase Activity Positive Regulation Of Lipid Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Cell Motility Regulation Of Intracellular Signal Transduction Positive Regulation Of Sodium Ion Transmembrane Transport Positive Regulation Of Biosynthetic Process Negative Regulation Of Protein Import Into Nucleus Regulation Of RNA Metabolic Process Positive Regulation Of Locomotion Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Phosphate Metabolic Process Pyrimidine Nucleobase Metabolic Process Negative Regulation Of Calcium-mediated Signaling Stress-activated MAPK Cascade	Sodium:proton Antiporter Activity Potassium:proton Antiporter Activity Sodium Ion Import Across Plasma Membrane Regulation Of Cellular PH Regulation Of Intracellular PH Antiporter Activity Inorganic Cation Import Across Plasma Membrane Regulation Of PH Sodium Ion Transmembrane Transport Import Across Plasma Membrane Potassium Ion Transmembrane Transport Proton Transmembrane Transport Potassium Ion Transport Sodium Ion Transport Intracellular Monoatomic Cation Homeostasis Intracellular Monoatomic Ion Homeostasis Monoatomic Cation Homeostasis Monoatomic Ion Homeostasis Intracellular Chemical Homeostasis Metal Ion Transport Import Into Cell Monoatomic Cation Transmembrane Transport Inorganic Cation Transmembrane Transport Cellular Homeostasis Inorganic Ion Transmembrane Transport Monoatomic Cation Transport Monoatomic Ion Transmembrane Transport Apical Plasma Membrane Chemical Homeostasis Monoatomic Ion Transport Transmembrane Transport Homeostatic Process Plasma Membrane Peptidyl-cysteine S-trans-nitrosylation Glyceraldehyde-3-phosphate Dehydrogenase (NAD+) (phosphorylating) Activity Regulation Of The Force Of Heart Contraction By Cardiac Conduction Cation-transporting ATPase Complex Regulation Of Biological Quality Recycling Endosome Membrane Membrane Peptidyl-cysteine S-nitrosylase Activity Peptidyl-cysteine S-nitrosylation GAIT Complex Transporter Complex Transepithelial Ammonium Transport Positive Regulation Of The Force Of Heart Contraction Retrograde Neuronal Dense Core Vesicle Transport Glandular Epithelial Cell Development Extracellular Exosome Aspartic-type Endopeptidase Inhibitor Activity
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