SLC9A1 and DAXX

Number of citations of the paper that reports this interaction (PubMedID 18003619)
0

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		SLC9A1	DAXX
Description		solute carrier family 9 member A1	death domain associated protein
Image
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion Plasma Membrane Focal Adhesion Cell Surface Intercalated Disc Membrane Basolateral Plasma Membrane Apical Plasma Membrane Lamellipodium T-tubule Sarcolemma Membrane Raft Perinuclear Region Of Cytoplasm Extracellular Exosome Cation-transporting ATPase Complex Transporter Complex	Chromosome, Centromeric Region Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm Cytosol Nuclear Body PML Body
	Molecular Function	Protein Binding Calmodulin Binding Phospholipid Binding Phosphatidylinositol-4,5-bisphosphate Binding Antiporter Activity Sodium:proton Antiporter Activity Potassium:proton Antiporter Activity Protein Phosphatase 2B Binding Protein-macromolecule Adaptor Activity Identical Protein Binding Calcium-dependent Protein Binding Molecular Adaptor Activity	P53 Binding Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Enzyme Binding Protein Kinase Binding Protein Kinase Activator Activity Heat Shock Protein Binding Ubiquitin Protein Ligase Binding Histone Binding Protein Homodimerization Activity Nuclear Androgen Receptor Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Transcription Regulator Inhibitor Activity Molecular Condensate Scaffold Activity
	Biological Process	Regulation Of The Force Of Heart Contraction Monoatomic Ion Transport Monoatomic Cation Transport Sodium Ion Transport Intracellular Sodium Ion Homeostasis Regulation Of PH Response To Acidic PH Positive Regulation Of Cardiac Muscle Hypertrophy Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Cell Migration Maintenance Of Cell Polarity Cell Differentiation Positive Regulation Of Cell Growth Cellular Response To Insulin Stimulus Positive Regulation Of Mitochondrial Membrane Permeability Response To Muscle Stretch Sodium Ion Export Across Plasma Membrane Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Action Potential Positive Regulation Of Transcription By RNA Polymerase II Stem Cell Differentiation Protein Complex Oligomerization Regulation Of Intracellular PH Regulation Of Stress Fiber Assembly Regulation Of Focal Adhesion Assembly Cardiac Muscle Cell Differentiation Transmembrane Transport Cellular Response To Cold Positive Regulation Of Calcineurin-NFAT Signaling Cascade Cellular Response To Antibiotic Cellular Response To Electrical Stimulus Cellular Response To Mechanical Stimulus Cellular Response To Hypoxia Cellular Response To Acidic PH Potassium Ion Transmembrane Transport Cellular Response To Epinephrine Stimulus Cardiac Muscle Cell Contraction Regulation Of Cardiac Muscle Cell Membrane Potential Regulation Of The Force Of Heart Contraction By Cardiac Conduction Sodium Ion Import Across Plasma Membrane Positive Regulation Of The Force Of Heart Contraction Positive Regulation Of Intracellular Signal Transduction Proton Transmembrane Transport	Chromatin Organization Nucleosome Assembly Chromatin Remodeling Regulation Of DNA-templated Transcription Apoptotic Process JNK Cascade Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Gene Expression Negative Regulation Of Gene Expression Androgen Receptor Signaling Pathway Regulation Of Protein Ubiquitination Cellular Response To Heat Cellular Response To Unfolded Protein Neuron Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Regulation Of Apoptotic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Cellular Response To Cadmium Ion Cellular Response To Copper Ion Cellular Response To Diamide Cellular Response To Sodium Arsenite
Pathways		Hyaluronan degradation Sodium/Proton exchangers	SUMOylation of transcription cofactors Regulation of TP53 Degradation HCMV Early Events Inhibition of DNA recombination at telomere Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations
Drugs		Amiloride Homoserine Lactone Cariporide
Diseases
GWAS		Lateral ventricle volume ( 31530798)	Adult body size ( 32376654) Autism spectrum disorder or schizophrenia ( 28540026) Disrupted circadian rhythm (low relative amplitude of rest-activity cycles) ( 30120083) Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730)
Interacting Genes		12 interacting genes: CA2 CHP1 CHP2 DAXX MAP3K14 MAP4K4 MAPK1 MAPK14 MDFI TESC WNK1 YWHAB	114 interacting genes: ACVR2A AIRE AMOTL2 AR ATM ATRX BTBD6 CA12 CALCOCO2 CARD9 CARM1 CBS CDCA7L CENPC CEP63 CEP70 CFLAR CREBBP CSNK2A1 CSNK2B DAPK3 DKC1 DMAP1 DNMT1 DRC4 ESRRG ETS1 FAM9B FANCA FAS FASLG FTH1 GOLGA2 GOLGA6L9 GRIPAP1 H3-3B H3-5 H3C3 H4C16 HABP4 HBA1 HDAC1 HDAC2 HDAC3 HIPK1 HIPK2 HIPK3 HSF1 HSF4 HSPB1 KCTD4 MAP3K5 MCRS1 MDM2 MEN1 MIPOL1 MKRN1 MSANTD4 MX1 MYH11 NECAB2 NSD3 PARK7 PAX3 PAX5 PBXIP1 PIBF1 PLAGL1 PML PNMA1 PRMT1 PTEN RASSF1 RASSF3 RIPK3 RNF4 RPL13 SENP2 SERBP1 SLC2A4 SLC9A1 SNW1 SPN SPOP SQSTM1 SSX2IP STAT3 STK4 STUB1 SUMO1 SUMO2 SUMO3 TAX1BP1 TCF3 TCF4 TCF7L2 TFIP11 TGFB1 TGFBR2 TNFRSF1A TP53 TP63 TP73 TRAF3 TRIM21 TRIM54 TSG101 UBC UBE2I USH1G USP7 WEE2-AS1 ZBTB2 ZBTB26
Entrez ID		6548	1616
HPRD ID		00123	04424
Ensembl ID		ENSG00000090020	ENSG00000204209
Uniprot IDs		B2RAH2 P19634	A0A024RCS3 B4E1C1 Q53F85 Q9UER7
PDB IDs		1Y4E 2BEC 2E30 2HTG 2KBV 2L0E 2MDF 2YGG 6BJF 6NUC 6NUF 6NUU 6ZBI 7DSV 7DSW 7DSX	2KQS 2KZS 2KZU 4H9N 4H9O 4H9P 4H9Q 4H9R 4H9S 4HGA 5GRQ 5KDM 5Y18 5Y6O
Enriched GO Terms of Interacting Partners?		Regulation Of Nucleocytoplasmic Transport Regulation Of Intracellular Transport Regulation Of Protein Import Into Nucleus Regulation Of Protein Localization To Nucleus Protein Serine Kinase Activity Protein Serine/threonine Kinase Activity MAPK Cascade Positive Regulation Of Sodium:proton Antiporter Activity Protein Kinase Activity Regulation Of Cellular Localization Intracellular Signaling Cassette Regulation Of Calcineurin-NFAT Signaling Cascade Regulation Of Calcineurin-mediated Signaling Regulation Of Sodium Ion Transmembrane Transport Regulation Of Intracellular Protein Transport Protein Kinase Inhibitor Activity Kinase Activity Negative Regulation Of Protein Localization To Nucleus Positive Regulation Of Sodium Ion Transmembrane Transporter Activity Regulation Of Transport Regulation Of Phosphatase Activity Regulation Of Sodium Ion Transport Negative Regulation Of Protein Localization Positive Regulation Of Keratinocyte Migration Intracellular Signal Transduction Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Cellular PH Positive Regulation Of Myotube Differentiation Regulation Of Protein Localization Negative Regulation Of Calcineurin-NFAT Signaling Cascade Regulation Of Calcium-mediated Signaling Regulation Of PH Positive Regulation Of Cell Migration MAP Kinase Activity Positive Regulation Of Lipid Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Cell Motility Regulation Of Intracellular Signal Transduction Positive Regulation Of Sodium Ion Transmembrane Transport Positive Regulation Of Biosynthetic Process Negative Regulation Of Protein Import Into Nucleus Regulation Of RNA Metabolic Process Positive Regulation Of Locomotion Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Phosphate Metabolic Process Pyrimidine Nucleobase Metabolic Process Negative Regulation Of Calcium-mediated Signaling Stress-activated MAPK Cascade	PML Body Identical Protein Binding Nucleus Nucleoplasm Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Cellular Response To Stress Positive Regulation Of Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of DNA-templated Transcription Regulation Of Macromolecule Metabolic Process Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription DNA Damage Response Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Regulation Of Programmed Cell Death Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Metabolic Process Negative Regulation Of Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Apoptotic Signaling Pathway Regulation Of Signal Transduction Regulation Of Macromolecule Biosynthetic Process Regulation Of Apoptotic Process Regulation Of Protein Metabolic Process PML Body Organization Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Transcription By RNA Polymerase II Nuclear Body Regulation Of Gene Expression Macromolecule Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Intracellular Signal Transduction Apoptotic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Regulation Of Signaling Positive Regulation Of Programmed Cell Death Regulation Of Cell Communication Positive Regulation Of Intracellular Signal Transduction Programmed Cell Death
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