SLC9A1 and CA2

Number of citations of the paper that reports this interaction (PMID 12138085)
31

Data Source:
BioGRID (pull down, affinity chromatography technology)
HPRD (in vitro, in vivo)

		SLC9A1	CA2
Gene Name		solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1	carbonic anhydrase II
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Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Cell Surface Intercalated Disc Integral Component Of Membrane Basolateral Plasma Membrane Apical Plasma Membrane Lamellipodium T-tubule Membrane Raft Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome Cation-transporting ATPase Complex	Extracellular Space Cytoplasm Cytosol Plasma Membrane Microvillus Basolateral Plasma Membrane Axon Myelin Sheath Apical Part Of Cell Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Calmodulin Binding Phosphatidylinositol-4,5-bisphosphate Binding Solute:proton Antiporter Activity Sodium:proton Antiporter Activity Protein Phosphatase 2B Binding Protein Binding, Bridging Protein Complex Scaffold Calcium-dependent Protein Binding Sodium:proton Antiporter Activity Involved In Regulation Of Cardiac Muscle Cell Membrane Potential	Carbonate Dehydratase Activity Protein Binding Zinc Ion Binding
	Biological Process	Carbohydrate Metabolic Process Ion Transport Cellular Sodium Ion Homeostasis Regulation Of PH Pathogenesis Response To Acidic PH Positive Regulation Of Cardiac Muscle Hypertrophy Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Cell Growth Cell Migration Maintenance Of Cell Polarity Glycosaminoglycan Metabolic Process Hyaluronan Metabolic Process Hyaluronan Catabolic Process Positive Regulation Of Cell Growth Cellular Response To Insulin Stimulus Positive Regulation Of Mitochondrial Membrane Permeability Response To Muscle Stretch Response To Drug Negative Regulation Of Apoptotic Process Small Molecule Metabolic Process Positive Regulation Of Action Potential Positive Regulation Of Transcription From RNA Polymerase II Promoter Protein Oligomerization Regulation Of Intracellular PH Regulation Of Stress Fiber Assembly Positive Regulation Of NFAT Protein Import Into Nucleus Regulation Of Focal Adhesion Assembly Regulation Of Sensory Perception Of Pain Cardiac Muscle Cell Differentiation Transmembrane Transport Positive Regulation Of Calcineurin-NFAT Signaling Cascade Neuron Death Cellular Response To Antibiotic Cellular Response To Electrical Stimulus Cellular Response To Mechanical Stimulus Sodium Ion Export Cellular Response To Hypoxia Cellular Response To Acidic PH Cellular Response To Epinephrine Stimulus Cardiac Muscle Cell Contraction Regulation Of Cardiac Muscle Cell Membrane Potential Regulation Of The Force Of Heart Contraction By Cardiac Conduction Sodium Ion Import Across Plasma Membrane Positive Regulation Of The Force Of Heart Contraction Hydrogen Ion Transmembrane Transport Positive Regulation Of Calcium:sodium Antiporter Activity	Kidney Development Morphogenesis Of An Epithelium One-carbon Metabolic Process Response To PH Response To Zinc Ion Bicarbonate Transport Positive Regulation Of Synaptic Transmission, GABAergic Positive Regulation Of Cellular PH Reduction Angiotensin-activated Signaling Pathway Odontogenesis Of Dentin-containing Tooth Response To Estrogen Regulation Of Anion Transport Small Molecule Metabolic Process Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Bone Resorption Secretion Regulation Of Intracellular PH Cellular Response To Fluid Shear Stress Positive Regulation Of Dipeptide Transmembrane Transport Regulation Of Chloride Transport
Pathways		MPS IIIB - Sanfilippo syndrome B Diseases of glycosylation Defective B4GALT7 causes EDS, progeroid type MPS I - Hurler syndrome MPS IX - Natowicz syndrome Transport of inorganic cations/anions and amino acids/oligopeptides Defective SLC26A2 causes chondrodysplasias Glycosaminoglycan metabolism SLC-mediated transmembrane transport Hyaluronan uptake and degradation Defective CHST14 causes EDS, musculocontractural type Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective PAPSS2 causes SEMD-PA MPS IIIA - Sanfilippo syndrome A Myoclonic epilepsy of Lafora Glycogen storage diseases Hyaluronan metabolism MPS IIID - Sanfilippo syndrome D Defective CHST6 causes MCDC1 MPS IIIC - Sanfilippo syndrome C Diseases associated with glycosaminoglycan metabolism Sodium/Proton exchangers Mucopolysaccharidoses Defective EXT2 causes exostoses 2 MPS II - Hunter syndrome Defective CHST3 causes SEDCJD Defective B3GAT3 causes JDSSDHD Defective EXT1 causes exostoses 1, TRPS2 and CHDS MPS IV - Morquio syndrome A MPS IV - Morquio syndrome B Defective CHSY1 causes TPBS MPS VII - Sly syndrome Metabolism of carbohydrates MPS VI - Maroteaux-Lamy syndrome	O2/CO2 exchange in erythrocytes Erythrocytes take up carbon dioxide and release oxygen Erythrocytes take up oxygen and release carbon dioxide Reversible hydration of carbon dioxide
Drugs		Amiloride Homoserine Lactone	Methyclothiazide Topiramate Ethoxzolamide Bendroflumethiazide Benzthiazide Cyclothiazide Furosemide Methazolamide Hydroflumethiazide Acetazolamide Dorzolamide Chlorothiazide Zonisamide Hydrochlorothiazide Trichlormethiazide Ethinamate Diazoxide Dichlorphenamide Brinzolamide Quinethazone 4-(Hydroxymercury)Benzoic Acid N-Benzyl-4-Sulfamoyl-Benzamide 4-Flourobenzenesulfonamide Formic Acid AL5424 N-(2-Flouro-Benzyl)-4-Sulfamoyl-Benzamide 3,5-Difluorobenzenesulfonamide Al7089a 4-(Aminosulfonyl)-N-[(2,4,6-Trifluorophenyl)Methyl]-Benzamide 6-Oxo-8,9,10,11-Tetrahydro-7h-Cyclohepta[C][1]Benzopyran-3-O-Sulfamate 4-(Aminosulfonyl)-N-[(4-Fluorophenyl)Methyl]-Benzamide (R)-N-(3-Indol-1-Yl-2-Methyl-Propyl)-4-Sulfamoyl-Benzamide Aminodi(Ethyloxy)Ethylaminocarbonylbenzenesulfonamide AL7182 N-(2,3,4,5,6-Pentaflouro-Benzyl)-4-Sulfamoyl-Benzamide Cyanamide 4-(Aminosulfonyl)-N-[(3,4,5-Trifluorophenyl)Methyl]-Benzamide Dansylamide Sulfamic Acid 2,3-O-(1-Methylethylidene)-4,5-O-Sulfonyl-Beta-Fructopyranose Ester N-(2-Thienylmethyl)-2,5-Thiophenedisulfonamide 4-(Aminosulfonyl)-N-[(2,5-Difluorophenyl)Methyl]-Benzamide AL7099A Al-6619, [2h-Thieno[3,2-E]-1,2-Thiazine-6-Sulfonamide,2-(3-Hydroxyphenyl)-3-(4-Morpholinyl)-, 1,1-Dioxide] 2,6-Difluorobenzenesulfonamide 1-Methyl-3-Oxo-1,3-Dihydro-Benzo[C]Isothiazole-5-Sulfonic Acid Amide (4-sulfamoyl-phenyl)-thiocarbamic acid O-(2-thiophen-3-yl-ethyl) ester 4-Methylimidazole AL5927 1,2,4-Triazole N-[2-(1h-Indol-5-Yl)-Butyl]-4-Sulfamoyl-Benzamide Al-6629, [2h-Thieno[3,2-E]-1,2-Thiazine-6-Sulfonamide,2-(3-Methoxyphenyl)-3-(4-Morpholinyl)-, 1,1-Dioxide] Methyl Mercury Ion 4-Sulfonamide-[1-(4-Aminobutane)]Benzamide N-(2,6-Diflouro-Benzyl)-4-Sulfamoyl-Benzamide AL4623 Urea (S)-N-(3-Indol-1-Yl-2-Methyl-Propyl)-4-Sulfamoyl-Benzamide Mercuribenzoic Acid 4-Sulfonamide-[4-(Thiomethylaminobutane)]Benzamide (4s-Trans)-4-(Methylamino)-5,6-Dihydro-6-Methyl-4h-Thieno(2,3-B)Thiopyran-2-Sulfonamide-7,7-Dioxide AL5300 4-(Aminosulfonyl)-N-[(2,4-Difluorophenyl)Methyl]-Benzamide 3-Mercuri-4-Aminobenzenesulfonamide AL6528 3-Nitro-4-(2-Oxo-Pyrrolidin-1-Yl)-Benzenesulfonamide 4-(Aminosulfonyl)-N-[(2,3,4-Trifluorophenyl)Methyl]-Benzamide 4-[(3-BROMO-4-O-SULFAMOYLBENZYL)(4-CYANOPHENYL)AMINO]-4H-[1,2,4]-TRIAZOLE 4-[(4-O-SULFAMOYLBENZYL)(4-CYANOPHENYL)AMINO]-4H-[1,2,4]-TRIAZOLE 1-N-(4-SULFAMOYLPHENYL-ETHYL)-2,4,6-TRIMETHYLPYRIDINIUM 5-{[(4-AMINO-3-CHLORO-5-FLUOROPHENYL)SULFONYL]AMINO}-1,3,4-THIADIAZOLE-2-SULFONAMIDE 2-(cycloheptylmethyl)-1,1-dioxido-1-benzothiophen-6-yl sulfamate N-[(2R)-5-(aminosulfonyl)-2,3-dihydro-1H-inden-2-yl]-2-propylpentanamide 5-[(phenylsulfonyl)amino]-1,3,4-thiadiazole-2-sulfonamide THIOPHENE-2,5-DISULFONIC ACID 2-AMIDE-5-(4-METHYL-BENZYLAMIDE) 4-chloro-N-[(2S)-2-methyl-2,3-dihydro-1H-indol-1-yl]-3-sulfamoylbenzamide N-[4-(AMINOSULFONYL)PHENYL]-2-MERCAPTOBENZAMIDE (17beta)-17-(cyanomethyl)-2-methoxyestra-1(10),2,4-trien-3-yl sulfamate 5-(2-chlorophenyl)-1,3,4-thiadiazole-2-sulfonamide PHENYLALANYLAMINODI(ETHYLOXY)ETHYL BENZENESULFONAMIDEAMINOCARBONYLBENZENESULFONAMIDE N-(2,3-DIFLUORO-BENZYL)-4-SULFAMOYL-BENZAMIDE 2-chloro-5-[(1S)-1-hydroxy-3-oxo-2H-isoindol-1-yl]benzenesulfonamide 2-(1,3-thiazol-4-yl)-1H-benzimidazole-5-sulfonamide N-{2-[4-(AMINOSULFONYL)PHENYL]ETHYL}ACETAMIDE 3-[4-(AMINOSULFONYL)PHENYL]PROPANOIC ACID ETHYL 3-[4-(AMINOSULFONYL)PHENYL]PROPANOATE indane-5-sulfonamide 4-({[(4-METHYLPIPERAZIN-1-YL)AMINO]CARBONOTHIOYL}AMINO)BENZENESULFONAMIDE N-({[4-(AMINOSULFONYL)PHENYL]AMINO}CARBONYL)-4-METHYLBENZENESULFONAMIDE SULTHIAME (9BETA,13ALPHA,14BETA,17ALPHA)-2-METHOXYESTRA-1,3,5(10)-TRIENE-3,17-DIYL DISULFAMATE (4aS,4bR,10bS,12aS)-12a-methyl-1,3-dioxo-2-(pyridin-3-ylmethyl)-1,2,3,4,4a,4b,5,6,10b,11,12,12a-dodecahydronaphtho[2,1-f]isoquinolin-8-yl sulfamate 6-CHLORO-3-(DICHLOROMETHYL)-3,4-DIHYDRO-2H-1,2,4-BENZOTHIADIAZINE-7-SULFONAMIDE 1,1-DIOXIDE 2-(hydrazinocarbonyl)-3-phenyl-1H-indole-5-sulfonamide 6-HYDROXY-1,3-BENZOTHIAZOLE-2-SULFONAMIDE 4-(2-AMINOETHYL)BENZENESULFONAMIDE Ellagic Acid
Diseases
GWAS			Blood trace element (Zn levels) ( 23720494)
Protein-Protein Interactions		12 interactors: CA2 CHP1 CHP2 DAXX MAP4K4 MAPK1 MAPK14 MDFI TESC TNIK WNK1 YWHAB	11 interactors: ANKZF1 DYNLL1 HSPD1 NONO PTCHD2 SLC4A1 SLC4A2 SLC4A3 SLC4A4 SLC4A8 SLC9A1
Entrez ID		6548	760
HPRD ID		00123	02023
Ensembl ID		ENSG00000090020	ENSG00000104267
Uniprot IDs		B2RAH2 P19634	P00918
PDB IDs		1Y4E 2BEC 2E30 2HTG 2KBV 2L0E 2YGG	12CA 1A42 1AM6 1AVN 1BCD 1BIC 1BN1 1BN3 1BN4 1BNM 1BNN 1BNQ 1BNT 1BNU 1BNV 1BNW 1BV3 1CA2 1CA3 1CAH 1CAI 1CAJ 1CAK 1CAL 1CAM 1CAN 1CAO 1CAY 1CAZ 1CCS 1CCT 1CCU 1CIL 1CIM 1CIN 1CNB 1CNC 1CNG 1CNH 1CNI 1CNJ 1CNK 1CNW 1CNX 1CNY 1CRA 1CVA 1CVB 1CVC 1CVD 1CVE 1CVF 1CVH 1DCA 1DCB 1EOU 1F2W 1FQL 1FQM 1FQN 1FQR 1FR4 1FR7 1FSN 1FSQ 1FSR 1G0E 1G0F 1G1D 1G3Z 1G45 1G46 1G48 1G4J 1G4O 1G52 1G53 1G54 1H4N 1H9N 1H9Q 1HCA 1HEA 1HEB 1HEC 1HED 1HVA 1I8Z 1I90 1I91 1I9L 1I9M 1I9N 1I9O 1I9P 1I9Q 1IF4 1IF5 1IF6 1IF7 1IF8 1IF9 1KWQ 1KWR 1LG5 1LG6 1LGD 1LUG 1LZV 1MOO 1MUA 1OKL 1OKM 1OKN 1OQ5 1RAY 1RAZ 1RZA 1RZB 1RZC 1RZD 1RZE 1T9N 1TB0 1TBT 1TE3 1TEQ 1TEU 1TG3 1TG9 1TH9 1THK 1TTM 1UGA 1UGB 1UGC 1UGD 1UGE 1UGF 1UGG 1XEG 1XEV 1XPZ 1XQ0 1YDA 1YDB 1YDC 1YDD 1YO0 1YO1 1YO2 1Z9Y 1ZE8 1ZFK 1ZFQ 1ZGE 1ZGF 1ZH9 1ZSA 1ZSB 1ZSC 2ABE 2AW1 2AX2 2CA2 2CBA 2CBB 2CBC 2CBD 2CBE 2EU2 2EU3 2EZ7 2F14 2FMG 2FMZ 2FNK 2FNM 2FNN 2FOQ 2FOS 2FOU 2FOV 2GD8 2GEH 2H15 2H4N 2HD6 2HKK 2HL4 2HNC 2HOC 2ILI 2NNG 2NNO 2NNS 2NNV 2NWO 2NWP 2NWY 2NWZ 2NXR 2NXS 2NXT 2O4Z 2OSF 2OSM 2POU 2POV 2POW 2Q1B 2Q1Q 2Q38 2QO8 2QOA 2QP6 2VVA 2VVB 2WD2 2WD3 2WEG 2WEH 2WEJ 2WEO 2X7S 2X7T 2X7U 3B4F 3BET 3BL0 3BL1 3C7P 3CA2 3CAJ 3CYU 3D8W 3D92 3D93 3D9Z 3DAZ 3DBU 3DC3 3DC9 3DCC 3DCS 3DCW 3DD0 3DD8 3DV7 3DVB 3DVC 3DVD 3EFI 3EFT 3F4X 3F8E 3FFP 3GZ0 3HFP 3HKN 3HKQ 3HKT 3HKU 3HLJ 3HS4 3IBI 3IBL 3IBN 3IBU 3IEO 3IGP 3K2F 3K34 3K7K 3KIG 3KKX 3KNE 3KOI 3KOK 3KON 3KS3 3KWA 3L14 3M04 3M14 3M1J 3M1K 3M1Q 3M1W 3M2N 3M2X 3M2Y 3M2Z 3M3X 3M40 3M5E 3M5S 3M5T 3M67 3M96 3M98 3MHC 3MHI 3MHL 3MHM 3MHO 3ML2 3MMF 3MNA 3MNH 3MNI 3MNJ 3MNK 3MNU 3MWO 3MYQ 3MZC 3N0N 3N2P 3N3J 3N4B 3NB5 3NI5 3NJ9 3OIK 3OIL 3OIM 3OKU 3OKV 3OY0 3OYQ 3OYS 3P3H 3P3J 3P44 3P4V 3P55 3P58 3P5A 3P5L 3PJJ 3PO6 3PYK 3QYK 3R16 3R17 3RG3 3RG4 3RGE 3RJ7 3RLD 3RYJ 3RYV 3RYX 3RYY 3RYZ 3RZ0 3RZ1 3RZ5 3RZ7 3RZ8 3S71 3S72 3S73 3S74 3S75 3S76 3S77 3S78 3S8X 3S9T 3SAP 3SAX 3SBH 3SBI 3T5U 3T5Z 3T82 3T83 3T84 3T85 3TMJ 3TVN 3TVO 3U3A 3U45 3U47 3U7C 3V2J 3V2M 3V3F 3V3G 3V3H 3V3I 3V3J 3V5G 3V7X 3VBD 4BCW 4CA2 4CAC 4DZ7 4DZ9 4E3D 4E3F 4E3G 4E3H 4E49 4E4A 4E5Q 4FIK 4FL7 4FPT 4FRC 4FU5 4FVN 4FVO 4G0C 4GGE 4GL1 4HBA 4HT0 4IDR 4ILX 4JS6 4JSA 4JSS 4JSW 4JSZ 4KAP 5CA2 5CAC 6CA2 7CA2 8CA2 9CA2
Enriched GO Terms of Interacting Partners?		Regulation Of Phosphorus Metabolic Process Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Regulation Of Phosphorylation Signal Transduction By Phosphorylation Regulation Of Catalytic Activity Regulation Of Protein Phosphorylation MAPK Cascade Activation Of Protein Kinase Activity Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Regulation Of MAPK Cascade Regulation Of Intracellular Signal Transduction Regulation Of Stress-activated MAPK Cascade Intracellular Signal Transduction Regulation Of Intracellular Transport Regulation Of Cellular Protein Metabolic Process Positive Regulation Of MAPK Cascade Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Regulation Of Signaling Positive Regulation Of Protein Modification Process Regulation Of Protein Metabolic Process Positive Regulation Of Transferase Activity Regulation Of Cellular Localization Cellular Response To Stimulus Regulation Of Protein Transport Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Dephosphorylation Regulation Of Establishment Of Protein Localization Phosphorylation Activation Of MAPK Activity Positive Regulation Of Protein Phosphorylation Positive Regulation Of Protein Metabolic Process Regulation Of Signal Transduction Positive Regulation Of Transport Positive Regulation Of Signal Transduction Negative Regulation Of Transport Regulation Of JNK Cascade Regulation Of Protein Localization Regulation Of Protein Import Into Nucleus Positive Regulation Of Sodium:proton Antiporter Activity Negative Regulation Of Protein Transport Positive Regulation Of Phosphorylation Regulation Of Protein Localization To Nucleus Positive Regulation Of Catalytic Activity Positive Regulation Of MAP Kinase Activity Regulation Of Nucleocytoplasmic Transport	Regulation Of Intracellular PH Regulation Of Cellular PH Regulation Of PH Bicarbonate Transport Cellular Cation Homeostasis Cellular Ion Homeostasis Chemical Homeostasis Cellular Chemical Homeostasis Ion Homeostasis Inorganic Anion Transport Cellular Homeostasis Homeostatic Process Anion Transmembrane Transport Organic Anion Transport Anion Transport Ion Transmembrane Transport Chloride Transmembrane Transport Chloride Transport Transmembrane Transport Ion Transport Sodium Ion Transmembrane Transport Sodium Ion Transport B Cell Cytokine Production Isotype Switching To IgG Isotypes Sodium Ion Import Across Plasma Membrane Sodium Ion Import Cardiac Muscle Cell Contraction Positive Regulation Of T Cell Mediated Immune Response To Tumor Cell Regulation Of The Force Of Heart Contraction By Cardiac Conduction Transport Positive Regulation Of Calcium:sodium Antiporter Activity Positive Regulation Of The Force Of Heart Contraction Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Regulation Of Apoptotic Process Monovalent Inorganic Cation Transport Positive Regulation Of Calcineurin-NFAT Signaling Cascade Regulation Of Cell Death Sodium Ion Export Positive Regulation Of NFAT Protein Import Into Nucleus Cellular Response To Acidic PH Positive Regulation Of Action Potential Negative Regulation Of Oxidative Stress-induced Neuron Death Response To Muscle Stretch Regulation Of Cardiac Muscle Cell Membrane Potential Positive Regulation Of Immune Response To Tumor Cell DNA Recombination Metal Ion Transport Positive Regulation Of Intracellular Transport Cellular Response To Electrical Stimulus Maintenance Of Cell Polarity
Tagcloud ?		atpases bicarbonate cotransporter dense diffusive dissected dysregulation electroneutral equivalents exchanger flux freshly hco hypothesize microenvironment nbcn1 nhe1 origins perfused proton publicly reflecting reflects slc26 slc4 slc4a7 summarize transporters unifying	adenine arsine atractyloside butacaine catalase classic consequent csa cyclosporin cytochrome derive dismutase disulfide dithiol ethylmaleimide mpp mtp opening opens permeability phenylpyridinium pore reagent rotenone ruthenium scavenging situations swelling translocator uniporter
Tagcloud (Difference) ?		atpases bicarbonate cotransporter dense diffusive dissected dysregulation electroneutral equivalents exchanger flux freshly hco hypothesize microenvironment nbcn1 nhe1 origins perfused proton publicly reflecting reflects slc26 slc4 slc4a7 summarize transporters unifying	adenine arsine atractyloside butacaine catalase classic consequent csa cyclosporin cytochrome derive dismutase disulfide dithiol ethylmaleimide mpp mtp opening opens permeability phenylpyridinium pore reagent rotenone ruthenium scavenging situations swelling translocator uniporter
Tagcloud (Intersection) ?