MED17 and USP49

Number of citations of the paper that reports this interaction (PubMedID 14576168)
0

Data Source:
HPRD (in vivo)

		MED17	USP49
Description		mediator complex subunit 17	ubiquitin specific peptidase 49
Image			No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Transcription Regulator Complex Membrane Mediator Complex Core Mediator Complex	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Transcription Coregulator Activity Transcription Coactivator Activity Protein Binding Nuclear Vitamin D Receptor Binding Nuclear Thyroid Hormone Receptor Binding Ubiquitin Protein Ligase Activity	Cysteine-type Endopeptidase Activity Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Zinc Ion Binding Hydrolase Activity Histone Binding Metal Ion Binding Histone H2B Deubiquitinase Activity
	Biological Process	Regulation Of Transcription By RNA Polymerase II Transcription Initiation At RNA Polymerase II Promoter Protein Ubiquitination Positive Regulation Of Transcription Elongation By RNA Polymerase II Somatic Stem Cell Population Maintenance Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Preinitiation Complex Assembly Positive Regulation Of Transcription Initiation By RNA Polymerase II	MRNA Splicing, Via Spliceosome Chromatin Organization Chromatin Remodeling MRNA Processing Proteolysis RNA Splicing Protein Deubiquitination Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Pathways		PPARA activates gene expression Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation RSV-host interactions MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	Ub-specific processing proteases
Drugs
Diseases
GWAS			Cutaneous psoriasis ( 26626624) Hip circumference adjusted for BMI ( 34021172) Mean corpuscular hemoglobin ( 32888494 20139978) Mean corpuscular volume ( 23263863 27863252 32888494 20139978) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Neutrophil percentage of white cells ( 32888494) Platelet distribution width ( 32888494) Red blood cell count ( 27863252 20139978 32888494) Reticulocyte count ( 32888494) Skin aging (microtopography measurement) ( 28502801) Sleep duration (short sleep) ( 30846698)
Interacting Genes		17 interacting genes: BCL6 CEBPA CTDP1 ESR1 ESR2 HEMGN HNF4A MED19 MED22 MED30 MED8 PPARGC1A SMARCA4 SREBF1 SUZ12 TP53 USP49	11 interacting genes: H2BC21 MED17 MED18 MED8 NAMPT PTCD2 RBCK1 STING1 TP53 TRIM35 ZNF774
Entrez ID		9440	25862
HPRD ID		04816	10075
Ensembl ID		ENSG00000042429	ENSG00000164663
Uniprot IDs		Q9NVC6	Q70CQ1
PDB IDs		7EMF 7ENA 7ENC 7ENJ 7LBM 7NVR 8GXQ 8GXS 8T9D 8TQW 8TRH
Enriched GO Terms of Interacting Partners?		Nucleoplasm Regulation Of Transcription By RNA Polymerase II Transcription Preinitiation Complex Assembly Positive Regulation Of DNA-templated Transcription Initiation Positive Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Initiation Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process RNA Polymerase II Preinitiation Complex Assembly Regulation Of RNA Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription Initiation By RNA Polymerase II Sequence-specific DNA Binding Chromatin Binding Positive Regulation Of RNA Metabolic Process Regulation Of Transcription Initiation By RNA Polymerase II Negative Regulation Of Cell Growth Regulation Of Nucleobase-containing Compound Metabolic Process Core Mediator Complex Protein-DNA Complex Assembly Positive Regulation Of Nucleobase-containing Compound Metabolic Process Mediator Complex Negative Regulation Of Growth Nucleus RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Transcription Coregulator Activity Nuclear Receptor Activity Regulation Of Gene Expression Positive Regulation Of Transcription Elongation By RNA Polymerase II Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of DNA-templated Transcription, Elongation Regulation Of Primary Metabolic Process Positive Regulation Of Biosynthetic Process Nucleobase-containing Compound Biosynthetic Process Regulation Of MiRNA Transcription Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Chromatin DNA Binding Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Growth Regulation Of MiRNA Metabolic Process DNA-binding Transcription Factor Activity RNA Metabolic Process Regulation Of Transcription Elongation By RNA Polymerase II Negative Regulation Of RNA Metabolic Process DNA-templated Transcription Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Elongation	Positive Regulation Of DNA-templated Transcription Initiation Positive Regulation Of Transcription Initiation By RNA Polymerase II Regulation Of Transcription Initiation By RNA Polymerase II Regulation Of DNA-templated Transcription Initiation Core Mediator Complex Mediator Complex RNA Polymerase II Preinitiation Complex Assembly Protein-DNA Complex Assembly Positive Regulation Of Transcription Elongation By RNA Polymerase II Transcription Preinitiation Complex Assembly Positive Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of DNA-templated Transcription Regulation Of Transcription Elongation By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Elongation Regulation Of Nucleobase-containing Compound Metabolic Process Protein-containing Complex Assembly Positive Regulation Of Transcription By RNA Polymerase II Ubiquitin Protein Ligase Activity Positive Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Coregulator Activity Protein-containing Complex Organization Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Programmed Necrotic Cell Death Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Positive Regulation Of Biosynthetic Process Protein Ubiquitination Negative Regulation Of Helicase Activity Negative Regulation Of G1 To G0 Transition Nicotinamide Phosphoribosyltransferase Activity Cyclic-di-GMP Binding STING Complex Transcription Coactivator Activity Protein Modification By Small Protein Conjugation Regulation Of Macromolecule Metabolic Process Defense Response Positive Regulation Of Macromolecule Metabolic Process Oligodendrocyte Apoptotic Process Negative Regulation Of Pentose-phosphate Shunt Negative Regulation Of Glucose Catabolic Process To Lactate Via Pyruvate 2',3'-cyclic GMP-AMP Binding Post-translational Protein Modification Negative Regulation Of Fermentation
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