MED17 and SREBF1

Number of citations of the paper that reports this interaction (PMID 16799563)
79

Data Source:
BioGRID (affinity chromatography technology, pull down)

		MED17	SREBF1
Gene Name		mediator complex subunit 17	sterol regulatory element binding transcription factor 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Factor Complex Membrane Mediator Complex	Golgi Membrane Nucleus Nuclear Envelope Nucleoplasm Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol ER To Golgi Transport Vesicle Membrane Integral Component Of Membrane Protein Complex
	Molecular Function	RNA Polymerase II Transcription Cofactor Activity Transcription Cofactor Activity Transcription Coactivator Activity Receptor Activity Protein Binding Ligand-dependent Nuclear Receptor Transcription Coactivator Activity Vitamin D Receptor Binding Thyroid Hormone Receptor Binding	DNA Binding Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Protein Kinase Binding Protein Complex Binding Sterol Response Element Binding Sequence-specific DNA Binding Protein Dimerization Activity
	Biological Process	Regulation Of Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Gene Expression Stem Cell Maintenance Intracellular Steroid Hormone Receptor Signaling Pathway Androgen Receptor Signaling Pathway Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter	Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Heart Rate By Chemical Signal Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Lipid Metabolic Process Aging Circadian Rhythm Cholesterol Metabolic Process Insulin Receptor Signaling Pathway Lipid Biosynthetic Process Cellular Response To Starvation Response To Glucose Positive Regulation Of Triglyceride Biosynthetic Process Regulation Of Fatty Acid Metabolic Process Lung Development Positive Regulation Of Histone Deacetylation Response To Food Response To Retinoic Acid Response To Progesterone Response To Glucagon Response To Drug Cellular Lipid Metabolic Process Small Molecule Metabolic Process Positive Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Insulin Secretion Response To CAMP Cellular Response To Fatty Acid
Pathways		PPARA activates gene expression Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)	RORA activates circadian gene expression
Drugs
Diseases
GWAS			Parkinson's disease ( 21738487)
Protein-Protein Interactions		16 interactors: BCL6 CTDP1 ESR1 ESR2 HNF4A MED19 MED22 MED29 MED30 MED8 PPARGC1A SMARCA4 SREBF1 SUZ12 TP53 USP49	35 interactors: AR ATXN1 ATXN1L CDK8 CREBBP ESR1 ESR2 GSK3B HNF4A ID3 KLF13 LMNA MAPK1 MAPK3 MED1 MED12 MED13 MED14 MED17 MED23 MED24 MED25 MED26 MED6 MED7 NR0B1 SIRT1 SMARCD3 SP1 SREBF2 SUMO1 TWIST2 UBE2I YY1 ZBTB7C
Entrez ID		9440	6720
HPRD ID		04816	01701
Ensembl ID			ENSG00000072310
Uniprot IDs		Q9NVC6	B4DEU6 P36956
PDB IDs			1AM9
Enriched GO Terms of Interacting Partners?		Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Metabolic Process RNA Biosynthetic Process Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter Nucleobase-containing Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Macromolecule Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Biosynthetic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Transcription Initiation From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription DNA-templated Transcription, Initiation Regulation Of Metabolic Process Negative Regulation Of Cell Growth Positive Regulation Of Histone Modification Positive Regulation Of Histone Deacetylation Intracellular Steroid Hormone Receptor Signaling Pathway Intracellular Receptor Signaling Pathway Positive Regulation Of Protein Deacetylation Negative Regulation Of Growth Regulation Of Histone Deacetylation Regulation Of Histone Modification Rhythmic Process Cellular Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Regulation Of Cell Growth Positive Regulation Of Cellular Biosynthetic Process Regulation Of Protein Deacetylation Cellular Response To Lipid Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Chromosome Organization Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Regulation Of Cellular Process Regulation Of Cell Proliferation Cellular Response To Hormone Stimulus Negative Regulation Of Androgen Receptor Signaling Pathway	Regulation Of Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Transcription From RNA Polymerase II Promoter Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process RNA Metabolic Process Positive Regulation Of Gene Expression Gene Expression Positive Regulation Of Transcription, DNA-templated Nucleobase-containing Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Intracellular Steroid Hormone Receptor Signaling Pathway Positive Regulation Of Metabolic Process Intracellular Receptor Signaling Pathway Androgen Receptor Signaling Pathway Cellular Metabolic Process Negative Regulation Of Cell Differentiation Negative Regulation Of Biosynthetic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Transcription From RNA Polymerase II Promoter Anatomical Structure Development Regulation Of Cellular Process Negative Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Developmental Process Regulation Of Cellular Response To Heat Regulation Of Cell Differentiation Organ Development Cell Differentiation Metabolic Process
Tagcloud ?		cdk colocalized concentrated connecting eukaryotes excision head helicase hinge holo interacted jaw module modules movable ner nutlin performs pol pulldown switching tbp tfiib tfiie tfiih uv xpb xpg	aberrations acly biphasic cascade chemoprevention citrate desaturase disturbed fads2 fatty harboring hbv hcc hepatocytes lipid livers lyase metabolism mtor pre remarkably s2 starting sterol subsided synchronized transgenic tumorigenesis upregulate
Tagcloud (Difference) ?		cdk colocalized concentrated connecting eukaryotes excision head helicase hinge holo interacted jaw module modules movable ner nutlin performs pol pulldown switching tbp tfiib tfiie tfiih uv xpb xpg	aberrations acly biphasic cascade chemoprevention citrate desaturase disturbed fads2 fatty harboring hbv hcc hepatocytes lipid livers lyase metabolism mtor pre remarkably s2 starting sterol subsided synchronized transgenic tumorigenesis upregulate
Tagcloud (Intersection) ?