MED17 and MED19

Number of citations of the paper that reports this interaction (PMID 21729782)
60

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro)

		MED17	MED19
Gene Name		mediator complex subunit 17	mediator complex subunit 19
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Factor Complex Membrane Mediator Complex	Nucleus Mediator Complex
	Molecular Function	RNA Polymerase II Transcription Cofactor Activity Transcription Cofactor Activity Transcription Coactivator Activity Receptor Activity Protein Binding Ligand-dependent Nuclear Receptor Transcription Coactivator Activity Vitamin D Receptor Binding Thyroid Hormone Receptor Binding	RNA Polymerase II Transcription Cofactor Activity Protein Binding
	Biological Process	Regulation Of Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Gene Expression Stem Cell Maintenance Intracellular Steroid Hormone Receptor Signaling Pathway Androgen Receptor Signaling Pathway Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter	Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter
Pathways		PPARA activates gene expression Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)	PPARA activates gene expression Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Transcriptional regulation of white adipocyte differentiation Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Drugs
Diseases
GWAS
Protein-Protein Interactions		16 interactors: BCL6 CTDP1 ESR1 ESR2 HNF4A MED19 MED22 MED29 MED30 MED8 PPARGC1A SMARCA4 SREBF1 SUZ12 TP53 USP49	11 interactors: APP DCK DHRS7B MED17 MED27 MED31 MED8 MED9 MSX1 NFKBIA RADIL
Entrez ID		9440	219541
HPRD ID		04816	17477
Ensembl ID			ENSG00000156603
Uniprot IDs		Q9NVC6	A0JLT2
PDB IDs
Enriched GO Terms of Interacting Partners?		Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Metabolic Process RNA Biosynthetic Process Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter Nucleobase-containing Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Macromolecule Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Biosynthetic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Transcription Initiation From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription DNA-templated Transcription, Initiation Regulation Of Metabolic Process Negative Regulation Of Cell Growth Positive Regulation Of Histone Modification Positive Regulation Of Histone Deacetylation Intracellular Steroid Hormone Receptor Signaling Pathway Intracellular Receptor Signaling Pathway Positive Regulation Of Protein Deacetylation Negative Regulation Of Growth Regulation Of Histone Deacetylation Regulation Of Histone Modification Rhythmic Process Cellular Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Regulation Of Cell Growth Positive Regulation Of Cellular Biosynthetic Process Regulation Of Protein Deacetylation Cellular Response To Lipid Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Chromosome Organization Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Regulation Of Cellular Process Regulation Of Cell Proliferation Cellular Response To Hormone Stimulus Negative Regulation Of Androgen Receptor Signaling Pathway	Regulation Of Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Negative Regulation Of Cell Differentiation Intracellular Receptor Signaling Pathway Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Stem Cell Development Regulation Of Binding Negative Regulation Of DNA Binding Transcription, DNA-templated Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Gene Expression Regulation Of Gene Expression RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Stem Cell Differentiation Cellular Nitrogen Compound Metabolic Process Regulation Of Cell Differentiation Nitrogen Compound Metabolic Process Regulation Of DNA Binding Cell Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway Synaptic Growth At Neuromuscular Junction Negative Regulation Of Binding Collateral Sprouting In Absence Of Injury Positive Regulation Of Mesenchymal Cell Apoptotic Process Embryonic Nail Plate Morphogenesis Positive Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Activation Of Meiosis Biosynthetic Process Stem Cell Maintenance Collateral Sprouting BMP Signaling Pathway Involved In Heart Development Axon Midline Choice Point Recognition Positive Regulation Of Transcription, DNA-templated Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Cytoplasmic Sequestering Of NF-kappaB Protein Localization To Nucleus Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process
Tagcloud ?		cdk colocalized concentrated connecting eukaryotes excision head helicase hinge holo interacted jaw module modules movable ner nutlin performs pol pulldown switching tbp tfiib tfiie tfiih uv xpb xpg	adp b1 cyclin downregulated enneking iib iiib ki67 knockdown mediator multimodal nearly nude oncogene oncogenes os osteosarcoma parp pcna proliferating remarkably ribose saos simultaneously spreading tumour tumourigenesis u2os xenograft
Tagcloud (Difference) ?		cdk colocalized concentrated connecting eukaryotes excision head helicase hinge holo interacted jaw module modules movable ner nutlin performs pol pulldown switching tbp tfiib tfiie tfiih uv xpb xpg	adp b1 cyclin downregulated enneking iib iiib ki67 knockdown mediator multimodal nearly nude oncogene oncogenes os osteosarcoma parp pcna proliferating remarkably ribose saos simultaneously spreading tumour tumourigenesis u2os xenograft
Tagcloud (Intersection) ?