MED17 and SUZ12

Number of citations of the paper that reports this interaction (PubMedID 22668559)
0

Data Source:
BioGRID (pull down)

		MED17	SUZ12
Description		mediator complex subunit 17	SUZ12 polycomb repressive complex 2 subunit
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Transcription Regulator Complex Membrane Mediator Complex Core Mediator Complex	Sex Chromatin Nucleus Nucleoplasm Chromatin Silencing Complex Nucleolus RSC-type Complex Nuclear Body Protein-DNA Complex ESC/E(Z) Complex Ribonucleoprotein Complex
	Molecular Function	Transcription Coregulator Activity Transcription Coactivator Activity Protein Binding Nuclear Vitamin D Receptor Binding Nuclear Thyroid Hormone Receptor Binding Ubiquitin Protein Ligase Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Transcription Corepressor Binding Chromatin Binding RNA Binding Protein Binding Enzyme Activator Activity Zinc Ion Binding Chromatin DNA Binding Sequence-specific DNA Binding Metal Ion Binding Histone H3K9me2/3 Reader Activity LncRNA Binding Promoter-specific Chromatin Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Transcription Initiation At RNA Polymerase II Promoter Protein Ubiquitination Positive Regulation Of Transcription Elongation By RNA Polymerase II Somatic Stem Cell Population Maintenance Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Preinitiation Complex Assembly Positive Regulation Of Transcription Initiation By RNA Polymerase II	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Differentiation Oligodendrocyte Differentiation Random Inactivation Of X Chromosome Facultative Heterochromatin Formation
Pathways		PPARA activates gene expression Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation RSV-host interactions MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	PRC2 methylates histones and DNA Oxidative Stress Induced Senescence PKMTs methylate histone lysines SUMOylation of chromatin organization proteins Activation of anterior HOX genes in hindbrain development during early embryogenesis Regulation of PTEN gene transcription Regulation of PTEN gene transcription Transcriptional Regulation by E2F6 HCMV Early Events Defective pyroptosis Negative Regulation of CDH1 Gene Transcription Regulation of PD-L1(CD274) transcription
Drugs
Diseases
GWAS			High chromosomal aberration frequency (chromosome type) ( 31586183) Hip circumference adjusted for BMI ( 25673412)
Interacting Genes		17 interacting genes: BCL6 CEBPA CTDP1 ESR1 ESR2 HEMGN HNF4A MED19 MED22 MED30 MED8 PPARGC1A SMARCA4 SREBF1 SUZ12 TP53 USP49	18 interacting genes: AEBP2 BCL11A CDK19 CDK8 CREB1 EZH2 H1-1 H3-4 LATS2 MED17 MED6 PAXIP1 PJA1 PRDM14 RNF10 UBC UBE2I WDR77
Entrez ID		9440	23512
HPRD ID		04816	06949
Ensembl ID		ENSG00000042429	ENSG00000178691
Uniprot IDs		Q9NVC6	J3QQW9 Q15022
PDB IDs		7EMF 7ENA 7ENC 7ENJ 7LBM 7NVR 8GXQ 8GXS 8T9D 8TQW 8TRH	4W2R 5HYN 5IJ7 5IJ8 5LS6 5WAI 5WAK 5WG6 6B3W 6C23 6C24 6NQ3 6WKR 7AT8 7KSO 7KSR 7KTP 7TD5 8EQV 8FYH 8T9G 8TAS 8TB9 8VMI 8VML 8VNV 8VNZ 9C8U 9DCH
Enriched GO Terms of Interacting Partners?		Nucleoplasm Regulation Of Transcription By RNA Polymerase II Transcription Preinitiation Complex Assembly Positive Regulation Of DNA-templated Transcription Initiation Positive Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Initiation Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process RNA Polymerase II Preinitiation Complex Assembly Regulation Of RNA Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription Initiation By RNA Polymerase II Sequence-specific DNA Binding Chromatin Binding Positive Regulation Of RNA Metabolic Process Regulation Of Transcription Initiation By RNA Polymerase II Negative Regulation Of Cell Growth Regulation Of Nucleobase-containing Compound Metabolic Process Core Mediator Complex Protein-DNA Complex Assembly Positive Regulation Of Nucleobase-containing Compound Metabolic Process Mediator Complex Negative Regulation Of Growth Nucleus RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Transcription Coregulator Activity Nuclear Receptor Activity Regulation Of Gene Expression Positive Regulation Of Transcription Elongation By RNA Polymerase II Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of DNA-templated Transcription, Elongation Regulation Of Primary Metabolic Process Positive Regulation Of Biosynthetic Process Nucleobase-containing Compound Biosynthetic Process Regulation Of MiRNA Transcription Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Chromatin DNA Binding Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Growth Regulation Of MiRNA Metabolic Process DNA-binding Transcription Factor Activity RNA Metabolic Process Regulation Of Transcription Elongation By RNA Polymerase II Negative Regulation Of RNA Metabolic Process DNA-templated Transcription Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Elongation	Nucleoplasm Protein Modification Process ESC/E(Z) Complex Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA-templated Transcription Initiation Positive Regulation Of Transcription Initiation By RNA Polymerase II Regulation Of Transcription Initiation By RNA Polymerase II Protein Modification By Small Protein Conjugation Inner Cell Mass Cell Fate Commitment Regulation Of DNA-templated Transcription Initiation Protein-DNA Complex Assembly Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Nucleus Regulation Of Nucleobase-containing Compound Metabolic Process CKM Complex Mediator Complex Regulation Of Developmental Process Post-translational Protein Modification Maintenance Of Cell Number Regulation Of RNA Metabolic Process Transcription Coregulator Activity DNA Replication-dependent Chromatin Assembly Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Protein Metabolic Process Transferase Complex Regulation Of Multicellular Organismal Process Regulation Of Primary Metabolic Process Negative Regulation Of RNA Metabolic Process G1 To G0 Transition Chromatin Organization Positive Regulation Of RNA Metabolic Process Protein Ubiquitination Chromatin DNA Binding Response To L-glutamate Regulation Of Cell Differentiation Regulation Of Transcription Elongation By RNA Polymerase II Chromatin Remodeling Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Gliogenesis Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Chromosome Regulation Of DNA-templated Transcription Elongation Rhythmic Process Nucleosome Assembly
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