HAND1 and TCF12

Number of citations of the paper that reports this interaction (PMID 11802795)
11

Data Source:
HPRD (in vitro)

		HAND1	TCF12
Gene Name		heart and neural crest derivatives expressed 1	transcription factor 12
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm RNA Polymerase II Transcription Factor Complex	Nuclear Chromatin Nucleus Cytoplasm RNA Polymerase II Transcription Factor Complex
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Transcription Factor Binding Enzyme Binding Identical Protein Binding Protein Homodimerization Activity BHLH Transcription Factor Binding Transcription Regulatory Region DNA Binding Protein Heterodimerization Activity	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transcription Factor Binding Enhancer Binding BHLH Transcription Factor Binding Transcription Regulatory Region DNA Binding SMAD Binding Protein Heterodimerization Activity E-box Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Angiogenesis Mesoderm Formation Blastocyst Development Trophectodermal Cell Differentiation Heart Looping Embryonic Heart Tube Formation Cardiac Left Ventricle Formation Cardiac Right Ventricle Formation Transcription From RNA Polymerase II Promoter Heart Development Embryonic Heart Tube Development Odontogenesis Of Dentin-containing Tooth Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Ventricular Cardiac Muscle Tissue Morphogenesis Cardiac Septum Morphogenesis Mesenchyme Development Cartilage Morphogenesis Trophoblast Giant Cell Differentiation Negative Regulation Of RNA Polymerase II Regulatory Region Sequence-specific DNA Binding	Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Immune Response Muscle Organ Development Positive Regulation Of Neuron Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter
Pathways			CDO in myogenesis Myogenesis
Drugs
Diseases
GWAS		Ventricular conduction ( 21076409)
Protein-Protein Interactions		13 interactors: ACHE FHL2 HAND2 HEY2 HEYL MEF2A MYOD1 PPP2R5D PRKACA PRKCA SRA1 TCF12 TCF3	48 interactors: ARMC8 ASCL4 BMF C16orf45 C1orf109 C6orf165 CDKN2C CRCP CREBBP DGCR6 EDRF1 EP300 HAND1 HEXIM2 HOPX ID1 ID2 ID3 LYSMD1 MAPKBP1 MLLT6 MORN4 MSC NAGK NEUROG3 OLIG3 OSGIN1 PRSS23 PSMA1 PTF1A QARS RNASEL RUNX1T1 SOX10 SOX8 SPG21 SRI STAT5A STK16 TAF4 TAL2 TBP TCF23 TCF3 TRIM72 TSNAX TWIST2 VPS28
Entrez ID		9421	6938
HPRD ID		03871	02725
Ensembl ID		ENSG00000113196	ENSG00000140262
Uniprot IDs		O96004	B4E1W1 F5GY10 Q99081
PDB IDs			2KNH 4JOL
Enriched GO Terms of Interacting Partners?		Muscle Structure Development Positive Regulation Of Cellular Biosynthetic Process Cell Differentiation Tissue Development Transcription From RNA Polymerase II Promoter Muscle Organ Development Developmental Process Organ Development Cardiac Chamber Development System Development Regulation Of Cell Differentiation Outflow Tract Morphogenesis Gene Expression Multicellular Organismal Development Cell Development Positive Regulation Of Cellular Metabolic Process Cardiac Ventricle Morphogenesis Anatomical Structure Development Ventricular Cardiac Muscle Cell Development Heart Morphogenesis Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Cell Differentiation Cardiovascular System Development Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Dense Core Granule Biogenesis Cardiac Ventricle Development Positive Regulation Of Gene Expression Ventricular Cardiac Muscle Cell Differentiation Regulation Of Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Nervous System Development Transcription, DNA-templated Anatomical Structure Formation Involved In Morphogenesis Striated Muscle Tissue Development Stem Cell Differentiation Muscle Cell Differentiation RNA Biosynthetic Process Muscle Tissue Development Tissue Morphogenesis Cardiocyte Differentiation Positive Regulation Of Metabolic Process Mesenchymal Cell Differentiation Heart Valve Morphogenesis Histone H3-T6 Phosphorylation Heart Valve Development Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Muscle Cell Differentiation Striated Muscle Cell Development Cellular Macromolecule Biosynthetic Process Biosynthetic Process	Gene Expression Transcription, DNA-templated RNA Metabolic Process RNA Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Gene Expression Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process Cellular Macromolecule Biosynthetic Process Organ Development Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Multicellular Organismal Development Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Developmental Process Regulation Of Transcription, DNA-templated Nitrogen Compound Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process System Development Transcription From RNA Polymerase II Promoter Biosynthetic Process Anatomical Structure Development Regulation Of DNA Binding Regulation Of Binding Negative Regulation Of DNA Binding Positive Regulation Of Transcription, DNA-templated Muscle Organ Development Central Nervous System Development Regulation Of Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Muscle Structure Development Cell Differentiation Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Cell Differentiation Negative Regulation Of Binding Rhythmic Process Regulation Of Cellular Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Tagcloud ?		accessible cardiogenesis cardiomyogenesis competence confers corepressors decommissioned dispensable divergence ectopic emerges enhancers epigenetically exclusive exploits fates gata4 hemogenic landscape mesoderm multipotent mutually occupying opposing orchestrated pioneer prevents primed recruiting	cadherin cascade cd91 connexin consistently crc drastically ectopic efficiently enhancement facilitated fibronectin gap hsp90alpha ikappabalpha ikkalpha ikks invasion junction knocked mesenchymal migration motifs outgrowths repressed rhsp90alpha secreted spherical spreading
Tagcloud (Difference) ?		accessible cardiogenesis cardiomyogenesis competence confers corepressors decommissioned dispensable divergence emerges enhancers epigenetically exclusive exploits fates gata4 hemogenic landscape mesoderm multipotent mutually occupying opposing orchestrated pioneer prevents primed recruiting	cadherin cascade cd91 connexin consistently crc drastically efficiently enhancement facilitated fibronectin gap hsp90alpha ikappabalpha ikkalpha ikks invasion junction knocked mesenchymal migration motifs outgrowths repressed rhsp90alpha secreted spherical spreading
Tagcloud (Intersection) ?		ectopic