TCF12 and RNASEL

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		TCF12	RNASEL
Description		transcription factor 12	ribonuclease L
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Nuclear Speck RNA Polymerase II Transcription Regulator Complex	Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol Nuclear Matrix
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding CAMP Response Element Binding BHLH Transcription Factor Binding SMAD Binding Protein Heterodimerization Activity Protein Dimerization Activity E-box Binding HMG Box Domain Binding DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding	Nucleotide Binding RNA Binding Nuclease Activity Endonuclease Activity RNA Endonuclease Activity RNA Nuclease Activity Protein Kinase Activity Protein Binding ATP Binding Zinc Ion Binding Hydrolase Activity RRNA Binding Identical Protein Binding Ribonucleoprotein Complex Binding Metal Ion Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Immune Response Nervous System Development Muscle Organ Development Gene Expression Positive Regulation Of Gene Expression Cell Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Response To Gonadotropin-releasing Hormone	RRNA Processing RNA Processing MRNA Processing Protein Phosphorylation Regulation Of Gene Expression Regulation Of MRNA Stability Negative Regulation Of Viral Genome Replication Fat Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of D-glucose Import Regulation Of RNA Metabolic Process Defense Response To Virus
Pathways		Myogenesis Myogenesis RUNX1 regulates transcription of genes involved in differentiation of HSCs NGF-stimulated transcription NGF-stimulated transcription Negative Regulation of CDH1 Gene Transcription TGFBR3 expression	OAS antiviral response Interferon alpha/beta signaling
Drugs
Diseases
GWAS		3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Alcohol consumption (drinks per week) ( 30643258) Apolipoprotein B levels ( 32203549) Body mass index ( 28892062) Glaucoma (primary open-angle) ( 29891935 33627673) LDL cholesterol levels ( 32203549) Low density lipoprotein cholesterol levels ( 32154731) Male-pattern baldness ( 28196072) Mean platelet volume ( 27863252 32888494) Triglyceride levels ( 32154731) Type 2 diabetes ( 30297969)	Morning vs. evening chronotype ( 26835600) Multiple sclerosis ( 23412934)
Interacting Genes		68 interacting genes: AIRIM ARL16 ARMC8 ASCL4 BMERB1 BMF CDKN2C CFAP206 CKS1B CLCNKA CRCP CREBBP DDX6 DGCR6 EDRF1 EP300 EXOC8 FRMD6 GRB7 HAND1 HOPX ID1 ID2 ID3 LAMTOR5 LNX1 LYSMD1 MAPKBP1 MLLT6 MORN4 MSC MYF6 MYO15B NAGK NEK6 NEUROD1 NEUROG1 NGLY1 NHLH2 OLIG3 OSGIN1 PIN1 PRKAB2 PRSS23 PSMA1 PTF1A QARS1 RBM8A RNASEL RUNX1T1 SOX10 SOX8 SPG21 SRI STAT5A STK16 TAF4 TAL2 TBC1D21 TBP TCF21 TCF3 TMEM132D TRIM72 TSNAX VPS28 WTAP ZNF688	4 interacting genes: ABCE1 AR RNF10 TCF12
Entrez ID		6938	6041
HPRD ID		02725	01590
Ensembl ID		ENSG00000140262	ENSG00000135828
Uniprot IDs		F5GY10 Q99081	Q05823
PDB IDs		2KNH 4JOL	1WDY 4G8K 4G8L 4OAU 4OAV
Enriched GO Terms of Interacting Partners?		Protein Dimerization Activity Chromatin DNA-binding Transcription Factor Binding E-box Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Cell Fate Commitment Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Positive Regulation Of RNA Metabolic Process Animal Organ Development Regulation Of Macromolecule Biosynthetic Process Neuron Differentiation BHLH Transcription Factor Binding Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Regulator Complex Positive Regulation Of Nucleobase-containing Compound Metabolic Process Histone H3K27 Acetyltransferase Activity Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Biosynthetic Process Nucleus Regulation Of Metabolic Process RNA Polymerase II Transcription Regulator Complex Striated Muscle Tissue Development Transcription Regulator Inhibitor Activity Nucleoplasm Regulation Of Macromolecule Metabolic Process Tau Protein Binding Oligodendrocyte Differentiation Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Histone H3K18 Acetyltransferase Activity N-terminal Peptidyl-lysine Acetylation Peptide Lactyltransferase (CoA-dependent) Activity Thigmotaxis Branchiomeric Skeletal Muscle Development Muscle Tissue Development Cytoplasm Negative Regulation Of Macromolecule Biosynthetic Process Cell Differentiation DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Developmental Process	Ribosome-associated Ubiquitin-dependent Protein Catabolic Process Transcription Cis-regulatory Region Binding Prostate Induction Male Somatic Sex Determination Cytosolic Ribosome Negative Regulation Of Endoribonuclease Activity Lateral Sprouting Involved In Mammary Gland Duct Morphogenesis Androgen Binding Male Genitalia Morphogenesis POU Domain Binding Tertiary Branching Involved In Mammary Gland Duct Morphogenesis Positive Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Positive Regulation Of Integrin Biosynthetic Process Negative Regulation Of Nuclease Activity Regulation Of Ribonuclease Activity Endoribonuclease Inhibitor Activity Cytoplasmic Translational Elongation Regulation Of Endoribonuclease Activity CTPase Activity CAT Tailing Postsynapse To Nucleus Signaling Pathway Extrinsic Component Of Postsynaptic Density Membrane Gene Expression RNA Polymerase II General Transcription Initiation Factor Binding Regulation Of RNA Metabolic Process Cellular Response To Testosterone Stimulus Regulation Of Prostatic Bud Formation Positive Regulation Of Transcription By RNA Polymerase II Response To Gonadotropin-releasing Hormone Negative Regulation Of Schwann Cell Proliferation Regulation Of Nucleobase-containing Compound Metabolic Process Genitalia Morphogenesis Lateral Sprouting From An Epithelium Leydig Cell Differentiation Estrogen Response Element Binding Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Macromolecule Biosynthetic Process Prostate Gland Growth Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Epithelial Cell Differentiation Involved In Prostate Gland Development Regulation Of Cell Differentiation Translational Termination Protein Ufmylation HMG Box Domain Binding CAMP Response Element Binding Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Ribonucleoside Triphosphate Phosphatase Activity Male Sex Determination Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Positive Regulation Of RNA Biosynthetic Process
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