TCF12 and PTF1A

Number of citations of the paper that reports this interaction (PMID 1720355)
15

Data Source:
HPRD (in vitro)

		TCF12	PTF1A
Gene Name		transcription factor 12	pancreas specific transcription factor, 1a
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Chromatin Nucleus Cytoplasm RNA Polymerase II Transcription Factor Complex	Nucleus Transcription Factor Complex Cytoplasm
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transcription Factor Binding Enhancer Binding BHLH Transcription Factor Binding Transcription Regulatory Region DNA Binding SMAD Binding Protein Heterodimerization Activity E-box Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription DNA Binding Chromatin Binding Sequence-specific DNA Binding Protein Dimerization Activity E-box Binding
	Biological Process	Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Immune Response Muscle Organ Development Positive Regulation Of Neuron Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Embryo Development Tissue Development Retina Layer Formation Cerebellum Development Pancreas Development Exocrine Pancreas Development Endocrine Pancreas Development Amacrine Cell Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Retinoic Acid Receptor Signaling Pathway Neuron Fate Commitment Regulation Of Neural Retina Development
Pathways		CDO in myogenesis Myogenesis	Regulation of beta-cell development Regulation of gene expression in early pancreatic precursor cells
Drugs
Diseases
GWAS
Protein-Protein Interactions		48 interactors: ARMC8 ASCL4 BMF C16orf45 C1orf109 C6orf165 CDKN2C CRCP CREBBP DGCR6 EDRF1 EP300 HAND1 HEXIM2 HOPX ID1 ID2 ID3 LYSMD1 MAPKBP1 MLLT6 MORN4 MSC NAGK NEUROG3 OLIG3 OSGIN1 PRSS23 PSMA1 PTF1A QARS RNASEL RUNX1T1 SOX10 SOX8 SPG21 SRI STAT5A STK16 TAF4 TAL2 TBP TCF23 TCF3 TRIM72 TSNAX TWIST2 VPS28	11 interactors: AAMP CCDC27 CCNDBP1 KAT2B RBPJ RPGRIP1 SPATA7 TCF12 TCF4 TRIP12 ZW10
Entrez ID		6938	256297
HPRD ID		02725	09526
Ensembl ID		ENSG00000140262	ENSG00000168267
Uniprot IDs		B4E1W1 F5GY10 Q99081	Q7RTS3
PDB IDs		2KNH 4JOL
Enriched GO Terms of Interacting Partners?		Gene Expression Transcription, DNA-templated RNA Metabolic Process RNA Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Gene Expression Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process Cellular Macromolecule Biosynthetic Process Organ Development Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Multicellular Organismal Development Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Developmental Process Regulation Of Transcription, DNA-templated Nitrogen Compound Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process System Development Transcription From RNA Polymerase II Promoter Biosynthetic Process Anatomical Structure Development Regulation Of DNA Binding Regulation Of Binding Negative Regulation Of DNA Binding Positive Regulation Of Transcription, DNA-templated Muscle Organ Development Central Nervous System Development Regulation Of Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Muscle Structure Development Cell Differentiation Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Cell Differentiation Negative Regulation Of Binding Rhythmic Process Regulation Of Cellular Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity	Positive Regulation Of Gluconeogenesis Transcription Initiation From RNA Polymerase II Promoter Regulation Of Glycoprotein Biosynthetic Process DNA-templated Transcription, Initiation Positive Regulation Of Glucose Metabolic Process Myoblast Differentiation Regulation Of Gluconeogenesis Pituitary Gland Development Transcription From RNA Polymerase II Promoter Somatic Stem Cell Maintenance Regulation Of Cell Cycle Protein Localization To Photoreceptor Outer Segment Positive Regulation Of Canonical Wnt Signaling Pathway Involved In Cardiac Muscle Cell Fate Commitment Positive Regulation Of Ephrin Receptor Signaling Pathway Arterial Endothelial Cell Fate Commitment Epidermal Cell Fate Specification Protein Localization To Photoreceptor Connecting Cilium Regulation Of BMP Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter Diencephalon Development Negative Regulation Of Cell Cycle Regulation Of Organ Growth Histone H3-K9 Acetylation Regulation Of Protein ADP-ribosylation Blood Vessel Lumenization Catenin Import Into Nucleus Blood Vessel Endothelial Cell Fate Specification Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition Regulation Of Glucose Metabolic Process Muscle Structure Development Blood Vessel Development Protein Localization To Organelle Vasculature Development Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Negative Regulation Of Histone H2A K63-linked Ubiquitination Protein Localization To Nonmotile Primary Cilium N-terminal Peptidyl-lysine Acetylation Endothelial Cell Fate Specification Regulation Of Striated Muscle Tissue Development Notch Signaling Pathway Positive Regulation Of Transcription, DNA-templated Cell Cycle Regulation Of Histone Ubiquitination Negative Regulation Of Protein K63-linked Ubiquitination Maintenance Of DNA Repeat Elements Clara Cell Differentiation Cell Cycle Arrest Stem Cell Maintenance Regulation Of Carbohydrate Metabolic Process Interleukin-4 Secretion
Tagcloud ?		cadherin cascade cd91 connexin consistently crc drastically ectopic efficiently enhancement facilitated fibronectin gap hsp90alpha ikappabalpha ikkalpha ikks invasion junction knocked mesenchymal migration motifs outgrowths repressed rhsp90alpha secreted spherical spreading	anlage atohla augmentation cerebellar fertilization granule hepatocyte hpf inc klf8 kruppel lip met modulates morphants morpholino mosp neurobiol periodicals perturbed primordium purkinje rescued rhombic rhombomere substantially tectum wiley zebrafish
Tagcloud (Difference) ?		cadherin cascade cd91 connexin consistently crc drastically ectopic efficiently enhancement facilitated fibronectin gap hsp90alpha ikappabalpha ikkalpha ikks invasion junction knocked mesenchymal migration motifs outgrowths repressed rhsp90alpha secreted spherical spreading	anlage atohla augmentation cerebellar fertilization granule hepatocyte hpf inc klf8 kruppel lip met modulates morphants morpholino mosp neurobiol periodicals perturbed primordium purkinje rescued rhombic rhombomere substantially tectum wiley zebrafish
Tagcloud (Intersection) ?