HAND1 and HEY2

Number of citations of the paper that reports this interaction (PMID 10924525)
22

Data Source:
HPRD (two hybrid, in vitro)

		HAND1	HEY2
Gene Name		heart and neural crest derivatives expressed 1	hes-related family bHLH transcription factor with YRPW motif 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm RNA Polymerase II Transcription Factor Complex	Nucleus Nucleoplasm Cytoplasm Sin3 Complex Transcriptional Repressor Complex
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Transcription Factor Binding Enzyme Binding Identical Protein Binding Protein Homodimerization Activity BHLH Transcription Factor Binding Transcription Regulatory Region DNA Binding Protein Heterodimerization Activity	RNA Polymerase II Core Promoter Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transcription Factor Activity RNA Polymerase II Activating Transcription Factor Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transcription Factor Binding Microsatellite Binding Histone Deacetylase Binding Sequence-specific DNA Binding Protein Dimerization Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Angiogenesis Mesoderm Formation Blastocyst Development Trophectodermal Cell Differentiation Heart Looping Embryonic Heart Tube Formation Cardiac Left Ventricle Formation Cardiac Right Ventricle Formation Transcription From RNA Polymerase II Promoter Heart Development Embryonic Heart Tube Development Odontogenesis Of Dentin-containing Tooth Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Ventricular Cardiac Muscle Tissue Morphogenesis Cardiac Septum Morphogenesis Mesenchyme Development Cartilage Morphogenesis Trophoblast Giant Cell Differentiation Negative Regulation Of RNA Polymerase II Regulatory Region Sequence-specific DNA Binding	Negative Regulation Of Transcription From RNA Polymerase II Promoter Vasculogenesis Muscular Septum Morphogenesis Outflow Tract Morphogenesis Pulmonary Valve Morphogenesis Tricuspid Valve Morphogenesis Tricuspid Valve Formation Endocardial Cushion To Mesenchymal Transition Involved In Heart Valve Formation Cardiac Ventricle Morphogenesis Cardiac Left Ventricle Morphogenesis Cardiac Right Ventricle Morphogenesis Ventricular Trabecula Myocardium Morphogenesis Transcription From RNA Polymerase II Promoter Notch Signaling Pathway Anterior/posterior Axis Specification Positive Regulation Of Heart Rate Negative Regulation Of Transcription By Transcription Factor Localization Negative Regulation Of Gene Expression Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Mesenchymal Cell Development Cardiac Muscle Hypertrophy In Response To Stress Ascending Aorta Morphogenesis Dorsal Aorta Morphogenesis Umbilical Cord Morphogenesis Cell Fate Commitment Regulation Of Auditory Receptor Cell Differentiation Negative Regulation Of Notch Signaling Pathway Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Smooth Muscle Cell Differentiation Ventricular Cardiac Muscle Cell Development Positive Regulation Of Cardiac Muscle Cell Proliferation Cardiac Epithelial To Mesenchymal Transition Heart Trabecula Formation Cardiac Septum Morphogenesis Ventricular Septum Morphogenesis Atrial Septum Morphogenesis Negative Regulation Of Transcription Initiation From RNA Polymerase II Promoter Labyrinthine Layer Blood Vessel Development Arterial Endothelial Cell Differentiation Cardiac Vascular Smooth Muscle Cell Development Coronary Vasculature Morphogenesis Pulmonary Artery Morphogenesis Notch Signaling Involved In Heart Development Protein-DNA Complex Assembly Cochlea Development Vascular Smooth Muscle Cell Development Negative Regulation Of Transcription Regulatory Region DNA Binding Negative Regulation Of Cardiac Vascular Smooth Muscle Cell Differentiation Negative Regulation Of Transcription From RNA Polymerase II Promoter Involved In Smooth Muscle Cell Differentiation Regulation Of Vasculogenesis
Pathways			Signaling by NOTCH1 HD Domain Mutants in Cancer Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Signaling by NOTCH Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant NOTCH1 Intracellular Domain Regulates Transcription Signaling by NOTCH1 Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by NOTCH1 in Cancer Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Constitutive Signaling by NOTCH1 PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer
Drugs
Diseases
GWAS		Ventricular conduction ( 21076409)
Protein-Protein Interactions		13 interactors: ACHE FHL2 HAND2 HEY2 HEYL MEF2A MYOD1 PPP2R5D PRKACA PRKCA SRA1 TCF12 TCF3	12 interactors: ARNT ATXN1 HAND1 HAND2 HDAC1 HES1 NCOR1 PLSCR1 RBPMS SIN3A SIRT1 TRAF1
Entrez ID		9421	23493
HPRD ID		03871	05243
Ensembl ID		ENSG00000113196	ENSG00000135547
Uniprot IDs		O96004	Q5TF93 Q9UBP5
PDB IDs
Enriched GO Terms of Interacting Partners?		Muscle Structure Development Positive Regulation Of Cellular Biosynthetic Process Cell Differentiation Tissue Development Transcription From RNA Polymerase II Promoter Muscle Organ Development Developmental Process Organ Development Cardiac Chamber Development System Development Regulation Of Cell Differentiation Outflow Tract Morphogenesis Gene Expression Multicellular Organismal Development Cell Development Positive Regulation Of Cellular Metabolic Process Cardiac Ventricle Morphogenesis Anatomical Structure Development Ventricular Cardiac Muscle Cell Development Heart Morphogenesis Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Cell Differentiation Cardiovascular System Development Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Dense Core Granule Biogenesis Cardiac Ventricle Development Positive Regulation Of Gene Expression Ventricular Cardiac Muscle Cell Differentiation Regulation Of Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Nervous System Development Transcription, DNA-templated Anatomical Structure Formation Involved In Morphogenesis Striated Muscle Tissue Development Stem Cell Differentiation Muscle Cell Differentiation RNA Biosynthetic Process Muscle Tissue Development Tissue Morphogenesis Cardiocyte Differentiation Positive Regulation Of Metabolic Process Mesenchymal Cell Differentiation Heart Valve Morphogenesis Histone H3-T6 Phosphorylation Heart Valve Development Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Muscle Cell Differentiation Striated Muscle Cell Development Cellular Macromolecule Biosynthetic Process Biosynthetic Process	Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process RNA Metabolic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of Gene Expression Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Signal Transduction Regulation Of Signaling Regulation Of DNA Binding Nucleobase-containing Compound Metabolic Process Regulation Of Transcription Regulatory Region DNA Binding Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Chromatin Silencing Negative Regulation Of Gene Expression Regulation Of Metabolic Process Nitrogen Compound Metabolic Process Negative Regulation Of Biosynthetic Process Organ Development Cardiac Right Ventricle Formation Negative Regulation Of DNA Binding In Utero Embryonic Development Histone Deacetylation Cardiac Neural Crest Cell Development Involved In Outflow Tract Morphogenesis Protein Deacetylation Embryonic Heart Tube Morphogenesis Regulation Of Binding Negative Regulation Of Gene Expression, Epigenetic Circadian Regulation Of Gene Expression
Tagcloud ?		accessible cardiogenesis cardiomyogenesis competence confers corepressors decommissioned dispensable divergence ectopic emerges enhancers epigenetically exclusive exploits fates gata4 hemogenic landscape mesoderm multipotent mutually occupying opposing orchestrated pioneer prevents primed recruiting	alterations anatomic astrocytoma astrocytomas biology braf grade hes1 hey1 implicated inhibiting interference much needed neoplastic notch notch1 notch2 overexpressed pa pas pediatric pilocytic res186 res259 secretase tumorigenesis variable viable
Tagcloud (Difference) ?		accessible cardiogenesis cardiomyogenesis competence confers corepressors decommissioned dispensable divergence ectopic emerges enhancers epigenetically exclusive exploits fates gata4 hemogenic landscape mesoderm multipotent mutually occupying opposing orchestrated pioneer prevents primed recruiting	alterations anatomic astrocytoma astrocytomas biology braf grade hes1 hey1 implicated inhibiting interference much needed neoplastic notch notch1 notch2 overexpressed pa pas pediatric pilocytic res186 res259 secretase tumorigenesis variable viable
Tagcloud (Intersection) ?