HAND1 and HEYL

Number of citations: 36 (PubMedID 10924525)
Data Source: HPRD (two hybrid, in vitro)

		HAND1	HEYL
Name		heart and neural crest derivatives expressed 1	hes related family bHLH transcription factor with YRPW motif like
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Nucleolus Cytoplasm RNA Polymerase II Transcription Regulator Complex	Chromatin Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Coregulator Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Enzyme Binding Identical Protein Binding Protein Homodimerization Activity BHLH Transcription Factor Binding Sequence-specific DNA Binding Protein Dimerization Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Homodimerization Activity Sequence-specific DNA Binding Protein Dimerization Activity AF-1 Domain Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Angiogenesis In Utero Embryonic Development Mesoderm Formation Blastocyst Development Trophectodermal Cell Differentiation Heart Looping Embryonic Heart Tube Formation Cardiac Left Ventricle Formation Cardiac Right Ventricle Formation Regulation Of Transcription By RNA Polymerase II Heart Development Cell Differentiation Embryonic Heart Tube Development Odontogenesis Of Dentin-containing Tooth Positive Regulation Of Transcription By RNA Polymerase II Ventricular Cardiac Muscle Tissue Morphogenesis Cardiac Septum Morphogenesis Mesenchyme Development Cartilage Morphogenesis Trophoblast Giant Cell Differentiation Determination Of Heart Left/right Asymmetry	Negative Regulation Of Transcription By RNA Polymerase II Outflow Tract Morphogenesis Aortic Valve Morphogenesis Atrioventricular Valve Morphogenesis Pulmonary Valve Morphogenesis Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Endocardial Cushion Morphogenesis Cardiac Ventricle Morphogenesis Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Notch Signaling Pathway Anatomical Structure Morphogenesis Anterior/posterior Pattern Specification Negative Regulation Of Gene Expression Mesenchymal Cell Development Glomerulus Development Skeletal Muscle Cell Differentiation Negative Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Neuron Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Neurogenesis Cardiac Epithelial To Mesenchymal Transition Ventricular Septum Morphogenesis Negative Regulation Of Androgen Receptor Signaling Pathway Cellular Response To BMP Stimulus Proximal Tubule Development Circulatory System Development
Pathways		Cardiogenesis	NOTCH1 Intracellular Domain Regulates Transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants NOTCH3 Intracellular Domain Regulates Transcription Regulation of CDH11 gene transcription Regulation of CDH11 gene transcription
GWAS		Chin dimples ( 27182965 ) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) Electrocardiographic traits (multivariate) ( 32602732 ) Global electrical heterogeneity phenotypes ( 29622589 ) Monobrow ( 27182965 ) QRS complex (Cornell) ( 27659466 ) QRS duration ( 25035420 27577874 30679814 31251759 )	HDL cholesterol levels ( 30698716 ) HDL cholesterol levels in current drinkers ( 30698716 ) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716 ) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716 ) Red blood cell traits ( 23222517 ) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716 ) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716 )
Interacting Genes		15 interacting genes: ACHE DNMT3L FHL2 HAND2 HEY2 HEYL KRTAP10-6 MEF2A MYOD1 PPP2R5D PRKACA PRKCA SRA1 TCF12 TCF3	22 interacting genes: APP ATF7IP ATXN1 BANP CFTR HAND1 HAND2 HIPK3 HTT KRTAP6-2 LAPTM5 MDFI PLEKHB2 PPP1CA RBPMS RPGRIP1 SKIL SMAD3 SMAD7 SMAD9 SP8 ZNF512B
Entrez ID		9421	26508
HPRD ID		03871	16419
Ensembl ID		ENSG00000113196	ENSG00000163909
Uniprot IDs		O96004	B4DU20 Q9NQ87
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Protein Dimerization Activity BHLH Transcription Factor Binding Positive Regulation Of Biosynthetic Process E-box Binding Positive Regulation Of Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity System Development DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of Macromolecule Biosynthetic Process Transcription Regulator Complex Regulation Of Cell Differentiation Nucleus Anatomical Structure Formation Involved In Morphogenesis Positive Regulation Of Cardiac Muscle Hypertrophy Cellular Developmental Process Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Positive Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Mesenchymal Cell Development Regulation Of Metabolic Process Chromatin Regulation Of Neuron Differentiation Outflow Tract Morphogenesis DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Developmental Process Regulation Of RNA Metabolic Process Striated Muscle Cell Development Ventricular Cardiac Muscle Cell Development Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Macromolecule Biosynthetic Process Coronary Vasculature Morphogenesis Positive Regulation Of Multicellular Organismal Process Sequence-specific DNA Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Biosynthetic Process Regulation Of Multicellular Organismal Process Regulation Of Muscle System Process Positive Regulation Of Transcription By RNA Polymerase II Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Heart Trabecula Formation Positive Regulation Of Neuron Differentiation Cell Differentiation Cell Development Positive Regulation Of RNA Metabolic Process Muscle Cell Development	SMAD Protein Signal Transduction Heteromeric SMAD Protein Complex Anatomical Structure Morphogenesis Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Transcription Regulator Complex Negative Regulation Of Biosynthetic Process I-SMAD Binding Negative Regulation Of Metabolic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Protein-containing Complex Negative Regulation Of RNA Metabolic Process Identical Protein Binding Negative Regulation Of MiRNA Transcription Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Primary Metabolic Process Nucleus Transforming Growth Factor Beta Receptor Signaling Pathway Cardiac Right Ventricle Formation Enzyme Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Embryonic Morphogenesis Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Regulation Of Gene Expression SMAD Protein Complex Determination Of Heart Left/right Asymmetry Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Apoptotic Signaling Pathway Tube Morphogenesis Cardiac Ventricle Formation Animal Organ Morphogenesis Regulation Of Nucleobase-containing Compound Metabolic Process Response To Growth Factor Regulation Of Extrinsic Apoptotic Signaling Pathway Cartilage Morphogenesis Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Programmed Cell Death Positive Regulation Of Programmed Cell Death Heart Looping Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cardiac Chamber Formation Odontogenesis Of Dentin-containing Tooth Embryonic Heart Tube Morphogenesis Nucleoplasm