HAND1 and HEYL

Number of citations of the paper that reports this interaction (PMID 10924525)
22

Data Source:
HPRD (two hybrid, in vitro)

		HAND1	HEYL
Gene Name		heart and neural crest derivatives expressed 1	hes-related family bHLH transcription factor with YRPW motif-like
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm RNA Polymerase II Transcription Factor Complex	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Transcription Factor Binding Enzyme Binding Identical Protein Binding Protein Homodimerization Activity BHLH Transcription Factor Binding Transcription Regulatory Region DNA Binding Protein Heterodimerization Activity	RNA Polymerase II Core Promoter Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transcription Factor Activity RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription RNA Polymerase II Transcription Corepressor Activity Sequence-specific DNA Binding Transcription Factor Activity Transcription Corepressor Activity Protein Binding Transcription Factor Binding Microsatellite Binding Protein Homodimerization Activity Protein Heterodimerization Activity AF-1 Domain Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Angiogenesis Mesoderm Formation Blastocyst Development Trophectodermal Cell Differentiation Heart Looping Embryonic Heart Tube Formation Cardiac Left Ventricle Formation Cardiac Right Ventricle Formation Transcription From RNA Polymerase II Promoter Heart Development Embryonic Heart Tube Development Odontogenesis Of Dentin-containing Tooth Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Ventricular Cardiac Muscle Tissue Morphogenesis Cardiac Septum Morphogenesis Mesenchyme Development Cartilage Morphogenesis Trophoblast Giant Cell Differentiation Negative Regulation Of RNA Polymerase II Regulatory Region Sequence-specific DNA Binding	Outflow Tract Morphogenesis Atrioventricular Valve Morphogenesis Pulmonary Valve Morphogenesis Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Endocardial Cushion Morphogenesis Cardiac Ventricle Morphogenesis Transcription From RNA Polymerase II Promoter Notch Signaling Pathway Mesenchymal Cell Development Glomerulus Development Skeletal Muscle Cell Differentiation Positive Regulation Of Neuron Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Cardiac Epithelial To Mesenchymal Transition Ventricular Septum Morphogenesis Negative Regulation Of Androgen Receptor Signaling Pathway Cellular Response To BMP Stimulus Proximal Tubule Development Negative Regulation Of Androgen Receptor Activity
Pathways			Signaling by NOTCH1 HD Domain Mutants in Cancer Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Signaling by NOTCH Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant NOTCH1 Intracellular Domain Regulates Transcription Signaling by NOTCH1 Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by NOTCH1 in Cancer Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Constitutive Signaling by NOTCH1 PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer
Drugs
Diseases
GWAS		Ventricular conduction ( 21076409)	Red blood cell traits ( 23222517)
Protein-Protein Interactions		13 interactors: ACHE FHL2 HAND2 HEY2 HEYL MEF2A MYOD1 PPP2R5D PRKACA PRKCA SRA1 TCF12 TCF3	18 interactors: APP ATF7IP ATXN1 HAND1 HAND2 HIPK3 HTT LAPTM5 MDFI PPP1CA RBPMS RPGRIP1 SKIL SMAD3 SMAD7 SMAD9 SP8 ZNF512B
Entrez ID		9421	26508
HPRD ID		03871	16419
Ensembl ID		ENSG00000113196	ENSG00000163909
Uniprot IDs		O96004	F5H3V9 Q9NQ87
PDB IDs
Enriched GO Terms of Interacting Partners?		Muscle Structure Development Positive Regulation Of Cellular Biosynthetic Process Cell Differentiation Tissue Development Transcription From RNA Polymerase II Promoter Muscle Organ Development Developmental Process Organ Development Cardiac Chamber Development System Development Regulation Of Cell Differentiation Outflow Tract Morphogenesis Gene Expression Multicellular Organismal Development Cell Development Positive Regulation Of Cellular Metabolic Process Cardiac Ventricle Morphogenesis Anatomical Structure Development Ventricular Cardiac Muscle Cell Development Heart Morphogenesis Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Cell Differentiation Cardiovascular System Development Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Dense Core Granule Biogenesis Cardiac Ventricle Development Positive Regulation Of Gene Expression Ventricular Cardiac Muscle Cell Differentiation Regulation Of Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Nervous System Development Transcription, DNA-templated Anatomical Structure Formation Involved In Morphogenesis Striated Muscle Tissue Development Stem Cell Differentiation Muscle Cell Differentiation RNA Biosynthetic Process Muscle Tissue Development Tissue Morphogenesis Cardiocyte Differentiation Positive Regulation Of Metabolic Process Mesenchymal Cell Differentiation Heart Valve Morphogenesis Histone H3-T6 Phosphorylation Heart Valve Development Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Muscle Cell Differentiation Striated Muscle Cell Development Cellular Macromolecule Biosynthetic Process Biosynthetic Process	Regulation Of Gene Expression Transcription, DNA-templated RNA Biosynthetic Process Anatomical Structure Morphogenesis RNA Metabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Organ Development Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Transforming Growth Factor Beta Stimulus Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Response To Transforming Growth Factor Beta Heterocycle Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Tube Development Epithelium Development Negative Regulation Of Signal Transduction Positive Regulation Of Gene Expression Regulation Of Metabolic Process Regulation Of Signal Transduction Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Pattern Specification Process Negative Regulation Of Signaling Regulation Of Binding Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Cellular Macromolecule Biosynthetic Process Negative Regulation Of Cellular Response To Growth Factor Stimulus Macromolecule Biosynthetic Process Tissue Development Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of Signaling Positive Regulation Of Transcription, DNA-templated Multicellular Organismal Development Cellular Aromatic Compound Metabolic Process Biosynthetic Process Cardiac Right Ventricle Formation Anatomical Structure Development Positive Regulation Of Cellular Metabolic Process Organ Morphogenesis Negative Regulation Of DNA Binding Embryonic Morphogenesis System Development
Tagcloud ?		accessible cardiogenesis cardiomyogenesis competence confers corepressors decommissioned dispensable divergence ectopic emerges enhancers epigenetically exclusive exploits fates gata4 hemogenic landscape mesoderm multipotent mutually occupying opposing orchestrated pioneer prevents primed recruiting	bad bromide cancerous dimethylthiazol diphenyltetrazolium egfp eighty expressional hairy hcc hep hypermethylation inactivated lentiviral overexpress p19 pheyl preceded qpcr repressor resected ribose shheyl silence sk split surgically yrpw
Tagcloud (Difference) ?		accessible cardiogenesis cardiomyogenesis competence confers corepressors decommissioned dispensable divergence ectopic emerges enhancers epigenetically exclusive exploits fates gata4 hemogenic landscape mesoderm multipotent mutually occupying opposing orchestrated pioneer prevents primed recruiting	bad bromide cancerous dimethylthiazol diphenyltetrazolium egfp eighty expressional hairy hcc hep hypermethylation inactivated lentiviral overexpress p19 pheyl preceded qpcr repressor resected ribose shheyl silence sk split surgically yrpw
Tagcloud (Intersection) ?