HAND1

Gene Name		heart and neural crest derivatives expressed 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm RNA Polymerase II Transcription Factor Complex
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Transcription Factor Binding Enzyme Binding Identical Protein Binding Protein Homodimerization Activity BHLH Transcription Factor Binding Transcription Regulatory Region DNA Binding Protein Heterodimerization Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Angiogenesis Mesoderm Formation Blastocyst Development Trophectodermal Cell Differentiation Heart Looping Embryonic Heart Tube Formation Cardiac Left Ventricle Formation Cardiac Right Ventricle Formation Transcription From RNA Polymerase II Promoter Heart Development Embryonic Heart Tube Development Odontogenesis Of Dentin-containing Tooth Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Ventricular Cardiac Muscle Tissue Morphogenesis Cardiac Septum Morphogenesis Mesenchyme Development Cartilage Morphogenesis Trophoblast Giant Cell Differentiation Negative Regulation Of RNA Polymerase II Regulatory Region Sequence-specific DNA Binding
Pathways
Drugs
Diseases
GWAS		Ventricular conduction ( 21076409)
Protein-protein Interactions		13 interactors: ACHE FHL2 HAND2 HEY2 HEYL MEF2A MYOD1 PPP2R5D PRKACA PRKCA SRA1 TCF12 TCF3
Entrez ID		9421
HPRD ID		03871
Ensembl ID		ENSG00000113196
Uniprot IDs		O96004
PDB IDs
Enriched GO Terms of Interacting Partners?		Muscle Structure Development Positive Regulation Of Cellular Biosynthetic Process Cell Differentiation Tissue Development Transcription From RNA Polymerase II Promoter Muscle Organ Development Developmental Process Organ Development Cardiac Chamber Development System Development Regulation Of Cell Differentiation Outflow Tract Morphogenesis Gene Expression Multicellular Organismal Development Cell Development Positive Regulation Of Cellular Metabolic Process Cardiac Ventricle Morphogenesis Anatomical Structure Development Ventricular Cardiac Muscle Cell Development Heart Morphogenesis Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Cell Differentiation Cardiovascular System Development Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Dense Core Granule Biogenesis Cardiac Ventricle Development Positive Regulation Of Gene Expression Ventricular Cardiac Muscle Cell Differentiation Regulation Of Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Nervous System Development Transcription, DNA-templated Anatomical Structure Formation Involved In Morphogenesis Striated Muscle Tissue Development Stem Cell Differentiation Muscle Cell Differentiation RNA Biosynthetic Process Muscle Tissue Development Tissue Morphogenesis Cardiocyte Differentiation Positive Regulation Of Metabolic Process Mesenchymal Cell Differentiation Heart Valve Morphogenesis Histone H3-T6 Phosphorylation Heart Valve Development Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Muscle Cell Differentiation Striated Muscle Cell Development Cellular Macromolecule Biosynthetic Process Biosynthetic Process
Tagcloud ?		accessible cardiogenesis cardiomyogenesis competence confers corepressors decommissioned dispensable divergence ectopic emerges enhancers epigenetically exclusive exploits fates gata4 hemogenic landscape mesoderm multipotent mutually occupying opposing orchestrated pioneer prevents primed recruiting