HAND1 and HAND2

Number of citations: 36 (PubMedID 10924525)
Data Source: HPRD (in vitro)

		HAND1	HAND2
Name		heart and neural crest derivatives expressed 1	heart and neural crest derivatives expressed 2
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Nucleolus Cytoplasm RNA Polymerase II Transcription Regulator Complex	Chromatin Nucleus Transcription Regulator Complex Protein-containing Complex
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Coregulator Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Enzyme Binding Identical Protein Binding Protein Homodimerization Activity BHLH Transcription Factor Binding Sequence-specific DNA Binding Protein Dimerization Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Coactivator Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Minor Groove Of Adenine-thymine-rich DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Homodimerization Activity Sequence-specific DNA Binding Protein Dimerization Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding E-box Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Angiogenesis In Utero Embryonic Development Mesoderm Formation Blastocyst Development Trophectodermal Cell Differentiation Heart Looping Embryonic Heart Tube Formation Cardiac Left Ventricle Formation Cardiac Right Ventricle Formation Regulation Of Transcription By RNA Polymerase II Heart Development Cell Differentiation Embryonic Heart Tube Development Odontogenesis Of Dentin-containing Tooth Positive Regulation Of Transcription By RNA Polymerase II Ventricular Cardiac Muscle Tissue Morphogenesis Cardiac Septum Morphogenesis Mesenchyme Development Cartilage Morphogenesis Trophoblast Giant Cell Differentiation Determination Of Heart Left/right Asymmetry	Angiogenesis Osteoblast Differentiation In Utero Embryonic Development Heart Looping Suckling Behavior Heart Morphogenesis Outflow Tract Morphogenesis Cardiac Right Ventricle Formation Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Regulation Of Secondary Heart Field Cardioblast Proliferation Apoptotic Process Involved In Heart Morphogenesis Noradrenergic Neuron Differentiation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Apoptotic Process Heart Development Adult Heart Development Mesenchymal Cell Proliferation Positive Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Neural Crest Cell Development Cell Differentiation Regulation Of Tissue Remodeling Norepinephrine Biosynthetic Process Odontogenesis Of Dentin-containing Tooth Embryonic Digit Morphogenesis Tongue Development Negative Regulation Of Osteoblast Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Sympathetic Nervous System Development Thymus Development Embryonic Skeletal System Development Peripheral Nervous System Neuron Development Roof Of Mouth Development Mesenchyme Development Cartilage Morphogenesis Coronary Artery Morphogenesis Visceral Serous Pericardium Development Cardiac Neural Crest Cell Development Involved In Outflow Tract Morphogenesis Cell Proliferation Involved In Outflow Tract Morphogenesis Determination Of Heart Left/right Asymmetry Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Retinoic Acid Positive Regulation Of P38MAPK Cascade Primary Palate Development Epithelial Cell Apoptotic Process Negative Regulation Of Epithelial Cell Apoptotic Process Positive Regulation Of Semaphorin-plexin Signaling Pathway
Pathways		Cardiogenesis	Transcriptional regulation by RUNX2 Cardiogenesis
GWAS		Chin dimples ( 27182965 ) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) Electrocardiographic traits (multivariate) ( 32602732 ) Global electrical heterogeneity phenotypes ( 29622589 ) Monobrow ( 27182965 ) QRS complex (Cornell) ( 27659466 ) QRS duration ( 25035420 27577874 30679814 31251759 )	Atrial fibrillation ( 28416822 29892015 30061737 33990960 ) Chin dimples ( 27182965 ) Early onset atrial fibrillation ( 28460022 ) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) Epstein-Barr virus copy number in lymphoblastoid cell lines ( 28654678 ) PR interval ( 32439900 )
Interacting Genes		15 interacting genes: ACHE DNMT3L FHL2 HAND2 HEY2 HEYL KRTAP10-6 MEF2A MYOD1 PPP2R5D PRKACA PRKCA SRA1 TCF12 TCF3	19 interacting genes: CENPB COPS5 DNMT3L EP300 FAM90A1 GATA4 HAND1 HEY2 HEYL KANK2 NPM1 PHOX2A PPP2R5D PRKACA PRKCA RIPPLY1 SPANXN3 TCF3 USP20
Entrez ID		9421	9464
HPRD ID		03871	03872
Ensembl ID		ENSG00000113196	ENSG00000164107
Uniprot IDs		O96004	P61296
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Protein Dimerization Activity BHLH Transcription Factor Binding Positive Regulation Of Biosynthetic Process E-box Binding Positive Regulation Of Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity System Development DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of Macromolecule Biosynthetic Process Transcription Regulator Complex Regulation Of Cell Differentiation Nucleus Anatomical Structure Formation Involved In Morphogenesis Positive Regulation Of Cardiac Muscle Hypertrophy Cellular Developmental Process Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Positive Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Mesenchymal Cell Development Regulation Of Metabolic Process Chromatin Regulation Of Neuron Differentiation Outflow Tract Morphogenesis DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Developmental Process Regulation Of RNA Metabolic Process Striated Muscle Cell Development Ventricular Cardiac Muscle Cell Development Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Macromolecule Biosynthetic Process Coronary Vasculature Morphogenesis Positive Regulation Of Multicellular Organismal Process Sequence-specific DNA Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Biosynthetic Process Regulation Of Multicellular Organismal Process Regulation Of Muscle System Process Positive Regulation Of Transcription By RNA Polymerase II Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Heart Trabecula Formation Positive Regulation Of Neuron Differentiation Cell Differentiation Cell Development Positive Regulation Of RNA Metabolic Process Muscle Cell Development	Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Biosynthetic Process Cardiac Septum Morphogenesis Regulation Of DNA-binding Transcription Factor Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Pattern Specification Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of Macromolecule Metabolic Process Cardiac Ventricle Morphogenesis Positive Regulation Of DNA-binding Transcription Factor Activity Aortic Valve Morphogenesis Negative Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Chromatin Positive Regulation Of Metabolic Process Anatomical Structure Formation Involved In Morphogenesis Regulation Of Transcription By RNA Polymerase II Atrioventricular Valve Formation Mesenchymal Cell Development Positive Regulation Of Macromolecule Biosynthetic Process Anterior/posterior Pattern Specification Heart Valve Morphogenesis Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Cell Fate Commitment DNA-binding Transcription Factor Binding Protein Dimerization Activity Nucleoplasm DNA-binding Transcription Factor Activity Regulation Of Gene Expression Positive Regulation Of RNA Metabolic Process Cardiac Right Ventricle Morphogenesis Heart Valve Formation Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Macromolecule Biosynthetic Process Nucleus System Development Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Cis-regulatory Region Sequence-specific DNA Binding Tissue Development