HAND1 and TCF3

Number of citations of the paper that reports this interaction (PubMedID 11802795)
46

Data Source:
HPRD (in vitro)

		HAND1	TCF3
Description		heart and neural crest derivatives expressed 1	transcription factor 3
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Nucleolus Cytoplasm RNA Polymerase II Transcription Regulator Complex	Chromatin Euchromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Protein-containing Complex RNA Polymerase II Transcription Regulator Complex
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Coregulator Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Enzyme Binding Identical Protein Binding Protein Homodimerization Activity BHLH Transcription Factor Binding Sequence-specific DNA Binding Protein Dimerization Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Mitogen-activated Protein Kinase Kinase Kinase Binding Protein Homodimerization Activity BHLH Transcription Factor Binding Protein Heterodimerization Activity Protein Dimerization Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Vitamin D Response Element Binding E-box Binding DNA-binding Transcription Factor Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Angiogenesis In Utero Embryonic Development Mesoderm Formation Blastocyst Development Trophectodermal Cell Differentiation Heart Looping Embryonic Heart Tube Formation Cardiac Left Ventricle Formation Cardiac Right Ventricle Formation Regulation Of Transcription By RNA Polymerase II Heart Development Cell Differentiation Embryonic Heart Tube Development Odontogenesis Of Dentin-containing Tooth Positive Regulation Of Transcription By RNA Polymerase II Ventricular Cardiac Muscle Tissue Morphogenesis Cardiac Septum Morphogenesis Mesenchyme Development Cartilage Morphogenesis Trophoblast Giant Cell Differentiation Determination Of Heart Left/right Asymmetry	Negative Regulation Of Transcription By RNA Polymerase II B Cell Lineage Commitment Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Nervous System Development Cell Differentiation B Cell Differentiation Positive Regulation Of B Cell Proliferation Immunoglobulin V(D)J Recombination Positive Regulation Of Neuron Differentiation Positive Regulation Of Cell Cycle Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA-binding Transcription Factor Activity Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		Cardiogenesis	Myogenesis Myogenesis RUNX1 regulates transcription of genes involved in differentiation of HSCs Negative Regulation of CDH1 Gene Transcription TGFBR3 expression
Drugs
Diseases			Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia)
GWAS		Chin dimples ( 27182965) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic traits (multivariate) ( 32602732) Global electrical heterogeneity phenotypes ( 29622589) Monobrow ( 27182965) QRS complex (Cornell) ( 27659466) QRS duration ( 25035420 27577874 30679814 31251759)	Hodgkin's lymphoma ( 24920014 29196614) Monocyte count ( 32888494) Objective response to lithium treatment ( 26503763) Triglyceride levels ( 34074324)
Interacting Genes		15 interacting genes: ACHE DNMT3L FHL2 HAND2 HEY2 HEYL KRTAP10-6 MEF2A MYOD1 PPP2R5D PRKACA PRKCA SRA1 TCF12 TCF3	66 interacting genes: AEBP1 ASCL3 AURKA BHLHA15 BHLHE40 CALM1 CALM3 CBFA2T3 CREBBP CTNNB1 DACH1 DAXX ELK3 EP300 FERD3L GLIS1 HAND1 HAND2 HOXA1 ID1 ID2 ID3 KAT2A KAT2B LMX1A LMX1B LYL1 MAPK1 MAPK3 MAPKAPK2 MAPKAPK3 MDFI MEN1 MSC MYF5 MYF6 MYOD1 MYOG NEDD9 NEUROD1 NHLH1 NSD3 PARP1 PDX1 PSMD4 PSMD9 RALGAPA1 RPL37 RUNX1T1 SCX SKP2 SRF SUPT3H TADA2A TAL1 TAL2 TCAF1 TCF12 TCF21 TCF4 TFPT TLE1 TRRAP TWIST1 UBE2I USF1
Entrez ID		9421	6929
HPRD ID		03871	00918
Ensembl ID		ENSG00000113196	ENSG00000071564
Uniprot IDs		O96004	P15923
PDB IDs			2MH0 2YPA 2YPB 3U5V 6MGN
Enriched GO Terms of Interacting Partners?		Protein Dimerization Activity BHLH Transcription Factor Binding Positive Regulation Of Biosynthetic Process E-box Binding Positive Regulation Of Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity System Development DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of Macromolecule Biosynthetic Process Transcription Regulator Complex Regulation Of Cell Differentiation Nucleus Anatomical Structure Formation Involved In Morphogenesis Positive Regulation Of Cardiac Muscle Hypertrophy Cellular Developmental Process Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Positive Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Mesenchymal Cell Development Regulation Of Metabolic Process Chromatin Regulation Of Neuron Differentiation Outflow Tract Morphogenesis DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Developmental Process Regulation Of RNA Metabolic Process Striated Muscle Cell Development Ventricular Cardiac Muscle Cell Development Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Macromolecule Biosynthetic Process Coronary Vasculature Morphogenesis Positive Regulation Of Multicellular Organismal Process Sequence-specific DNA Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Biosynthetic Process Regulation Of Multicellular Organismal Process Regulation Of Muscle System Process Positive Regulation Of Transcription By RNA Polymerase II Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Heart Trabecula Formation Positive Regulation Of Neuron Differentiation Cell Differentiation Cell Development Positive Regulation Of RNA Metabolic Process Muscle Cell Development	Protein Dimerization Activity Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Chromatin Regulation Of Primary Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Metabolic Process Regulation Of Gene Expression Nucleus Positive Regulation Of Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process E-box Binding Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process DNA Binding BHLH Transcription Factor Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Negative Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Regulator Complex RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Nucleoplasm Sequence-specific Double-stranded DNA Binding Negative Regulation Of Transcription By RNA Polymerase II RNA Polymerase II-specific DNA-binding Transcription Factor Binding DNA-binding Transcription Factor Activity Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Cell Differentiation Negative Regulation Of Metabolic Process Cell Differentiation Animal Organ Development RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Developmental Process Animal Organ Morphogenesis Regulation Of Developmental Process Embryonic Morphogenesis
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