TCF12 and NEUROG1

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		TCF12	NEUROG1
Description		transcription factor 12	neurogenin 1
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Nuclear Speck RNA Polymerase II Transcription Regulator Complex	Chromatin Nucleus Neuronal Cell Body Perikaryon
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding CAMP Response Element Binding BHLH Transcription Factor Binding SMAD Binding Protein Heterodimerization Activity Protein Dimerization Activity E-box Binding HMG Box Domain Binding DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Protein Homodimerization Activity Protein Dimerization Activity E-box Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Immune Response Nervous System Development Muscle Organ Development Gene Expression Positive Regulation Of Gene Expression Cell Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Response To Gonadotropin-releasing Hormone	Regulation Of Transcription By RNA Polymerase II Thorax And Anterior Abdomen Determination Nervous System Development Sensory Organ Development Exit From Mitosis Trigeminal Nerve Development Vestibulocochlear Nerve Formation Neurogenesis Cell Differentiation Neuron Differentiation Peristalsis Forebrain Development Auditory Behavior Positive Regulation Of Exit From Mitosis Genitalia Morphogenesis Inner Ear Morphogenesis Cell Fate Commitment Regulation Of Neuron Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Muscle Organ Development Genitalia Development Inner Ear Development Neuromuscular Process Controlling Balance Positive Regulation Of DNA-binding Transcription Factor Activity Axon Development Mastication Cochlea Development Cochlea Morphogenesis Craniofacial Suture Morphogenesis Learned Vocalization Behavior Negative Regulation Of Relaxation Of Muscle Negative Regulation Of Saliva Secretion Hard Palate Morphogenesis
Pathways		Myogenesis Myogenesis RUNX1 regulates transcription of genes involved in differentiation of HSCs NGF-stimulated transcription NGF-stimulated transcription Negative Regulation of CDH1 Gene Transcription TGFBR3 expression
Drugs
Diseases
GWAS		3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Alcohol consumption (drinks per week) ( 30643258) Apolipoprotein B levels ( 32203549) Body mass index ( 28892062) Glaucoma (primary open-angle) ( 29891935 33627673) LDL cholesterol levels ( 32203549) Low density lipoprotein cholesterol levels ( 32154731) Male-pattern baldness ( 28196072) Mean platelet volume ( 27863252 32888494) Triglyceride levels ( 32154731) Type 2 diabetes ( 30297969)
Interacting Genes		68 interacting genes: AIRIM ARL16 ARMC8 ASCL4 BMERB1 BMF CDKN2C CFAP206 CKS1B CLCNKA CRCP CREBBP DDX6 DGCR6 EDRF1 EP300 EXOC8 FRMD6 GRB7 HAND1 HOPX ID1 ID2 ID3 LAMTOR5 LNX1 LYSMD1 MAPKBP1 MLLT6 MORN4 MSC MYF6 MYO15B NAGK NEK6 NEUROD1 NEUROG1 NGLY1 NHLH2 OLIG3 OSGIN1 PIN1 PRKAB2 PRSS23 PSMA1 PTF1A QARS1 RBM8A RNASEL RUNX1T1 SOX10 SOX8 SPG21 SRI STAT5A STK16 TAF4 TAL2 TBC1D21 TBP TCF21 TCF3 TMEM132D TRIM72 TSNAX VPS28 WTAP ZNF688	7 interacting genes: CBFA2T2 CREBBP RUNX1T1 SMAD1 TARBP2 TCF12 TCF4
Entrez ID		6938	4762
HPRD ID		02725	03430
Ensembl ID		ENSG00000140262	ENSG00000181965
Uniprot IDs		F5GY10 Q99081	F1T0H3 Q92886
PDB IDs		2KNH 4JOL
Enriched GO Terms of Interacting Partners?		Protein Dimerization Activity Chromatin DNA-binding Transcription Factor Binding E-box Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Cell Fate Commitment Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Positive Regulation Of RNA Metabolic Process Animal Organ Development Regulation Of Macromolecule Biosynthetic Process Neuron Differentiation BHLH Transcription Factor Binding Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Regulator Complex Positive Regulation Of Nucleobase-containing Compound Metabolic Process Histone H3K27 Acetyltransferase Activity Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Biosynthetic Process Nucleus Regulation Of Metabolic Process RNA Polymerase II Transcription Regulator Complex Striated Muscle Tissue Development Transcription Regulator Inhibitor Activity Nucleoplasm Regulation Of Macromolecule Metabolic Process Tau Protein Binding Oligodendrocyte Differentiation Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Histone H3K18 Acetyltransferase Activity N-terminal Peptidyl-lysine Acetylation Peptide Lactyltransferase (CoA-dependent) Activity Thigmotaxis Branchiomeric Skeletal Muscle Development Muscle Tissue Development Cytoplasm Negative Regulation Of Macromolecule Biosynthetic Process Cell Differentiation DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Developmental Process	Transcription Regulator Complex Transcription Corepressor Activity DNA-binding Transcription Factor Binding MiRNA Processing Nucleoplasm Regulation Of Cell Differentiation E-box Binding DNA-templated Transcription Regulation Of Macromolecule Biosynthetic Process Regulation Of DNA-templated Transcription Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Nucleic Acid Metabolic Process Nucleus Histone H3K27 Acetyltransferase Activity Chromatin Homomeric SMAD Protein Complex DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of Cell Differentiation Regulation Of SiRNA Processing Positive Regulation Of Neuron Differentiation Regulation Of RNA Metabolic Process Histone H3K18 Acetyltransferase Activity N-terminal Peptidyl-lysine Acetylation Peptide Lactyltransferase (CoA-dependent) Activity Mesodermal Cell Fate Commitment Osteoblast Fate Commitment Global Gene Silencing By MRNA Cleavage Beta-catenin-TCF7L2 Complex Mpp10 Complex Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Developmental Process Negative Regulation Of Defense Response To Virus By Host TFIIB-class Transcription Factor Binding RNA Metabolic Process Regulation Of Developmental Process MRF Binding Regulation Of Transcription By RNA Polymerase II Regulation Of Muscle Cell Differentiation Positive Regulation Of Neuron Projection Development Anti-Mullerian Hormone Receptor Signaling Pathway Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Factor Activity Protein Dimerization Activity
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