FADS2 and ATXN1L

Number of citations of the paper that reports this interaction (PMID 16713569)
214

Data Source:
BioGRID (two hybrid)

		FADS2	ATXN1L
Gene Name		fatty acid desaturase 2	ataxin 1-like
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Membrane Integral Component Of Plasma Membrane Membrane	Nucleus Nucleolus Dendrite
	Molecular Function	Stearoyl-CoA 9-desaturase Activity Iron Ion Binding Heme Binding	DNA Binding RNA Binding Protein Binding
	Biological Process	Unsaturated Fatty Acid Biosynthetic Process Unsaturated Fatty Acid Metabolic Process Alpha-linolenic Acid Metabolic Process Linoleic Acid Metabolic Process Small Molecule Metabolic Process Oxidation-reduction Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Extracellular Matrix Organization Lung Alveolus Development Positive Regulation Of Hematopoietic Stem Cell Proliferation
Pathways		Metabolism of lipids and lipoproteins alpha-linolenic acid (ALA) metabolism alpha-linolenic (omega3) and linoleic (omega6) acid metabolism Linoleic acid (LA) metabolism
Drugs
Diseases
GWAS		Cholesterol, total ( 19060911 20686565) Comprehensive strength and appendicular lean mass ( 22960237) HDL cholesterol ( 19060906 19060911 20686565) Inflammatory bowel disease ( 23128233) LDL cholesterol ( 19060910 19060911 20686565) Lipid metabolism phenotypes ( 22286219) Liver enzyme levels (alkaline phosphatase) ( 22001757) Metabolic syndrome ( 20694148) Metabolite levels ( 23378610 22916037) Oleic acid (18:1n-9) plasma levels ( 23362303) Palmitoleic acid (16:1n-7) plasma levels ( 23362303) Phospholipid levels (plasma) ( 21829377 22359512) Response to statin therapy ( 20339536) Sphingolipid levels ( 22359512) Stearic acid (18:0) plasma levels ( 23362303) Triglycerides ( 19060906 20686565)
Protein-Protein Interactions		1 interactors: ATXN1L	57 interactors: ACO2 ACOT7 ADORA1 AFAP1L2 ALG13 ANKHD1 AP1G2 AP2M1 APBB1 ATXN1 CAMSAP2 CBFA2T2 CHD6 COIL CTBP1 DAB2 DAZAP2 EPB41L2 EPB41L3 FADS2 FUS GAS7 GMEB2 GORASP2 GPATCH8 H2AFY HGS HIVEP1 HSFX1 MATN2 MBD1 MBD6 MEOX2 METTL17 NBR1 NCOR1 NCOR2 NIT1 PHPT1 PICK1 PRRC2B RAD54L2 RBFOX2 RRAGC SCAF11 SMARCC2 SREBF1 ST6GALNAC6 STAC2 SUGP2 THY1 TMEM25 TMEM8B TRIP11 YY1AP1 ZC3H7B ZSWIM8
Entrez ID		9415	342371
HPRD ID		05854	19555
Ensembl ID		ENSG00000134824	ENSG00000224470
Uniprot IDs		B7Z634 O95864	P0C7T5
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Hematopoietic Stem Cell Proliferation Regulation Of Hematopoietic Stem Cell Proliferation	Negative Regulation Of Transcription, DNA-templated Gene Expression Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process RNA Metabolic Process Positive Regulation Of Histone Deacetylation Transcription, DNA-templated Negative Regulation Of Gene Expression RNA Biosynthetic Process Positive Regulation Of Protein Deacetylation Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Cellular Component Organization Regulation Of RNA Metabolic Process Regulation Of ERBB Signaling Pathway Regulation Of Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of Histone Deacetylation Cellular Macromolecule Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Macromolecule Biosynthetic Process Regulation Of Metabolic Process Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Negative Regulation Of Signaling Regulation Of Histone Modification Regulation Of Protein Deacetylation Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Cellular Nitrogen Compound Metabolic Process Cellular Response To Starvation Negative Regulation Of Cellular Metabolic Process Biosynthetic Process Neuron Differentiation Positive Regulation Of Histone Modification Cellular Response To Nutrient Levels Response To Starvation Nervous System Development White Fat Cell Differentiation Chromatin Organization Neuron Development Negative Regulation Of Protein Localization To Plasma Membrane RNA Splicing Regulation Of Chromosome Organization Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of T Cell Receptor Signaling Pathway
Tagcloud ?		aberrations acly biphasic cascade chemoprevention citrate desaturase disturbed fatty harboring hbv hcc hepatocytes lipid livers lyase metabolism mtor pre remarkably srebf1 starting sterol subsided synchronized transgenic tumorigenesis upregulate	ataxia ataxin autism candidates continuously counterparts discovery encoded enriched hematologic hematopoietic heretofore hsc hscs interactomes modules networks null observing offering progeny quickly quiescence quiescent regenerated replenish representation similarity unappreciated
Tagcloud (Difference) ?		aberrations acly biphasic cascade chemoprevention citrate desaturase disturbed fatty harboring hbv hcc hepatocytes lipid livers lyase metabolism mtor pre remarkably srebf1 starting sterol subsided synchronized transgenic tumorigenesis upregulate	ataxia ataxin autism candidates continuously counterparts discovery encoded enriched hematologic hematopoietic heretofore hsc hscs interactomes modules networks null observing offering progeny quickly quiescence quiescent regenerated replenish representation similarity unappreciated
Tagcloud (Intersection) ?